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Cell-free 방법에서 계요등 메탄올추출물의 주름 생성 및 과색소 침착 저해 효능

Inhibitory Efficacy of Paederia scandens Methanol Extract against Wrinkle Formation and Hyperpigmentation in a Cell-free System

김영철|전근영
대한미용학회 (The Korean Society for Investigative Cosmetology)|2022.03|대한미용학회지 (Journal of Investigative Cosmetology)|제18권 제1호|pp. 1-7|DOI 10.15810/jic.2022.18.1.001

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키워드

TyrosinaseElastaseCollagenaseAntioxidant capacityPaederia scandens

초록

The purpose of this study was to examine the inhibitory efficacy of Paederia scandens methanol extract (PSME) against wrinkle formation and hyperpigmentation in a cell-free system. The total polyphenol and flavonoid contents of PSME were 373.3 TAE (tannic acid equivalent) mg/g and 305.8 RE (rutin equivalent) mg/g, respectively. At a concentration of 1,000 μg/mL, the electron-donating ability of PSME was 91.5% with an SC50 (50% scavenging concentration for free radical) of 149.2 μg/mL. The IC50 (50% inhibitory concentration) of collagenase activity for PSME and ascorbic acid were 697.9 μg/mL and 448.3 μg/mL, respectively. The IC50 of elastase activity for PSME and ascorbic acid were 824.8 μg/mL and over 1,000 μg/mL, respectively. The IC50 of mushroom tyrosinase activity for PSME and arbutin were 126.3 μg/mL and 175.3 μg/mL, respectively. According to these results, PSME has high antioxidant capacity and high anti-wrinkle and hypopigmentation efficacies in a cell-free system.

Abstract

The purpose of this study was to examine the inhibitory efficacy of Paederia scandens methanol extract (PSME) against wrinkle formation and hyperpigmentation in a cell-free system. The total polyphenol and flavonoid contents of PSME were 373.3 TAE (tannic acid equivalent) mg/g and 305.8 RE (rutin equivalent) mg/g, respectively. At a concentration of 1,000 μg/mL, the electron-donating ability of PSME was 91.5% with an SC50 (50% scavenging concentration for free radical) of 149.2 μg/mL. The IC50 (50% inhibitory concentration) of collagenase activity for PSME and ascorbic acid were 697.9 μg/mL and 448.3 μg/mL, respectively. The IC50 of elastase activity for PSME and ascorbic acid were 824.8 μg/mL and over 1,000 μg/mL, respectively. The IC50 of mushroom tyrosinase activity for PSME and arbutin were 126.3 μg/mL and 175.3 μg/mL, respectively. According to these results, PSME has high antioxidant capacity and high anti-wrinkle and hypopigmentation efficacies in a cell-free system.

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