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Tackling range uncertainty in proton therapy: Development and evaluation of a new multi-slit prompt-gamma camera (MSPGC) system

조성구|김찬형|장세현|조재호|최세훈|정종휘|구영모|김성훈
한국원자력학회 (Korean Nuclear Society)|2023.09|Nuclear Engineering and Technology|제55권 제9호|pp. 3140-3149|DOI 10.1016/j.net.2023.05.028

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키워드

Proton therapyRange measurementRange uncertaintyMulti-slit prompt-gamma cameraRange verification
주제분류원자력공학

초록

In theory, the sharp dose falloff at the distal end of a proton beam allows for high conformal dose to the target. However, conformity has not been fully achieved in practice, primarily due to beam range uncertainty, which is approximately 4% and varies slightly across institutions. To address this issue, we developed a new range verification system prototype: a multi-slit prompt-gamma camera (MSPGC). This system features high prompt-gamma detection sensitivity, an advanced range estimation algorithm, and a precise camera positioning system. We evaluated the range measurement precision of the prototype for single spot beams with varying energies, proton quantities, and positions, as well as for spot-scanning proton beams in a simulated SSPT treatment using a phantom. Our results demonstrated high accuracy (<0.4 mm) in range measurement for the tested beam energies and positions. Measurement precision increased significantly with the number of protons, achieving 1% precision with 5  108 protons. For spot-scanning proton beams, the prototype ensured more than 5  108 protons per spot with a 7 mm or larger spot aggregation, achieving 1% range measurement precision. Based on these findings, we anticipate that the clinical application of the new prototype will reduce range uncertainty (currently approximately 4%) to 1% or less.

Abstract

In theory, the sharp dose falloff at the distal end of a proton beam allows for high conformal dose to the target. However, conformity has not been fully achieved in practice, primarily due to beam range uncertainty, which is approximately 4% and varies slightly across institutions. To address this issue, we developed a new range verification system prototype: a multi-slit prompt-gamma camera (MSPGC). This system features high prompt-gamma detection sensitivity, an advanced range estimation algorithm, and a precise camera positioning system. We evaluated the range measurement precision of the prototype for single spot beams with varying energies, proton quantities, and positions, as well as for spot-scanning proton beams in a simulated SSPT treatment using a phantom. Our results demonstrated high accuracy (<0.4 mm) in range measurement for the tested beam energies and positions. Measurement precision increased significantly with the number of protons, achieving 1% precision with 5  108 protons. For spot-scanning proton beams, the prototype ensured more than 5  108 protons per spot with a 7 mm or larger spot aggregation, achieving 1% range measurement precision. Based on these findings, we anticipate that the clinical application of the new prototype will reduce range uncertainty (currently approximately 4%) to 1% or less.

참고문헌 (41)

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New algorithm to estimate proton beam range for multi-slit prompt-gamma camera구영모, 김찬형, 정재린한국원자력학회 · Nuclear Engineering and Technology2022 · 제54권 제9호Upgrade of gamma electron vertex imaging system for high-performance range verifi cation in pencil beam scanning proton therapy구영모, 김성훈, 김찬형, 정재린, 정종휘, 조광현, 조성구한국원자력학회 · Nuclear Engineering and Technology2022 · 제54권 제3호Performance prediction of gamma electron vertex imaging (GEVI) system for interfractional range shift detection in spot scanning proton therapy구영모, 김성훈, 김찬형, 정재린, 정종휘한국원자력학회 · Nuclear Engineering and Technology2022 · 제54권 제6호Strategies to improve the range verification of stochastic origin ensembles for low-count prompt gamma imagingHuang Hsuan-Ming한국원자력학회 · Nuclear Engineering and Technology2023 · 제55권 제10호Experiment of proof-of-principle on prompt gamma-positron emission tomography (PG-PET) system for in-vivo dose distribution verification in proton therapy서희, 민철희, 유세환, 이현철, 천보위, 최현준한국원자력학회 · Nuclear Engineering and Technology2023 · 제55권 제6호A study of multi-parameter impact on beam position accuracy for scanning proton therapyLiao Sheng, Shen Junsong, Wang Ming, Xie Guoyu, Zeng Xianhu한국원자력학회 · Nuclear Engineering and Technology2026 · 제58권 제2호

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