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黃柏이 Alzheimer's Disease 病態 모델에 미치는 영향

Effects of Phellodendron amurense Extract on the Alzheimer's Disease Model

정인철|이상룡|김영표
한의병리학회 (The Society of Pathology in Korean Medicine)|2005.02|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제19권 제1호|pp. 130-138

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참고문헌

주제분류한의학

초록

Abstract

This experiment was designed to investigate the effect of Phellodendron amurense(PLDA) on the Alzheimer's disease. The effects of PLDA extract on IL-1β, IL-6, amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by Aβ plus rIL-1β and AChE activity of PC-12 cell lysate treated by Aβ plus rIL-1β and behavior of memory deficit mice induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. PLDA extract suppressed IL-1β, IL-6, APP, AChE, GFAP mRNA in PC-12 cell treated by Aβ plus rIL-1β ; AChE activity in cell lysate of PC-12 cell treated by Aβ plus rIL-1β. PLDA extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. PLDA extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that PLDA extract might be usefully applied for prevention and treatment of Alzheimer's disease.

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