산마늘 뿌리줄기 물 추출물의 항염증 및 피부장벽 강화 효과
Aqueous Extract of Allium victorialis var. Platyphyllum Rhizome Improves Skin Barrier and Suppresses Inflammation
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Background: Atopic dermatitis is a chronic inflammatory skin disease caused by skin barrier dys- function. Allium victorialis var. platyphyllum (AVP) is a perennial plant considered as a vegetable and herbal medicine. This study aimed to investigate the effects of AVP on skin barrier and inflam- matory response and indicate its potential as a new cosmetic materials Methods and Results: High peformance liquid chromatography-ultraviolet analysis showed that AVP contains 0.12 ± 0.02 and 0.10 ± 0.01 ㎎/g of chlorogenic and gallic acids, respectively. AVP at 100 ㎍/㎖ was shown to increase the mRNA levels of filaggrin and involucrin, which are related to skin barrier function, by 1.50-fold and 1.43-fold, respectively. Based on a scratch assay, AVP at concentrations of 100 ㎍/㎖ and 200 ㎍/㎖ significantly increased wound closure rate and narrowed scratch area. AVP suppressed inflammation-related factors, such as cyclooxygenase 2 and nitric oxide, that were increased by lipopolysaccharide treatment. Additionally, AVP decreased the release of β-hexosaminidase which was increased by dinitrophenyl-bovine serum albumin treatment on RBL-2H3 cells. Conclusions: Therefore, AVP can be developed as a functional cosmetic material for atopy man- agement given its skin barrier protective, anti-inflammatory, and anti-pruritic effects.
Abstract
Background: Atopic dermatitis is a chronic inflammatory skin disease caused by skin barrier dys- function. Allium victorialis var. platyphyllum (AVP) is a perennial plant considered as a vegetable and herbal medicine. This study aimed to investigate the effects of AVP on skin barrier and inflam- matory response and indicate its potential as a new cosmetic materials Methods and Results: High peformance liquid chromatography-ultraviolet analysis showed that AVP contains 0.12 ± 0.02 and 0.10 ± 0.01 ㎎/g of chlorogenic and gallic acids, respectively. AVP at 100 ㎍/㎖ was shown to increase the mRNA levels of filaggrin and involucrin, which are related to skin barrier function, by 1.50-fold and 1.43-fold, respectively. Based on a scratch assay, AVP at concentrations of 100 ㎍/㎖ and 200 ㎍/㎖ significantly increased wound closure rate and narrowed scratch area. AVP suppressed inflammation-related factors, such as cyclooxygenase 2 and nitric oxide, that were increased by lipopolysaccharide treatment. Additionally, AVP decreased the release of β-hexosaminidase which was increased by dinitrophenyl-bovine serum albumin treatment on RBL-2H3 cells. Conclusions: Therefore, AVP can be developed as a functional cosmetic material for atopy man- agement given its skin barrier protective, anti-inflammatory, and anti-pruritic effects.
참고문헌 (40)
- Arai M, "Wound closure on the neonatal rat skin I. The modulation of the thickness of epidermis at the closing incisional wounds", CellBio, 2, pp.248~256 (2013)
- 반학진, "艾葉의 RBL-2H3 비만세포 탈과립, cytokine 생산 및 FcεRI 유전자 발현에 미치는 영향", 동의생리병리학회지, 26(6), pp.915~921 (2012), 한의병리학회
- Bylund S, "Prevalence and incidence of atopic dermatitis : A systematic review", Acta Dermato-Venereologica, 100, pp.320~329 (2020)
- Candi E, "The cornified envelope : a model of cell death in the skin", Nature Reviews Molecular Cell Biology, 6, pp.328~340 (2005)
- 최종원, "식이성 고지혈 및 비만에 대한 산마늘 추출물의 효과", 생약학회지, 36(2), pp.109~115 (2005), 한국생약학회
- Dang E, "Inducible nitric oxide synthase is required for epidermal permeability barrier homeostasis in mice", Experimental Dermatology, 29, pp.1027~1032 (2020)
- de Lucas R, "New cosmetic formulation for the treatment of mild to moderate infantile atopic dermatitis", Children, 6, pp.17~ (2019)
- Dębińska A, "New treatments for atopic dermatitis targeting skin barrier repair via the regulation of FLG expression", Journal of Clinical Medicine, 10, pp.2506~ (2021)
- Elias PM, "Stratum corneum defensive functions : An integrated view", Journal of Investigative Dermatology, 125, pp.183~200 (2005)
- Engebretsen KA, "Skin barrier function and allergens", Current Problems in Dermatology, 49, pp.90~102 (2016)
- Furue M, "Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2 : Pathogenic implications in atopic dermatitis", International Journal of Molecular Sciences, 21, pp.5382~ (2020)
- 홍은영, "Determination of Flavonoids from Allium victorialis var. platyphyllum and Their Effect on Gap Junctional Intercellular Communication", Food Science and Biotechnology, 16(5), pp.747~752 (2007), 한국식품과학회
- Kalinin A, "Assembly of the epidermal cornified cell envelope", Journal of Cell Science, 114, pp.3069~3070 (2001)
- Kawasaki H, "Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice", Journal of Allergy and Clinical Immunology, 129, pp.1538~1546 (2012)
- Kezic S, "Filaggrin and skin barrier function", Current Problems in Dermatology, 49, pp.1~7 (2016)
- Khan S, "A review on phytochemical constituents and pharmacological properties of Allium victorialis", International Journal of Scientific and Engineering Research, 10, pp.278~288 (2019)
- Khan S, "Alliumonoate : A new cyclopentane derivative from Allium victorialis", Journal of Asian Natural Products Research, 13, pp.1165~1169 (2011)
- 김현정, "아토피피부염과 피부 장벽 이상", Allergy Asthma & Respiratory Disease, 1(1), pp.20~28 (2013), 대한 소아알레르기 호흡기학회
- 김진영, "산마늘의 부위별 성분분석 및 생리활성 평가", 한국식품과학회지, 44(1), pp.100~105 (2012), 한국식품과학회
- Kitano T, "Impaired healing of a cutaneous wound in an inducible nitric oxide synthase-knockout mouse", Dermatology Research and Practice, 2017, pp.2184040~ (2017)
- Kothari D, "Allium flavonols : Health benefits, molecular targets, and bioavailability", Antioxidants, 9, pp.888~ (2020)
- Lee CW, "Urban particulate matter down-regulates filaggrin via COX2 expression", PGE2 production leading to skin barrier dysfunction, 2016, pp.6, 27995~
- Lee HJ, "The whitening cosmetics ingredients development possibility study using flavonoid of Allium victorialis var. platyphyllum’s above ground part ethanol extracts", Master, pp.2015
- 이원주, "The Expression of Involucrin, Loricrin, and Filaggrin in Cultured Sebocytes", Annals of Dermatology, 26(1), pp.134~137 (2014), 대한피부과학회
- Xue Mei Li, "Stimulation of keratinocyte differentiation by extract of combined medicinal plant", Journal of Biomedical and Translational Research, 15(4), pp.176~181 (2014), 동물의학연구소[DOI]
- Lowes MA, "Pathogenesis and therapy of psoriasis", Nature, 445, pp.866~873 (2007)
- Mathijssen RHJ, "Determining the optimal dose in the development of anticancer agents", Nature Reviews Clinical Oncology, 11, pp.272~281 (2014)
- Mu Z, "Molecular biology of atopic dermatitis", Clinical Reviews in Allergy and Immunology, 47, pp.193~218 (2014)
- Nishimura H, "Volatile flavor components and antithrombotic agents : Vinyldithiins from Allium victorialis L", Journal of Agricultural and Food Chemistry, 36, pp.563~566 (1988)
- Obedencio GP, "Involucrin-positive keratinocytes demonstrate decreased migration speed but sustained directional migration in a DC electric field", Journal of Investigative Dermatology, 113, pp.851~855 (1999)
- Santos LM, "Application and possible benefits of high hydrostatic pressure or high-pressure homogenization on beer processing : A review", Food Science and Technology International, 23, pp.561~581 (2017)
- Tiwari P, "Phytochemical screening and extraction : A review", Internationale Pharmaceutica Sciencia, 1, pp.98~106 (2011)
- Venkatakrishna K, "Acute and sub-chronic toxicity evaluation of a standardized green coffee bean extract (CGA-7™) in Wistar albino rats", SAGE Open Medicine, 9, pp.2050312120984885~ (2021)
- Wang L, "The biological activity mechanism of chlorogenic acid and its applications in food industry: A review", Frontiers in Nutrition, 9, pp.943911~ (2022)
- 우경완, "Phytochemical Constituents of Allium victorialis var. platyphyllum", Natural Product Sciences, 19(3), pp.221~226 (2013), 한국생약학회
- Xu B, "Total phenolics, phenolic acids, isoflavones, and anthocyanins and antioxidant properties of yellow and black soybeans as affected by thermal processing", Journal of Agricultural and Food Chemistry, 56, pp.7165~7175 (2008)
- Xu B, "Phytochemical profiles and health-promoting effects of cool-season food legumes as influenced by thermal processing", Journal of Agricultural and Food Chemistry, 57, pp.10718~10731 (2009)
- Yosipovitch G, "Neuroimmune interactions in chronic itch of atopic dermatitis", Journal of the European Academy of Dermatology and Venereology, 34, pp.239~250 (2020)
- Yosipovitch G, "Skin barrier damage and itch : Review of mechanisms, topical management and future directions", Acta Dermato-Venereologica, 99, pp.1201~1209 (2019)
- Zanwar AA, "Polyphenols in human health and disease", pp.1045~1047 (2014), Academic Press