馬尾連이 Alzheimer's Disease 病態 모델에 미치는 影響
The Effects of Thalictrum foetidum(TFD) on the Alzheimer's Disease Model
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Abstract
Objective : This experiment was designed to investigate the effect of Thalictrum foetidum(TFD) on the Alzheimer's disease. Method : The effects of TFD on amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by amyloid β protein(Aβ) and IL-1β, IL-6, TNF-α mRNA of THP-1 cell treated by lipopolysaccharide(LPS), AChE activity of PC-12 cell lysate treated by Aβ and behavior of the memory deficit mice induced by scopolamine, and glucose, AChE in serum of the memory deficit mice induced by scopolamine were investigated, respectively.Results : The results were summarized as follows ;1. TFD suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by Aβ.2. TFD suppressed IL-1β, IL-6, TNF-α mRNA in THP-1 cell treated by LPS.3.. TFD suppressed AChE activity in cell lysate of PC-12 cell treated by Aβ.4. TFD increased glucose and decreased AChE significantly in the serum of the memory deficit mice induced by scopolamine. 5. TFD group showed significantly inhibitory effect on the scopolamine-induced impairment of learning and memory in the experiment of Morris water maze. Conclusion : According to the above results, it is suggested that TFD might be usefully applied for prevention and treatment of Alzheimer's disease.
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