合歡皮 추출물의 항산화활성 및 혈관계에 미치는 영향에 대한 연구
A study on antioxidative and Antihypertensive Effects of the Water Extracts of Albizzia julibrissin
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Albizzia julibrissin have long been used for clinical therapy associated especially with menopausal symptoms in Korea. To provide a scientific rationale for such use, we have investigated the antioxidant and vasorelaxant effects of Albizzia julibrissin. Antioxidant activity was measured using the , -diphenyl- -picrylhydrazyl (DPPH) radical scavenging and superoxide anion radical scavenging methods. The water extracts of Albizzia julibrissin (AJ-Ex) produced a dose-dependent radical scavenging activity against DPPH and superoxide anion radical. The vasorelaxant effects of Albizzia julibrissin and its possible mechanism of action were investigated on the vasomotor tone of the rat thoracic aorta rings in an organ bath. The extracts produced a dose-dependent transient relaxation in the endothelium-intact rat aorta precontracted with norepinephrine (NE). This relaxant effect was significantly attenuated by removal of the endothelium and also by treatment with such nitric oxide (NO) synthase inhibitor L-NNA (10 M). Neither a prostacycline synthase inhibitor, indomethacin (10 M), nor a muscarinic receptor antagonist, atropine (10 M), altered the AJ-Ex induced endothelium-dependent relaxation. In conclusion, these antioxidant and vasorelaxant effects of the extracts may contribute to the beneficial effects in postmenopausal women.
Abstract
Albizzia julibrissin have long been used for clinical therapy associated especially with menopausal symptoms in Korea. To provide a scientific rationale for such use, we have investigated the antioxidant and vasorelaxant effects of Albizzia julibrissin. Antioxidant activity was measured using the , -diphenyl- -picrylhydrazyl (DPPH) radical scavenging and superoxide anion radical scavenging methods. The water extracts of Albizzia julibrissin (AJ-Ex) produced a dose-dependent radical scavenging activity against DPPH and superoxide anion radical. The vasorelaxant effects of Albizzia julibrissin and its possible mechanism of action were investigated on the vasomotor tone of the rat thoracic aorta rings in an organ bath. The extracts produced a dose-dependent transient relaxation in the endothelium-intact rat aorta precontracted with norepinephrine (NE). This relaxant effect was significantly attenuated by removal of the endothelium and also by treatment with such nitric oxide (NO) synthase inhibitor L-NNA (10 M). Neither a prostacycline synthase inhibitor, indomethacin (10 M), nor a muscarinic receptor antagonist, atropine (10 M), altered the AJ-Ex induced endothelium-dependent relaxation. In conclusion, these antioxidant and vasorelaxant effects of the extracts may contribute to the beneficial effects in postmenopausal women.
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