실리콘 이온이 첨가된 biphasic calcium phosphate의 합성 및 특성평가

김동현; 김태완; 윤석영; 박홍채; 송창원

논문KCI 등재

실리콘 이온이 첨가된 biphasic calcium phosphate의 합성 및 특성평가

Synthesis and characterization of silicon ion substituted biphasic calcium phosphate

한국결정성장학회 (The Korea Association Of Crystal Growth, Inc.)|2010.10|한국결정성장학회지 (Journal of the Korean Crystal Growth and Crystal Technology)|제20권 제5호|pp. 243-248

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키워드

Substitution Silicon Biphasic calcium phosphate Bioactivity

주제분류재료공학

초록

Si-BCP(si-substituted biphasic calcium phosphate)를 제조하기 위하여 Ca(NO3)2·4H2O, (NH4)2HPO4, Si(OC2H5)4을출발 물질로 공침법(co-precipitation process)을 이용하여 합성하였다. 합성된 분말의 HAp/β-TCP 결정상 비율 및 Si-P 치환거동은 X-선 회절 상 분석을 이용하여 측정하였고, silicon ion 첨가 시 나타나는 BCP의 화학적 결합거동을 측정하기 위하여 FT-IR를 사용하여 분석하였다. 또한 Si-BCP 분말의 in-vitro 생분해거동 및 생체활성도를 측정하기 위하여 제조된 분말을 SBF(simulated body fluid) solution에 침적시킨 뒤 분말의 형상과 구성 성분은 SEM과 EDS를 통하여 확인하였다.

Abstract

Si-substituted biphasic calcium phosphates (Si-BCP) were prepared by co-precipitation method. X-ray diffraction and fourier transform infrared spectroscopy were used to characterize the structure of Si-BCP powders. The Si-BCP powders with various Ca/(P+Si) molar ratio were carried out on structural change of hydroxyapatite (HAp) and β-tricalcium phosphate (ß-TCP). The in-vitro bioactivity of the Si-BCP powders was determined by immersing the powders in SBF solution, after that observing the chemical composition and morphology change by X-ray diffraction, scanning electron microscope and energy dispersive spectroscopy.

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