12개월간의 운동이 고령자의 림프구 아집단에 미치는 영향
Effects of 12 months of exercise training on lymphocyte subsets in the elderly humans
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이호성. 12개월간의 운동이 고령자의 림프구 아집단에 미치는 영향. 운동과학, 제15권 제3호. 173-180, 2006. 본 연구의 목적은 고령자를 대상으로 12개월간 계속적인 운동이 고령자의 림프구 아집단에 미치는 영향에 대해 검토하였다. 운동 습관이 없는 고령자 27명(남성 7명, 여성 20명)을 연구대상으로 하였으며, 대상자는 1일 트레이닝 시간 60-90분간, 주 2일(저항성/1일, 지구성/1일)의 트레이닝을 12개월간 계속해서 참가 하였다. 림프구 아집단(백혈구, 림프구, NK, T, Th, Tc, Th1, memory-Th, NKT)의 각 세포수는 트레이닝 전, 5개월 후, 그리고 12개월 후에 각각 측정하였다. 백혈구, 림프구, NK, 및 Tc세포수는 트레이닝 전, 5개월 후, 및 12개월 후에 있어서 통계적으로 유의한 차이는 나타나지 않았다. T 및 Th세포수는 트레이닝 전과 비교해서 12개월 후에 유의하게 증가하였다(p<.05, p<.01). Th1세포수는 트레이닝 전 및 트레이닝 5개월 후와 비교해서 12개월 후에 유의하게 증가하였다(p<.01). memory-Th 및 NKT세포수는 트레이닝 전과 5개월 후에, 트레이닝 5개월 후와 12개월 후에, 트레이닝 전과 12개월 후에 각각 비교하여 유의하게 증가하였다(p<.01). 이상의 결과, 12개월간 계속적인 운동은 고령자의 면역 기능을 유지 또는 향상시킬 가능성이 있다고 생각된다.
Abstract
Lee, H.S. Effects of 12 months of exercise training on lymphocyte subsets in the elderly humans. Exercise Science. 15(3): 173-180, 2006. The purpose of this study was to investigate the effects of 12 months of exercise training on lymphocyte subsets in the elderly humans. Twenty seven elderly humans (7 men, 20 women; mean (SD) age 66.1 (4.20) years) continuously participated exercise training for 60-90 minute/day, 2days/week (resistance/1day, endurance/1day), for 12 months. Lymphocyte subsets number(leukocyte, lymphocyte, NK, T, Th, Tc, Th1, memory-Th, and NKT cells) were measured before training, and at five and 12 months during the training period. leukocyte, lymphocyte, NK, and Tc cells number were not significantly different at time course during the training period. T and Th cells number were significantly increased after 12 months of training than at before training (p<.05, p<.01 respectively). Th1 cells number was significantly increased after 12 months of training (p<.01) compared with before and five months of training. Memory-Th and NKT cells number were significantly increased after both five (p<.01) and 12 months of training (p<.01) compared with before of training. Also, after 12 months of training, memory-Th and NKT cells number were significantly increased than at five months of training (p<.01). A continuous exercise training of 12 months seem to maintain or enhance immune function in elderly humans.
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