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Endurance exercise enhances 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of 6-hydroxydopamine-induced Parkinson's rats

Endurance exercise enhances 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of6-hydroxydopamine-induced Parkinson"s rats

김홍|김창주|윤진환|신말순|서영환|이희혁|천병옥|김영표|위승두|박후성
한국운동생리학회|2007.05|운동과학 (Exercise Science)|제16권 제2호|pp. 177-185

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키워드

세로토닌지구성 운동트레드밀 달리기파키스씨병후봉선핵

초록

박후성, 위승두, 서영환, 이희혁, 윤진환, 김홍, 신말순, 천병옥, 김창주, 김영표. 지구성 운동이 파킨스씨 병 유발 흰쥐의 후봉선핵에서 세로토닌 생성과 tryptophan hydroxylase 발현에 미치는 영향. 운동과학, 제16권 제2호. 177-185, 2007. 세로토닌은 감정, 인지력, 내분비 기능, 식욕, 성행위, 운동기능, 그리고 통증 등 다양한 생리현상을 조절하는 신경전달 물질이며, tryptophan hydroxylase는 후봉선핵에서 세로토닌의 합성을 조절하는 효소이다. 세로토닌의 기능 변화는 정신질환과 관련이 있는데 파킨슨씨 병과 세로토닌의 기능장애와의 관련성에 관하여 많은 연구가 있어 왔다. 본 연구에서는 파킨슨씨 병이 유발된 흰쥐의 봉선핵에서 트레드밀 달리기가 세로토닌 생성과 그 합성효소인 tryptophan hydroxylase의 발현에 미치는 영향을 면역조직화학법으로 연구하였다. 파킨스씨 병은 흰쥐의 선조체에 6-hydroxydopamine 을 주입하여 유발시켰으며, 하루 30분씩 2주간 트레드밀 달리기를 실시하였다. 2주 후, 운동을 시키지 않은 흰쥐의 후봉선핵에서 세로토닌 생성과 tryptophan hydroxylase의 발현이 감소 되었는 반면 트레드밀 달리기를 실시한 흰쥐의 후봉선핵에서는 세로토닌 생성과 tryptophan hydroxylase의 발현이 증가되었다. 본 실험의 결과 파킨스씨 병이 유발되었을 시 지구성 트레드밀 달리기는 뇌의 세로토닌 생성을 증가시켜 파킨슨씨 병의 증상을 효과적으로 호전시킬 것으로 보여 진다.

Abstract

Park, H.S., Wee, S.D., Sea, Y.H., Lee, H.H., Yoon, J.H., Kim, H., Shin, M.S., Chun, B.O., Kim, C.J., Kim, Y.P. Endurance exercise enhances 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of 6-hydroxydopamine-induced Parkinson's rats. Exercise Science, 16(2): 177-185, 2007. In addition to the loss of dopamine neurons in Parkinson's disease, there are many evidences on the dysfunction of 5-hydroxytryptamine (serotonin) system and degeneration of 5-hydroxytryptamine neurons in the dorsal raphe. In the present study, we investigated the effect of treadmill exercise on the synthesis of 5-hydroxytryptamine and on the expression of tryptophan hydroxylase in the dorsal raphe by using immunohistochemistry. The lesion of nigrostriatal dopamine pathway in rats was made by unilaterally injection of 6-hydroxydopamine into the striatum. The rats in the exercise group were made to run on the treadmill for 30 minutes once a day during 14 consecutive days after 6-hydroxydopamine injection. Two weeks after injection of 6-hydroxydopamine, 5- hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe were decreased. It indicates that 6-hydroxydopamine- induced destruction of dopamine system in the striatum impaired serotonergic neural system in the dorsal raphe. However, treadmill running increased 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of 6-hydroxydopamine- injection rats. The present study revealed that endurance exercise is effective for the symptom improvement in Parkinson's disease patients.* This work was supported by the Korea Research Foundation Grant funded by the Korea Government (MOEHRD)(KRF-2005-041-G00120).

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