Synthesis and thermodynamic analysis of Mg-doped calcium phosphate-based porous scaffolds
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A strategy using the sucrose evaporation technique for producing highly macroporous ceramic scaffolds with magnesium (Mg)-doped multiphasic or biphasic calcium phosphates was proposed. X-ray diffraction was performed to identify the ceramic phases, and thermogravimetric analysis and simultaneous differential scanning calorimetry (TGA/DSC) were used to analyze thermal behavior under different sintering temperatures. Product compositions with Ca/P molar ratios between 1.5 and 1.67 were synthesized and thermally treated up to 1050-1400 o C. Results showed that controlling the sintering temperature enabled various adjustable biphasic and multiphasic calcium phosphates to be prepared. Hydroxyapatite (HA) was obtained by increasing the sintering temperature of the reactants with sucrose and multiphasic á-tricalcium phosphates (TCP) and β- TCP were stabilized by the addition of MgO. The spaces occupied by the sucrose (~ 200 μm) produced non-uniform pores after sucrose vaporized. These pores had dimensions ranging from several micrometers to hundreds of micrometers in the final fabricated scaffolds with an interconnected network. Considering phase decomposition and transfer into TCP, the phase amount and grain size of HA decreased with increased sintering temperature. Calculation of the Arrhenius equation revealed that the grain size with Mg doping was relatively larger and had reduced activation energy and smaller exothermic enthalpy, indicating that the formation of β-TCP was stabilized by the MgO additive.
Abstract
A strategy using the sucrose evaporation technique for producing highly macroporous ceramic scaffolds with magnesium (Mg)-doped multiphasic or biphasic calcium phosphates was proposed. X-ray diffraction was performed to identify the ceramic phases, and thermogravimetric analysis and simultaneous differential scanning calorimetry (TGA/DSC) were used to analyze thermal behavior under different sintering temperatures. Product compositions with Ca/P molar ratios between 1.5 and 1.67 were synthesized and thermally treated up to 1050-1400 o C. Results showed that controlling the sintering temperature enabled various adjustable biphasic and multiphasic calcium phosphates to be prepared. Hydroxyapatite (HA) was obtained by increasing the sintering temperature of the reactants with sucrose and multiphasic á-tricalcium phosphates (TCP) and β- TCP were stabilized by the addition of MgO. The spaces occupied by the sucrose (~ 200 μm) produced non-uniform pores after sucrose vaporized. These pores had dimensions ranging from several micrometers to hundreds of micrometers in the final fabricated scaffolds with an interconnected network. Considering phase decomposition and transfer into TCP, the phase amount and grain size of HA decreased with increased sintering temperature. Calculation of the Arrhenius equation revealed that the grain size with Mg doping was relatively larger and had reduced activation energy and smaller exothermic enthalpy, indicating that the formation of β-TCP was stabilized by the MgO additive.
참고문헌 (32)
- Wen-Cheng Chen, "Carbon black sintering effects on the composition of multiphase calcium phosphate bioceramics", Journal of Ceramic Processing Research, 14(3), pp.279~283 (2013), 세라믹공정연구센터[DOI]
- O. Bermudez, , Biomaterials, 15, pp.1019~1023 (1994)
- D. Knaack, , J. Biomed. Mater. Res, 43, pp.399~409 (1998)
- O. Malard, , J. Biomed. Mater. Res, 46, pp.103~111 (1999)
- S. V. Dorozhkin, , J. Mater. Sci, 42, pp.1061~1095 (2007)
- W. C. Chen, , Mater. Sci. Eng. C, 33, pp.2713~2722 (2013)
- R. Z. Legeros, , Adv. Dent. Res, 2, pp.164~180 (1988)
- W. C. Chen, , Mater. Sci. Eng. C, 33, pp.1143~1151 (2013)
- K. A. Moore, , Science, 311, pp.1880~1885 (2006)
- H. Tai, , Eur. Cells Mater, 14, pp.64~77 (2007)
- A. M. Le Ray, , Ceram. Int, 36, pp.93~101 (2010)
- C. L. Ko, , J. Mech. Behav. Biomed, 14, pp.227~238 (2012)
- H.H.K. Xu, , J. Biomed. Mater. Res. A, 75A, pp.832~840 (2005)
- D. Weir, , J. Biomed. Mater. Res. A, 77A, pp.487~496 (2006)
- C.W. Chang, , Appl. Mech. Mater, 365-366, pp.983~986 (2013)
- W. E. Brown, , J. Res. Natl. Bur. Stand, 69A, pp.547~551 (1965)
- P. Scherrer, , Mathematisch-Physikalische Klasse, 2, pp.98~100 (1918)
- M. Monshi, , World J. Nano Sci. Eng, 2, pp.154~160 (2012)
- M. Jarcho, , J. Mater. Sci, 11, pp.2027~2035 (1976)
- F. H. Lin, , Mater. Sci. Eng. C, 13, pp.97~104 (2000)
- I. M. Hung, , Int. J. Mol. Sci, 13, pp.13569~13586 (2012)
- S. Kannan, , J. Am. Ceram. Soc, 89, pp.2757~2761 (2006)
- S. C. Wu, , Mater. Charact, 62, pp.526~534 (2011)
- S. H. Kwon, , J. Eur. Ceram. Soc, 23, pp.1039~1045 (2003)
- G. Muralithran, , Ceram. Int, 26, pp.221~230 (2000)
- N. Kivrak, , J. Am. Ceram. Soc, 81, pp.2245~2252 (1998)
- C. Stahli, , Acta Biomater, 6, pp.2760~2772 (2010)
- M. Mazaheri, , J. Alloys Comp, 471, pp.180~184 (2009)
- Y. S. Chang, , J. Cryst. Growth, 243, pp.319~326 (2002)
- J. C. Roldán, , Eur. Cells Mater, 14, pp.91~ (2007)
- K. Saal, , Int. J. Mater. Prod. Tech, 40, pp.2~14 (2011)
- M. Petrovic, "Self assembly of biomimetic hydroxyapatite on the surface of different polymer thin films", Journal of Ceramic Processing Research, 13(4), pp.398~404 (2012), 세라믹공정연구센터[DOI]