물싸리 메탄올추출물의 피부 주름 형성 및 색소 침착 저해 효능
Anti-wrinkle and Hypopigmentation Efficacies of Potentilla fruticosa Methanol Extract
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초록
The purpose of the current study was to investigate the anti-wrinkle and hypopigmentation efficacies of Potentilla fruticosa methanol extract (PFME) in a cell-free system. Results showed that the total polyphenol and flavonoid contents of PFME were 279.31 and 183.21 mg/g, respectively. The SC50 (50% scavenging concentration) of free radical for PFME and ascorbic acid were 12.1 and 2.8 μg/mL, respectively. The IC50 (50% inhibitory concentration) of collagenase activity for PFME and ascorbic acid were 60.1 and 123.8 μg/mL, respectively. The IC50 of elastase activity for PFME and ascorbic acid were 109.1 and over 1,000 μg/mL, respectively. The IC50 of mushroom tyrosinase activity for PFME and arbutin were 138.9 and 164.3 μg/mL, respectively. These results indicate that the PFME has high antioxidant capacity and excellent anti-wrinkle and hypopigmentation efficacies in a cell-free system, and are even superior to ascorbic acid or arbutin.
Abstract
The purpose of the current study was to investigate the anti-wrinkle and hypopigmentation efficacies of Potentilla fruticosa methanol extract (PFME) in a cell-free system. Results showed that the total polyphenol and flavonoid contents of PFME were 279.31 and 183.21 mg/g, respectively. The SC50 (50% scavenging concentration) of free radical for PFME and ascorbic acid were 12.1 and 2.8 μg/mL, respectively. The IC50 (50% inhibitory concentration) of collagenase activity for PFME and ascorbic acid were 60.1 and 123.8 μg/mL, respectively. The IC50 of elastase activity for PFME and ascorbic acid were 109.1 and over 1,000 μg/mL, respectively. The IC50 of mushroom tyrosinase activity for PFME and arbutin were 138.9 and 164.3 μg/mL, respectively. These results indicate that the PFME has high antioxidant capacity and excellent anti-wrinkle and hypopigmentation efficacies in a cell-free system, and are even superior to ascorbic acid or arbutin.
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