Current status and prospects of organoid-based regenerative medicine
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Organoids derived from stem cells or organ-specific progenitorsare self-organizable, self-renewable, and multicellular threedimensional(3D) structures that can mimic the function andstructure of the derived tissue. Due to such characteristics, organoidsare attracting attention as an excellent ex vivo modelfor drug screening at the stage of drug development. In addition,since the applicability of organoids as therapeutics for tissueregeneration has been embossed, the development of variousorganoids-based regenerative medicine has been rapidly progressing,reaching the clinical trial stage. In this review, we givea general overview of organoids and describe current statusand prospects of organoid-based regenerative medicine, focusingon organoid-based regenerative therapeutics currently under developmentincluding clinical trials.
Abstract
Organoids derived from stem cells or organ-specific progenitorsare self-organizable, self-renewable, and multicellular threedimensional(3D) structures that can mimic the function andstructure of the derived tissue. Due to such characteristics, organoidsare attracting attention as an excellent ex vivo modelfor drug screening at the stage of drug development. In addition,since the applicability of organoids as therapeutics for tissueregeneration has been embossed, the development of variousorganoids-based regenerative medicine has been rapidly progressing,reaching the clinical trial stage. In this review, we givea general overview of organoids and describe current statusand prospects of organoid-based regenerative medicine, focusingon organoid-based regenerative therapeutics currently under developmentincluding clinical trials.
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