페녹시에탄올과 알칸디올계 화합물의 혼합사용이 항균 활성과 화장품 방부력에 미치는 영향
Effect of Phenoxyethanol and Alkane Diol Mixture on the Antimicrobial Activity and Antiseptic Ability in Cosmetics
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초록
The preservatives traditionally used in the cosmetics such as parabens are regarded as a component to be eliminated because of their harmful properties. Nonetheless, the addition of anti-microbial agents is unavoidable to prevent the microbial contamination. Alkane diols, one of the widely used moisturizing components of cosmetics, are now used as the alternative of anti-microbial agents. In this work, alkane diols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol and phenoxyethanol were tested to determine their anti-microbial activity and the possibility to be used as the preservatives in the cosmetics. The inhibition of microbial growth with single alkane diol was not strong enough except the 1,2-octanediol, which could weakly inhibit the four tested microorganisms including E. coli, P. aeruginosa, S. aureus, C. albicans . For this reason, each alkane diol and phenoxyethanol combination is not suitable for the cosmetic preservatives. On the other hand, the combined three chemicals, 1,2-hexanediol (0.3%), 1,2-octanediol (0.3%) and phenoxyethanol (0.3%) could successfully inhibit the growth of the four microorganisms and this was confirmed by applying them to the cosmetic emulsion and showing that a 3 log reduction of microorganism was possible. On the basis of these results, the combination of alkane diols with phenoxyethanol could be used as a good alternative of cosmetic preservatives.
Abstract
The preservatives traditionally used in the cosmetics such as parabens are regarded as a component to be eliminated because of their harmful properties. Nonetheless, the addition of anti-microbial agents is unavoidable to prevent the microbial contamination. Alkane diols, one of the widely used moisturizing components of cosmetics, are now used as the alternative of anti-microbial agents. In this work, alkane diols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol and phenoxyethanol were tested to determine their anti-microbial activity and the possibility to be used as the preservatives in the cosmetics. The inhibition of microbial growth with single alkane diol was not strong enough except the 1,2-octanediol, which could weakly inhibit the four tested microorganisms including E. coli, P. aeruginosa, S. aureus, C. albicans . For this reason, each alkane diol and phenoxyethanol combination is not suitable for the cosmetic preservatives. On the other hand, the combined three chemicals, 1,2-hexanediol (0.3%), 1,2-octanediol (0.3%) and phenoxyethanol (0.3%) could successfully inhibit the growth of the four microorganisms and this was confirmed by applying them to the cosmetic emulsion and showing that a 3 log reduction of microorganism was possible. On the basis of these results, the combination of alkane diols with phenoxyethanol could be used as a good alternative of cosmetic preservatives.
참고문헌 (14)
- 柳美淑, "化粧品의 微生物 汚染防止에 대한 防腐制 效果", 석사, 화학공학, pp.1991
- 이후섭, "가스크로마토그래피를 이용한 화장품 중 항균작용의 3종의 직쇄상 1,2-알칸디올류의 동시분석", 대한화장품학회지, 40(1), pp.37~44 (2014), 대한화장품학회[DOI]
- 조춘구, "합성 항균제를 대체하기 위한 천연물질의 항균효과", 대한피부미용학회지, 28, pp.166~185 (2002)
- Orth DS, "Presevative-free and selfpreserving cosmetics and drugs", Cosmet. Toil, 113, pp.51~58 (1998)
- Kabara J, "Preservative-free and self-preserving cosmetic and drug products: Principle and practices", Cosmetic Science and Technology Series, 16, pp.243~261 (1997)
- Lee E, "The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols", Int. J Cosmetic Sci, 33, pp.421~425 (2011)
- Levy SB, "Safety of a preservative system containing 1,2 hexanediol and capryly glycol", Cutaneous and occular toxicology, 28, pp.23~24 (2009)
- Soni MG, "Safety assessment of esters of p-hydroxybenzoic acid (parabens)", Food Chem. Toxcol, 43, pp.985~1015 (2005)
- Shintre MS, "Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride", Int. J. Hyg. Environ. Health, 209, pp.477~487 (2006)
- Schmaus G, "1,2-diol combinations: A safe way to reduce preservatives in cosmetics formulation", Cosmetic and Toiletries, 123, pp.53~64 (2008)
- Shigeru Abe, "Anti-Candida albicans Activity of essential Oils Including Lemongrass Oil and its Component", Citral. Jpn J. Med. Myeol, 44, pp.119~124 (2003)
- Marouchoc SR, "Cosmetic preservation", Cosmet. Technol, 2, pp.38~ (1980)
- Levy S., "Safety of a new preservative system containing 1,2-hexanediol and 1,2-octanediol for use in cosmetic products", J. Am. Acad. Dermatol, 58, pp.55~ (2008)
- Gaonkar TA, "In vivo efficacy of an alcohol-based surgical hand disinfectant containing a synergistic combination of ethylhexylglycerin and preservatives", J. Hosp. Infect, 63, pp.412~427 (2006)