X-선 회절분석을 이용한 biphasic calcium phosphate 분말의 화학양론적 Ca/P 비율 확인
Determination of stoichiometric Ca/P ratio in biphasic calcium phosphates using X-ray diffraction analysis
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
X-선 회절 분석방법을 통해 biphasic calcium phosphate(BCP) 분말의 Ca/P 몰 비율을 확인하고 특성을 평가하였다. 다양한 화학 양론적인 Ca/P 몰 비율을 가지는 BCP 분말은 공침반응 및 하소과정을 통해 합성하였다. 1.5에서 1.67의Ca/P 몰 비율을 가지는 분말의 조성은 초기 출발물질의 Ca/P 몰 비율, pH 10에서의 공침 과정 및 900oC 열처리에 의해 정해졌다. 화학 양론적 Ca/P 몰 비율을 가지는 BCP 분말의 구조, 형상 및 화학적 특성평가는 XRD의 상-정량 확인 분석을바탕으로 주사전자현미경 및 유도 결합 플라즈마 분광분석기와 함께 수행 하였다. BCP 분말의 용해도는 36.5oC 및 pH 7.4의 phosphate buffer solution(PBS)에서 특성평가 하였다.
Abstract
The calcium to phosphate ratio (Ca/P) in biphasic calcium phosphates powders using X-ray diffraction analysis (XRD) was characterized. The BCP powders with various stoichiometric Ca/P molar ratio were synthesized with coprecipitation process and calcination. Compositions of the powders with Ca/P molar ratio between 1.5 and 1.67 were subjected to starting Ca/P molar ratio, pH = 10, and thermal treatment up to 900oC. The structural, morphological and chemical characterizations for BCP powders with stoichiometric Ca/P ratio were carried out with scanning electron microscope (SEM) and inductively coupled plasma atomic emission spectroscopy (ICP-AES) and a phase quantification was investigated by XRD. The solubility of HAp, β-TCP, and BCP powders was tested in the phosphate buffer solution (PBS)at 36.5oC and pH = 7.4.
참고문헌 (18)
- 박광범, "미세다공성 Biphasic calcium phosphate ceramics의 골이식 대체재로서의 기본특성에 대한 비교연구", The Journal of the Korean Academy of Periodontology (JPIS), 36(4), pp.797~808 (2006), 대한치주과학회
- R.W. Bucholz, "Hydroxyapatite and tricalcium phosphate bone graft substitutes", Orthop. Clic. North Am., 18, pp.323~ (1987)
- W. Suchanek, "Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants", J. Mater. Res., 13, pp.94~ (1998)
- Y. Ota, "Bone formation following implantation of fibrous compounds (β-Ca(PO3)2, CaCO3(Aragonite)) into bone marrow", J. Mater. Sci., 12, pp.895~ (2002)
- 김종희, "합성 수산화아파타이트의 미세구조 발말", 한국세라믹학회지, 41(4), pp.4~4 (2004), 한국세라믹학회
- 백동주, "α-TCP의 가수분해에 의한 수산화아파타이트 휘스커의 제조", 한국세라믹학회지, 40(6), pp.17~17 (2003), 한국세라믹학회
- S.H. Kwon, "Synthesis and dissolution behavior of β-TCP and HA", β-TCP composite powders, 2003, pp.23, 1039~
- I. Manjubala, "In-situ synthesis of biphasic calcium phosphate ceramics using microwave irradiation", Mater. Chem. & Phys., 71, pp.272~ (2001)
- C.K. Hsu, "The preparation of biphasic porous calcium phosphate by the mixture of Ca(H2PO4)2H2O and CaCO3", Mater. Chem. & Phys., 9470, pp.1~ (2002)
- Y. Pand, "Preparation of β-TCP with high thermal stability by solid reaction route", J. Mater. Sci., 38, pp.1049~ (2003)
- N. Kivrak, "Synthesis of calcium hydroxyapatite-tri calcium phosphate (HA-TCP) composite bioceramic powders and their sintering behavior", J. Am. Ceram. Soc., 81, pp.2245~ (1998)
- S.V. Dorozhkin, "Solid-state transformation of a nonstoichiometric calcium deficient apatite into the biphasic calcium phosphate", Key Eng., 192, pp.155~195 (2001)
- M. Benahmed, "Biodegradation of synthetic biphasic calcium phosphate by human monocytes in vitro", Biomaterials, 17, pp.2173~ (1996)
- R. Xin, "A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo", Biomaterials, 26, pp.6477~ (2005)
- R.Z. LeGeros, "Apatites in biological system", Prog. Crystal Growth Charact., 4 (1981)
- R.Z. LeGeros, "Biphasic Calcium phosphate bioceramics:preparation, properties and applications", J. Mater. Sic., 14, pp.201~ (2003)
- R.Z. LeGeros, "Calcium phosphates in oral biology and medicine (Monograph in Oral Science)", Karger, 15 (1991)
- S.-H. Kwon, "Synthesis and dissolution behavior of β-TCP and HA", β-TCP composite powders, 2003, pp.23, 1039~