왕머루포도 뿌리에서 분리한 heyneanol A의 신경보호효과
Neuroprotective Effect of Heyneanol A from the roots of vitis amurensis Rup
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Abstract
According to the report of Korea National Statistical Office in 2007, cerebral vascular disease is second cause of deaths in Korean. Cerebral ischemia is one of the main reason of cerebral vascular diseases. To evaluate the neuroprotective effect of heyneanol A against cerebral ischemia, we used the middle cerebral artery occlusion model (MCAO). Heyneanol A from root of vitis amurensis Rup is a tetramer of resveratrol as known anti-oxidant and anti-cancer agent. Although the effects of resveratrol in the various fields have been well established, little is known of the effects of heyneanol A. In this study, heyneanol A reduced infarction and edema volume by 33.5% and 57% compared with control groups (vehicle), respectively. Also, neurological score was decreased by heyneanol A. It's effects were more potent than resveratol. Taken together, these results exerted that heyneanol A has a neuroprotective effect against cerebral ischemia.
참고문헌 (16)
- "류종훈. 일시적 국부 뇌허혈 동물모델에서 한약재의 신경보호 효과", 34(4), pp.335~338 (2003)
- "이선미. 황기와 원지분획의 뇌허혈에 관한 약효연구", 44(4), pp.371~377 (2000)
- "The effects of Chinese herb Angelica in focal cerebral ischemia injury in the rat", 32(3), pp.209~215 (2005)
- "Oligostibenes from vitis heyneana", 42, pp.1163~1165 (1996)
- "Anti-inflammatory tetramers of resveratrol from the roots of Vitis amurensis and the conformations of the seven-membered ring in some oligostilbenes", 58, pp.357~362 (2001)
- "Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities", 27(10), pp.2059~2069 (2006)
- "Heyneanol A induces apoptosis via cytochrome c release and caspase activation in human leukemic U937 cells", 74(18), pp.2313~2326 (2004)
- "Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats", 71(6), pp.655~665 (2003)
- "Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation", 54(8), pp.3126~3131 (2006)
- "Resveratrol protects against global cerebral ischemic injury in gerbils", 958(2), pp.439~447 (2002)
- "Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia", 69(9), pp.1057~1065 (2001)
- "More on antioxidant activity of resveratrol in red wine", 42, pp.113~114 (1996)
- "Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?" (2007)
- "Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells", 30(6), pp.1130~1134 (2007)
- "Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model", 27(9), pp.1616~1622 (1996)
- "Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats", 74(8), pp.969~985 (2004)