Synthesis and characterization of biphasic calcium phosphate ceramics using a sponge coating method
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초록
Biphasic calcium phosphate (BCP) bone grafts were successfully synthesized using the 45 ppi polyurethane sponge coatingmethod. XRD results revealed that the BCP scaffolds were mainly composed of hydroxyapatite and β-tricalcium phosphate(β-TCP). As the number of BCP coatings increased from 1 to 5, the pore size and the wall size decreased from 480 ± 93 μmto 306 ± 120 μm and increased from 104 ± 25 μm to 186 ± 40 μm, respectively. The BCP scaffolds coated once, twice, threetimes, four times and five times, exhibited average cell viability of 106%, 109%, 114%, 107%, and 93%. The BCP scaffoldsshowed no evidence of causing cell lysis or toxicity. In addition, the cell proliferation results suggested that L-929 cells adheredwell to the BCP scaffolds and proliferated continuously with increasing time, indicating that the BCP powders are highlyapplicable to the synthetic bone grafts.
Abstract
Biphasic calcium phosphate (BCP) bone grafts were successfully synthesized using the 45 ppi polyurethane sponge coatingmethod. XRD results revealed that the BCP scaffolds were mainly composed of hydroxyapatite and β-tricalcium phosphate(β-TCP). As the number of BCP coatings increased from 1 to 5, the pore size and the wall size decreased from 480 ± 93 μmto 306 ± 120 μm and increased from 104 ± 25 μm to 186 ± 40 μm, respectively. The BCP scaffolds coated once, twice, threetimes, four times and five times, exhibited average cell viability of 106%, 109%, 114%, 107%, and 93%. The BCP scaffoldsshowed no evidence of causing cell lysis or toxicity. In addition, the cell proliferation results suggested that L-929 cells adheredwell to the BCP scaffolds and proliferated continuously with increasing time, indicating that the BCP powders are highlyapplicable to the synthetic bone grafts.
참고문헌 (12)
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