Wnt Signaling in Hair Follicle Development
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Hair follicle (HF) is a miniature organ composed of epithelial and mesenchymal (dermal) compartments, and has a pivotal role in hair development and growth. In embryonic, the formation of HF is mainly regulated by mesenchymal-epithelial interactions within the dermal papilla (DP) niche, and this interaction is also responsible for the postnatal hair growth cycle and regeneration. DP cells are the main components of the mesenchymal compartments in hair bulb, and have an instruction role by generating several signals to regulate the behavior of neighbor epithelial cells in hair cycle. Among the many signaling pathways implicated in HF development and growth, Wnt/β-catenin signaling in DP cells plays critical roles in the reciprocal instructive communication between DP and epithelial cells. It is clear that Wnt/β-catenin signaling pathway is important for HF morphogenesis and regeneration. The goal of this review is to summarize our current knowledge of Wnt signaling pathway in HF development and cycling.
Abstract
Hair follicle (HF) is a miniature organ composed of epithelial and mesenchymal (dermal) compartments, and has a pivotal role in hair development and growth. In embryonic, the formation of HF is mainly regulated by mesenchymal-epithelial interactions within the dermal papilla (DP) niche, and this interaction is also responsible for the postnatal hair growth cycle and regeneration. DP cells are the main components of the mesenchymal compartments in hair bulb, and have an instruction role by generating several signals to regulate the behavior of neighbor epithelial cells in hair cycle. Among the many signaling pathways implicated in HF development and growth, Wnt/β-catenin signaling in DP cells plays critical roles in the reciprocal instructive communication between DP and epithelial cells. It is clear that Wnt/β-catenin signaling pathway is important for HF morphogenesis and regeneration. The goal of this review is to summarize our current knowledge of Wnt signaling pathway in HF development and cycling.
참고문헌 (17)
- Alonso L, "Stem cells in the skin : waste not, Wnt not", Genes & Development, 17, pp.1189~1200 (2003)
- Bejsovec A, "Wnt signaling : an embarrassment of receptors", Current Biology, 10, pp.R919~R922 (2000)
- Chen D, "Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation", Development, 139, pp.1522~1533 (2012)
- Deschene ER. Myung P, "β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche", Science, 343, pp.1353~1356 (2014)
- Hsu YC, "Dynamics between stem cells, niche, and progeny in the hair follicle", Cell, 144, pp.92~105 (2011)
- Huelsken J, "β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin", Cell, 105, pp.533~545 (2001)
- Lim X, "Wnt signaling in skin development, homeostasis, and disease", Cold Spring Harbor Perspectives in Biology, 5, pp.a008029~ (2013)
- MacDonald BT, "Wnt", beta-catenin signaling : components, mechanisms, and diseases, 2009, pp.17, 9~26
- Merrill BJ, "Wnt pathway regulation of embryonic stem cell selfrenewal", Cold Spring Harbor Perspectives in Biology, 4, pp.a007971~ (2012)
- Plikus MV, "Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration", Nature, 451, pp.340~344 (2008)
- Rompolas P, "Stem cell dynamics in the hair follicle niche", Seminars in Cell & Developmental Biology, 25-26, pp.34~42 (2014)
- Schmidt-Ullrich R, "Molecular principles of hair follicle induction and morphogenesis", BioEssays, 27, pp.247~261 (2005)
- Wodarz A, "Mechanisms of Wnt signaling in development", Annual Review of Cell and Developmental Biology, 14, pp.59~88 (1998)
- Ye J, "Wnt10b promotes differentiation of mouse hair follicle melanocytes", International Journal of Medical Sciences, 10, pp.691~698 (2013)
- Zhang Y, "Reciprocal requirements for EDA", EDAR, β-catenin signaling pathways in hair follicle induction, pp.Developmental Cell, 2009[DOI]
- Zhou L, "Activation of β-catenin signaling in CD133-positive dermal papilla cells drives postnatal hair growth", PLoS ONE, 11, pp.e0160425~ (2016)
- Zhou L, "Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity", The FEBS Journal, 283, pp.2823~2835 (2016)