Aging of hair follicle stem cells and their niches
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Hair follicles in the skin undergo cyclic rounds of regeneration,degeneration, and rest throughout life. Stem cells residing inhair follicles play a pivotal role in maintaining tissue homeostasisand hair growth cycles. Research on hair follicle agingand age-related hair loss has demonstrated that a decline inhair follicle stem cell (HFSC) activity with aging can decreasethe regeneration capacity of hair follicles. This review summarizesour understanding of how age-associated HFSC intrinsic andextrinsic mechanisms can induce HFSC aging and hair loss. Inaddition, we discuss approaches developed to attenuate ageassociatedchanges in HFSCs and their niches, thereby promotinghair regrowth.
Abstract
Hair follicles in the skin undergo cyclic rounds of regeneration,degeneration, and rest throughout life. Stem cells residing inhair follicles play a pivotal role in maintaining tissue homeostasisand hair growth cycles. Research on hair follicle agingand age-related hair loss has demonstrated that a decline inhair follicle stem cell (HFSC) activity with aging can decreasethe regeneration capacity of hair follicles. This review summarizesour understanding of how age-associated HFSC intrinsic andextrinsic mechanisms can induce HFSC aging and hair loss. Inaddition, we discuss approaches developed to attenuate ageassociatedchanges in HFSCs and their niches, thereby promotinghair regrowth.
참고문헌 (102)
- Rando TA, "Stem cells, ageing and the quest for immortality", Nature, 441, pp.1080~1086 (2006)
- Van Der Flier LG, "Stem cells, self-renewal, and differentiation in the intestinal epithelium", Annu Rev Physiol, 71, pp.241~260 (2009)
- Temple S, "The development of neural stem cells", Nature, 414, pp.112~117 (2001)
- Collins CA, "Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche", Cell, 122, pp.289~301 (2005)
- Pittenger MF, "Multilineage potential of adult human mesenchymal stem cells", Science, 284, pp.143~147 (1999)
- Weissman IL, "Stem cells : units of development, units of regeneration, and units in evolution", Cell, 100, pp.157~168 (2000)
- Gronthos S, "Postnatal human dental pulp stem cells(DPSCs)in vitro and in vivo", Proc Natl Acad Sci U S A, 97, pp.13625~13630 (2000)
- Fuchs E, "Skin stem cells : rising to the surface", J Cell Biol, 180, pp.273~284 (2008)
- Blanpain C, "Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche", Cell, 118, pp.635~648 (2004)
- Inomata K, "Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation", Cell, 137, pp.1088~1099 (2009)
- Scadden DT, "Nice neighborhood : emerging concepts of the stem cell niche", Cell, 157, pp.41~50 (2014)
- Scadden DT, "The stem-cell niche as an entity of action", Nature, 441, pp.1075~1079 (2006)
- Schofield R, "The relationship between the spleen colony-forming cell and the haemopoietic stem cell", Blood Cells, 4, pp.7~25 (1978)
- Kiger AA, "Somatic support cells restrict germline stem cell self-renewal and promote differentiation", Nature, 407, pp.750~754 (2000)
- Zhang J, "Identification of the haematopoietic stem cell niche and control of the niche size", Nature, 425, pp.836~841 (2003)
- Tavazoie M, "A specialized vascular niche for adult neural stem cells", Cell Stem Cell, 3, pp.279~288 (2008)
- Shin J, "Single-cell RNA-seq with waterfall reveals molecular cascades underlying adult neurogenesis", Cell Stem Cell, 17, pp.360~372 (2015)
- Rayagiri SS, "Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal", Nat Commun, 9, pp.1075~ (2018)
- Lane SW, "Modulating the stem cell niche for tissue regeneration", Nat Biotechnol, 32, pp.795~803 (2014)
- Fuchs E, "Tissue stem cells : architects of their niches", Cell Stem Cell, 27, pp.532~556 (2020)
- Mohyeldin A, "Oxygen in stem cell biology : a critical component of the stem cell niche", Cell Stem Cell, 7, pp.150~161 (2010)
- Li L, "Stem cell niche : structure and function", Annu Rev Cell Dev Biol, 21, pp.605~631 (2005)
- Moore KA, "Stem cells and their niches", Science, 311, pp.1880~1885 (2006)
- Martin K, "Altered stem cell regeneration in irradiated intestinal crypts of senescent mice", J Cell Sci, 111, pp.2297~2303 (1998)
- Nalapareddy K, "Canonical wnt signaling ameliorates aging of intestinal stem cells", Cell Rep, 18, pp.2608~2621 (2017)
- Conboy IM, "Notch-mediated restoration of regenerative potential to aged muscle", Science, 302, pp.1575~1577 (2003)
- Brack AS, "Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis", Science, 317, pp.807~810 (2007)
- Nishimura EK, "Melanocyte stem cells : a melanocyte reservoir in hair follicles for hair and skin pigmentation", Pigment Cell Melanoma Res, 24, pp.401~410 (2011)
- Matsumura H, "Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis", Science, 351, pp.aad4395~ (2016)
- Keyes BE, "Nfatc1 orchestrates aging in hair follicle stem cells", Proc Natl Acad Sci U S A, 110, pp.E4950~4959 (2013)
- Trueb RM, "Pharmacologic interventions in aging hair", Clin Interv Aging, 1, pp.121~129 (2006)
- Nishimura EK, "Mechanisms of hair graying : incomplete melanocyte stem cell maintenance in the niche", Science, 307, pp.720~724 (2005)
- Müller-Röver S, "A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages", J Invest Dermatol, 117, pp.3~15 (2001)
- Joost S, "The molecular anatomy of mouse skin during hair growth and rest", Cell Stem Cell, 26, pp.441~457 (2020)
- Cotsarelis G, "Labelretaining cells reside in the bulge area of pilosebaceous unit : implications for follicular stem cells, hair cycle, and skin carcinogenesis", Cell, 61, pp.1329~1337 (1990)
- Tumbar T, "Defining the epithelial stem cell niche in skin", Science, 303, pp.359~363 (2004)
- Greco V, "A two-step mechanism for stem cell activation during hair regeneration", Cell Stem Cell, 4, pp.155~169 (2009)
- Morris RJ, "Capturing and profiling adult hair follicle stem cells", Nat Biotechnol, 22, pp.411~417 (2004)
- Liu Y, "Keratin 15promoter targets putative epithelial stem cells in the hair follicle bulge", J Invest Dermatol, 121, pp.963~968 (2003)
- Jaks V, "Lgr5 marks cycling, yet long-lived, hair follicle stem cells", Nat Genet, 40, pp.1291~1299 (2008)
- Vidal VP, "Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment", Current Biology, 15, pp.1340~1351 (2005)
- Rhee H, "Lhx2 maintains stem cell character in hair follicles", Science, 312, pp.1946~1949 (2006)
- Shirokova V, "Foxi3 deficiency compromises hair follicle stem cell specification and activation", Stem Cells, 34, pp.1896~1908 (2016)
- Horsley V, "NFATc1 balances quiescence and proliferation of skin stem cells", Cell, 132, pp.299~310 (2008)
- Morris RJ, "Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34", J Invest Dermatol, 120, pp.501~511 (2003)
- Hsu Y-C, "Transit-amplifying cells orchestrate stem cell activity and tissue regeneration", Cell, 157, pp.935~949 (2014)
- Wilson C, "Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen : heterogeneity and functional differences of various hair cycles", Differentiation, 55, pp.127~136 (1994)
- Rabbani P, "Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration", Cell, 145, pp.941~955 (2011)
- Tanimura S, "Hair follicle stem cells provide a functional niche for melanocyte stem cells", Cell Stem Cell, 8, pp.177~187 (2011)
- Nishimura EK, "Dominant role of the niche in melanocyte stem-cell fate determination", Nature, 416, pp.854~860 (2002)
- Jahoda CA, "Induction of hair growth by implantation of cultured dermal papilla cells", Nature, 311, pp.560~562 (1984)
- Rompolas P, "Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration", Nature, 487, pp.496~499 (2012)
- Paus R, "Mast cell involvement in murine hair growth", Dev Biol, 163, pp.230~240 (1994)
- Castellana D, "Macrophages contribute to the cyclic activation of adult hair follicle stem cells", PLoS Biol, 12, pp.e1002002~ (2014)
- Ali N, "Regulatory T cells in skin facilitate epithelial stem cell differentiation", Cell, 169, pp.1119~1129 (2017)
- Wang ECE, "A subset of TREM2(+)dermal macrophages secretes oncostatin M to maintain hair follicle stem cell quiescence and inhibit hair growth", Cell Stem Cell, 24, pp.654~669 (2019)
- Hsu YC, "Dynamics between stem cells, niche, and progeny in the hair follicle", Cell, 144, pp.92~105 (2011)
- Li KN, "Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis", Elife, 8, pp.e45977~ (2019)
- Gur-Cohen S, "Stem celldriven lymphatic remodeling coordinates tissue regeneration", Science, 366, pp.1218~1225 (2019)
- Pena-Jimenez D, "Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo", EMBO J, 38, pp.e101688~ (2019)
- Plikus MV, "Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration", Nature, 451, pp.340~344 (2008)
- Festa E, "Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling", Cell, 146, pp.761~771 (2011)
- Shook B, "The role of adipocytes in tissue regeneration and stem cell niches", Annu Rev Cell Dev Biol, 32, pp.609~631 (2016)
- Fujiwara H, "The basement membrane of hair follicle stem cells is a muscle cell niche", Cell, 144, pp.577~589 (2011)
- Shwartz Y, "Cell types promoting goosebumps form a niche to regulate hair follicle stem cells", Cell, 182, pp.578~593 (2020)
- Chen CL, "Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration", J Biomed Sci, 27, pp.43~ (2020)
- Chen C-C, "The modulatable stem cell niche : tissue interactions during hair and feather follicle regeneration", J Mol Biol, 428, pp.1423~1440 (2016)
- Choi S, "Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence", Nature, 592, pp.428~432 (2021)
- Ge Y, "The aging skin microenvironment dictates stem cell behavior", Proc Natl Acad Sci U S A, 117, pp.5339~5350 (2020)
- Giangreco A, "Epidermal stem cells are retained in vivo throughout skin aging", Aging Cell, 7, pp.250~259 (2008)
- Xie Y, "Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-alpha axis", Cell Stem Cell, 29, pp.70~85 (2022)
- Geiger H, "The aging of lympho-hematopoietic stem cells", Nat Immunol, 3, pp.329~333 (2002)
- Sudo K, "Age-associated characteristics of murine hematopoietic stem cells", J Exp Med, 192, pp.1273~1280 (2000)
- Schultz MB, "When stem cells grow old : phenotypes and mechanisms of stem cell aging", Development, 143, pp.3~14 (2016)
- Liu L, "Manifestations and mechanisms of stem cell aging", J Cell Biol, 193, pp.257~266 (2011)
- Kobielak K, "Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling", Proc Natl Acad Sci U S A, 104, pp.10063~10068 (2007)
- Lien W-H, "In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators", Nat Cell Biol, 16, pp.179~190 (2014)
- Daszczuk P, "An intrinsic oscillation of gene networks inside hair follicle stem cells : an additional layer that can modulate hair stem cell activities", Front Cell Dev Biol, 8, pp.595178~ (2020)
- Kandyba E, "Competitive balance of intrabulge BMP", Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation, 2013, pp.110, 1351~1356
- Veeman MT, "A second canon : functions and mechanisms of β-catenin-independent Wnt signaling", Dev Cell, 5, pp.367~377 (2003)
- Tiwari RL, "A Wnt5a-Cdc42axis controls aging and rejuvenation of hair-follicle stem cells", Aging(Albany NY), 13, pp.4778~ (2021)
- Wang L, "Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes", Proc Natl Acad Sci U S A, 104, pp.1248~1253 (2007)
- Zhang Z, "Wnt", β-catenin signaling promotes aging-associated hair graying in mice, 2017, pp.8, 69316~
- Crabtree GR, "NFAT signaling : choreographing the social lives of cells", Cell, 109, pp.67~79 (2002)
- Wang L, "Foxc1 reinforces quiescence in self-renewing hair follicle stem cells", Science, 351, pp.613~617 (2016)
- Lay K, "FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential", Proc Natl Acad Sci U S A, 113, pp.1506~1515 (2016)
- Li G, "SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice", EMBO J, 39, pp.e104365~ (2020)
- Cao W, "Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment", Cell Cycle, 15, pp.1093~1098 (2016)
- Chen CC, "Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4", J Invest Dermatol, 134, pp.2086~2096 (2014)
- Ji J, "Aging in hair follicle stem cells and niche microenvironment", J Dermatol, 44, pp.1097~1104 (2017)
- Koester J, "Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility", Nat Cell Biol, 23, pp.771~781 (2021)
- Lei M, "Stem cells. Aging, alopecia, and stem cells", Science, 351, pp.559~560 (2016)
- Doles J, "Age-associated inflammation inhibits epidermal stem cell function", Genes Dev, 26, pp.2144~2153 (2012)
- Chen J, "Emerging role of dermal white adipose tissue in modulating hair follicle development during aging", Front Cell Dev Biol, 9, pp.728188~ (2021)
- Jin H, "Photobiomodulation therapy for hair regeneration : A synergetic activation of beta-CATENIN in hair follicle stem cells by ROS and paracrine WNTs", Stem Cell Reports, 16, pp.1568~1583 (2021)
- Hu XM, "A systematic summary of survival and death signalling during the life of hair follicle stem cells", Stem Cell Res Ther, 12, pp.453~ (2021)
- Neves J, "Rejuvenating strategies for stem cell-based therapies in aging", Cell Stem Cell, 20, pp.161~175 (2017)
- Narbonne P, "The effect of age on stem cell function and utility for therapy", Cell Med, 10, pp.2155179018773756~ (2018)
- Harel S, "Pharmacologic inhibition of JAK-STAT signaling promotes hair growth", Sci Adv, 1, pp.e1500973~ (2015)
- Cervelli V, "The effect of autologous activated platelet rich plasma(AA-PRP)injection on pattern hair loss : clinical and histomorphometric evaluation", Biomed Res Int, 2014, pp.760709~ (2014)
- 손명진, "A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming", Experimental and Molecular Medicine, 50, pp.1~15 (2018), 생화학분자생물학회
- Wu HC, "Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice", Biomed Pharmacother, 130, pp.110520~ (2020)
