개박하 추출물의 피부장벽 기능에 대한 효과
Effect of Nepeta cataria extract on the skin barrier function
0
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
본 연구에서 개박하(N. cataria)에 대한 항산화, 세포독성 및 피부장벽 보호인자 생성 여부, 관련 단백질 발현 등을 연구하여 기능성 소재로서 활용 가능성을 조사하였다. 개박하 추출물은 낮은 세포독성을 나타냈으며, 세포독성이 거의 없는 농도에서 개박하 추출물 처리 시, 산화방지 활성과 개박하 추출물 시료의 농도가 증가할수록 PPAR-α 리간드 결합활성이 증가되는 경향을 보여주었다. 개박하 추출물은 피부장벽 보호에 관련된 filaggrin의 발현을 촉진하였으며 또한, 관련단백질인 involucrin 발현을 향상시키는 것을 확인하였다. 이와 같은 결과로 미루어 볼 때 개박하 추출물은 피부장벽 개선 효과를 지닌 기능성 화장품에 천연물 재료로 활용될 수 있다고 사료된다.
Abstract
Nepeta cataria commonly known as catnip, catswort, catwort, and catmint, is native to Europe, Asia, and America, and has a history of use in traditional medicine for a variety of ailments. Although N. cataria exhibits desirable biological effects, such as anti-microbial, anti-inflammatory, and anti-tumor activities, the effect of N. cataria extract on the skin barrier function remains unknown. Thus, we herein examined the application of functional materials by testing a variety of physiological activities of N. cataria extract. N. cataria extract was found to possess a low cytotoxicity and a high DPPH radical scavenging activity, which resulted in a significant increase in the transactivation activity of PPAR response elements (PPREs) such as peroxisome proliferator-activated receptor (PPAR)-α. Finally, it was found that N. cataria extract promotes the expression of filaggrin and involucrin, which is related to skin barrier protection. These results indicate that N. cataria extract may be an effective comfound for improving the skin barrier function.
참고문헌 (11)
- 안정좌, "비쭈기 나무(Cleyera japonica) 추출물의 생리활성에 대한 연구", 한국자원식물학회지, 28(2), pp.153~157 (2015), 한국자원식물학회[DOI]
- Briganti S, "Chemical and instrumental approaches to treat hyperpigmentation", Pigm Cell Res, 16, pp.101~110 (2003)
- Del Rosso JQ, "The integration of physiologicallytargeted skin care in the management of atopic dermatitis : Focus on the use of a cleanser and moisturizer system incorporating a ceramide precursor, filaggrin degradation products, and specific"skin-barrier-friendly"excipients", J Drugs Dermatol, 12, pp.85~91 (2013)
- Fan J, "Mechanism of modualtion through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer", Oncotarget, 8, pp.31395~31405 (2017)
- Hanley K, "Activators of the nuclear hormone receptors PPAR-α and FXR accelerate the development of the fetal epidermal permeability barrier", J Clin Invest, 100, pp.705~712 (1997)
- Jensen JM, "Impaired spingomyelinase activity and epidermal differentiation in atopic dermatitis", J Invest Dermatol, 122, pp.1423~1431 (2004)
- Kersten S, "Roles of PPARs in health and disease", Nature, 405, pp.421~424 (2000)
- Kim B, "Eruca sativa and its flavonoid components, quercetin and isorhamnetin, improve skin barrier function by activation of peroxisome proliferatoractivated receptor(PPAR)-α and suppression of inflammatory cytokines", Phytother Res, 28, pp.1359~1366 (2014)
- 김현수, "오크라 추출물의 멜라닌 생성저해 및 피부장벽개선 효과", 한국식품과학회지, 50(3), pp.344~348 (2018), 한국식품과학회[DOI]
- Ranke J, "Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays", Ecotoxicol Environ Saf, 58, pp.396~404 (2004)
- Wang M, "Quantification of nepetalactones in catnip (Nepeta cataria L.) by HPLC coupled with ultraviolet and mass spectrometric detection", Phytochem Anal, 18, pp.157~160 (2007)