In Vitro에서 사데풀 메탄올추출물의 피부노화 개선 효능
Improvement Efficacy of Sonchus brachyotus Methanol Extract on Skin Aging in Vitro
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초록
The aim of the current study was to investigate the improvement efficacy of Sonchus brachyotus methanol extract (SBME) on skin aging in a cell-free system. The total polyphenol and flavonoid contents of SBME were 350.6 TAE (tannic acid equivalent) mg/g and 242.0 RE (rutin equivalent) mg/g, respectively. At a concentration of 1,000 μg/mL, SBME had an electron-donating ability of 87.2% with SC50 (50% scavenging concentration for free radical) of 293.9 μg/mL. The IC50 (50% inhibitory concentration) values of collagenase and elastase activities for SBME were 351.3 μg/mL and 531.0 μg/mL, respectively, which were superior to those of ascorbic acid, the positive control (360.3 μg/ mL and over 1,000 μg/mL, respectively). The IC50 of mushroom tyrosinase activity for SBME was 608.1 μg/mL, which was inferior to arbutin (240.0 μg/mL). These results are an indication of the high antioxidant capacity and high anti-skin aging efficacies of SBME, which are superior to ascorbic acid in anti-wrinkle efficacy and inferior to arbutin in hypopigmentation efficacy.
Abstract
The aim of the current study was to investigate the improvement efficacy of Sonchus brachyotus methanol extract (SBME) on skin aging in a cell-free system. The total polyphenol and flavonoid contents of SBME were 350.6 TAE (tannic acid equivalent) mg/g and 242.0 RE (rutin equivalent) mg/g, respectively. At a concentration of 1,000 μg/mL, SBME had an electron-donating ability of 87.2% with SC50 (50% scavenging concentration for free radical) of 293.9 μg/mL. The IC50 (50% inhibitory concentration) values of collagenase and elastase activities for SBME were 351.3 μg/mL and 531.0 μg/mL, respectively, which were superior to those of ascorbic acid, the positive control (360.3 μg/ mL and over 1,000 μg/mL, respectively). The IC50 of mushroom tyrosinase activity for SBME was 608.1 μg/mL, which was inferior to arbutin (240.0 μg/mL). These results are an indication of the high antioxidant capacity and high anti-skin aging efficacies of SBME, which are superior to ascorbic acid in anti-wrinkle efficacy and inferior to arbutin in hypopigmentation efficacy.
참고문헌 (43)
- Ando H, "Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion", J Invest Dermatol, 132, pp.1222~1229 (2012)
- Azwanida ZNN, "Antioxidant, anti-collagenase, anti-elastase and anti-tyrosinase activities of an aqueous Cosmos caudatus Kunth(Asteraceae)leaf extract", Trop J Nat Prod Res, 4, pp.1124~1130 (2020)
- Cambie RC, "Potential functional foods in the traditional Maori diet", Mut Res, 523–524, pp.109~117 (2003)
- Canadanovic-Brunet JM, "Free-radical scavenging activity of wormwood(Artemisia absinthium L)extracts", J Sci Food Agr, 85, pp.265~272 (2005)
- 최선영, "식용 및 약용자원의 에스트로젠 활성과 항산화능 평가", 한국식품과학회지, 37(4), pp.549~556 (2005), 한국식품과학회
- Davies R, "The catalysis of the N-nitrosation of secondary amines by nitrosophenols", Food Chem, 6, pp.115~122 (1980)
- Draelos ZD, "Skin lightening preparations and the hydroquinone controversy", Dermatol Ther, 20, pp.308~313 (2007)
- Fisher GJ, "Mechanisms of photoaging and chronological skin aging", Arch Dermatol, 138, pp.1462~1470 (2002)
- Fisher GJ, "Pathophysiology of premature skin aging induced by ultraviolet light", N Engl J Med, 337, pp.1419~1429 (1997)
- Folin O, "On phosphotungstic-phosphomolybdic compounds as color reagents", J Biol Chem, 12, pp.239~243 (1912)
- Gilchrest BA, "DNA photodamage stimulates melanogenesis and other photoprotective responses", J Investig Dermatol Symp Proc, 4, pp.35~40 (1999)
- 하태광, "浙貝母 에탄올 추출물의 멜라닌 생성 억제 효과", 동의생리병리학회지, 25(3), pp.510~515 (2011), 한의병리학회
- 정현진, "약용식물의 추출방법에 따른 항산화 및 항당뇨 활성", 한국식품과학회지, 42(5), pp.571~577 (2010), 한국식품과학회
- Jimoh FO, "Comparison of the nutritive value, antioxidant and antibacterial activities of Sonchus asper and Sonchus oleraceus", Rec Nat Prod, 5, pp.29~42 (2011)
- Jung SW, "Screening of tyrosinase inhibitor from plants", Korean J Food Sci Technol, 27, pp.891~896 (1995)
- 강대연, "노박덩굴 추출물의 항산화 및 항균 효과", 생명과학회지, 19(1), pp.52~57 (2009), 한국생명과학회
- Eunji Kim, "The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng", Journal of Ginseng Research, 42(2), pp.218~224 (2018), 고려인삼학회[DOI]
- 김은주, "Skin Aging and Photoaging Alter Fatty Acids Composition, Including 11,14,17-eicosatrienoic Acid, in the Epidermis of Human Skin", Journal of Korean Medical Science, 25(6), pp.980~983 (2010), 대한의학회
- 김유근, "재조합 대장균 유래 베타카로틴이 함유된 기능성 화장품 제조 및 이의 임상실험을 통한 주름개선 효능 평가", 한국미생물·생명공학회지, 37(4), pp.399~404 (2009), 한국미생물·생명공학회
- Kligman D, "Cosmeceuticals", Dermatol Clin, 18, pp.609~615 (2000)
- Lanigan RS, "Final report on the safety assessment of BHT", Int J Toxicol, 21, pp.19~94 (2002)
- 이찬, "UVB로 손상이 유도된 피부세포에 해양소재 추출물의 항노화 효능", 대한화장품학회지, 38(3), pp.255~262 (2012), 사단법인 대한화장품학회
- 이진하, "산나물류의 식품 화학적 성분과 전자 공여능", 한국약용작물학회지, 19(2), pp.111~116 (2011), 한국약용작물학회
- 이정민, "Antioxidant and Anti-inflammatory Activity of Six Halophytes in Korea", Natural Product Sciences, 24(1), pp.40~46 (2018), 한국생약학회
- 임애경, "포공영의 열수 및 에탄올 추출물의 기능적 생리활성", 한국식품영양과학회지, 37(10), pp.1231~1237 (2008), 한국식품영양과학회
- Lim JT, "Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid", Dermatol Surg, 25, pp.282~284 (1999)
- 임수빈, "참죽나무 열매의 항산화 및 Elastase, Collagenase, Hyaluronidase, α-Glucosidase 저해 효과", 한국식품영양과학회지, 47(11), pp.1085~1092 (2018), 한국식품영양과학회
- Manach C, "Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies", Am J Clin Nutr, 81, pp.230S~242S (2005)
- Omaye ST, "Effect of butylated hydroxytolune and other antioxidants on mouse lung metabolism", J Toxicol Environ Health, 3, pp.829~836 (1977)
- Ortonne JP, "Melanin pigmentary disorders: treatment update", Dermatol Clin, 23, pp.209~226 (2005)
- 박은예, "대석조생, 퍼플킨, 포모사 자두품종 과피 열수추출물의 피부미백 효능", 대한미용학회지, 9(1), pp.27~32 (2013), 대한미용학회[DOI]
- Park SS, "Antioxidant activities of extracts from fruiting bodies of mushrooms", Kor J Mycol, 26, pp.69~77 (1998)
- Pérez GRM, "Antioxidant and free radical scavenging activities of 5,7,3’-trihydroxy-3,6,4’-trimethoxyflavone from Brickellia veronicaefolia", Phytother Res, 18, pp.428~430 (2004)
- Rice-Evans CA, "Antioxidant properties of phenolic compounds", Trends Plant Sci, 2, pp.152~159 (1997)
- Schiaffino MV, "Signaling pathways in melanosome biogenesis and pathology", Int J Biochem Cell Biol, 42, pp.1094~1104 (2010)
- Seiberg M, "Keratinocyte-melanocyte interactions during melanosome transfer", Pigment Cell Res, 14, pp.236~242 (2001)
- Seo SY, "Mushroom tyrosinase: recent prospects", J Agric Food Chem, 51, pp.2837~2853 (2003)
- 심성민, "청하향초(Tagetes minuta) 꽃과 줄기 추출물의 미백, 항주름 효과 및 항산화 활성", 대한미용학회지, 10(3), pp.181~189 (2014), 대한미용학회[DOI]
- Tsuji N, "The role of elastases secreted by fibroblasts in wrinkle formation: implication through selective inhibition of elastase activity", Photochem Photobiol, 74, pp.283~290 (2001)
- Vilela FC, "Anxiolytic-like effect of Sonchus oleraceus L. in mice", J Ethnopharmacol, 124, pp.325~327 (2009)
- 왕명현, "큰방가지똥 추출물의 항당뇨 및 항고혈압효과", 생약학회지, 42(1), pp.61~67 (2011), 한국생약학회
- 유희근, "Lithospermum erythrorhizon Extract Protects Keratinocytes and Fibroblasts Against Oxidative Stress", Journal of Medicinal Food, 17(11), pp.1189~1196 (2014), 한국식품영양과학회[DOI]
- 유학인, "HaCaT 세포에서 회향 열매의 피부장벽기능과 hyaluronic acid 생성에 미치는 영향", 생명과학회지, 25(8), pp.880~888 (2015), 한국생명과학회
