배롱나무 잎 추출물 및 분획물의 항염 및 주름개선 효능평가
Efficacy Evaluation of Anti-inflammatory and Wrinkle Improvement of Lagerstroemia indica Leaves Extracts and Fractions
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To confirm the potential for application of Lagerstroemia indica leaves as functional cosmetic materials, samples were prepared by extraction with 70% ethanol and fraction with ethyl acetate, methylene chloride, and hexane. The result of evaluation of the anti-inflammatory activity at a concentration without cytotoxicity showed that the ability to inhibit NO production in the crude extracts was the highest at 24.44%. The result of evaluation of the mRNA expression levels of HAS-2 and AQP-3 showed that there was no significant effect (p<0.05). According to the result of confirming the mRNA expression level of MMP-1, treatment w ith the ethyl acetate fraction at a concentration of 60 μg/mL resulted in an expression inhibitory effect of 51.54% and significance was recognized (p<0.05). The results of this study confirmed the applicability of the L. indica leaves fraction as an anti-inflammatory and anti-wrinkle cosmetic.
Abstract
To confirm the potential for application of Lagerstroemia indica leaves as functional cosmetic materials, samples were prepared by extraction with 70% ethanol and fraction with ethyl acetate, methylene chloride, and hexane. The result of evaluation of the anti-inflammatory activity at a concentration without cytotoxicity showed that the ability to inhibit NO production in the crude extracts was the highest at 24.44%. The result of evaluation of the mRNA expression levels of HAS-2 and AQP-3 showed that there was no significant effect (p<0.05). According to the result of confirming the mRNA expression level of MMP-1, treatment w ith the ethyl acetate fraction at a concentration of 60 μg/mL resulted in an expression inhibitory effect of 51.54% and significance was recognized (p<0.05). The results of this study confirmed the applicability of the L. indica leaves fraction as an anti-inflammatory and anti-wrinkle cosmetic.
참고문헌 (20)
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