지구성 운동이 중추신경 전달물질 활성에 미치는 영향
Effects of endurance exercise on expression of central neurotransmitters of rats
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지구성 운동이 중추신경 전달물질 활성에 미치는 영향. 운동과학, 제13권 제1호, 55-64 , 2004. 본 연구는 지구성 운동이 뇌의 세로토닌 작용 효소인 tryptophan hydroxylase(TPH)와 도파민 작용효소인 tyrosine hydroxylase(TH) 발현에 미치는 영향을 규명하기 위하여 Sprague-Dawley계 수컷 흰쥐를 대조군, 저강도와 중등도운동군으로 분류하였으며, 운동기간별로 1일, 3일, 7일, 14일, 그리고 28일운동군으로 분류하였다. 저강도운동은 트레드밀 경사도 0 %에서 3 m/min(5분), 5 m/min(5분), 8 m/min 속도에서 20분간 총 30분, 중등도운동은 트레드밀에서 경사도 0 %에서 8 m/min(5분), 11 m/min(5분), 20분간은 14 m/min 속도로 총 30분 달리기를 실시하였다. TPH는 집단(p<.001), 기간(p<.001)에서 유의한 차이가 나타났으며, 14일과 28일운동군에서 중등도운동이 저강도운동보다 유의하게 높게 나타났다. 저강도운동에서 28일운동군이 대조군 및 다른 운동기간 보다 유의하게 높게 나타났으며, 중등도운동에서 14일과 28일운동군이 대조군 및 다른 운동기간 보다 유의하게 높게 나타났다. TH는 집단(p<.001), 기간(p<.001)에서 유의한 차이가 나타났으며, 28일운동군에서 중등도운동이 저강도운동보다 유의하게 낮게 나타났다. 중등도운동서 28일운동군이 대조군 및 다른 운동기간 보다 유의하게 낮게 나타났다. 본 연구의 결과 증등도의 지구성 운동이 28일부터 중추신경계 전달물질인 TPH와 TH 활성에 영향을 미치므로, 중추피로와 관련한 세로토닌과 도파민계의 상호작용을 잘 조절하면 중추피로를 지연시킬 수 있을 것으로 생각된다.
Abstract
Effects of endurance exercise on expression of central neurotransmitters of rats. Exercise Science, 13(1): 55-64, 2004. The effect of endurance exercise on expression of central neurotransmitters of rats was investigated via immunohistochemistry. Male Sprague-Dawley rats were randomly divided into the control, low-intensity exercise(LE), moderate-intensity exercise(ME), and 1, 3, 7, 14, 28-days -exercise groups. The LE consisted with running at speed of 3m/min(5 min), 5m/min(5 min), then 8m/min for the last 20 min, and the ME was made with running at speed of 8m/min(5 min), 11m/min(5 min), then 14m/min for the last 20 min once a day. In the present results, tryptophan hydroxylase(TPH) expression in the ME was significantly increased compared to the LE, in the 14 and 28-days -exercise groups, in the 28-days-exercise group was than higher the control and different exercise period groups in the LE, and in the 14, 28-days-exercise groups was than higher the control and different exercise period groups in the LE.. Tyrosine hydroxylase(TH) expression of the 28-days -exercise group in the ME was significantly decreased compared to the control, different exercise period groups, and in the LE. The present results demonstrate that exercise intensity and duration is an important factor on the regulation of expression of central neurotransmitters in the brain and that the endurance exercise may prevent central fatigue by regulating TPH and TH expression.
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