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비접촉경면현미경과 초음파 각막두께측정계를 이용해 측정한 중심각막두께의 비교

Comparison of Central Corneal Thickness Measurements between Noncontact Specular Microscopy and Ultrasound Pachymetry

이미연|신혜영|이영춘|온 경
대한안과학회 (The Korean Ophthalmological Society)|2019.07|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제60권 제7호|pp. 635-642

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키워드

Central corneal thicknessEndothelial cell densityUltrasound pachymetryNoncontact specular microscopy
주제분류안과학

초록

목적: 비접촉경면현미경(noncontact specular microscopy [NCSM])과 초음파 각막두께측정계(ultrasound pachymetry [USP])를 이용하여 중심각막두께(central corneal thickness, CCT) 측정값을 각막두께에 따라 비교 분석하여 임상적 유용성을 알아보고자 하였다. 대상과 방법: 120명 120안의 정상안을 대상으로 동일한 한 명의 검사자가 NCSM, USP의 순서로 CCT를 측정하였다. 각각의 검사기기로 측정된 CCT 측정치를 비교하였다. 검사기기 간의 일치도 및 상관관계를 분석하였다. 각막두께에 따라 검사 결과의 차이가 나타나는지 알아보기 위해 대상안을 USP로 측정한 CCT가 가장 얇은 환자부터 전체 대상자의 3분위수로 세 군으로 분류하여 두 검사기기로 측정된 CCT의 차(△CCT)를 분석하였다. 결과: NCSM 및 USP를 이용한 CCT 측정치는 각각 548.25 ± 40.64 μm, 533.09 ± 35.96 μm로 NCSM이 더 두껍게 측정되었고, 측정치 사이에 통계적으로 유의한 차이를 보였다(p<0.001). 두 검사는 높은 양의 상관관계를 보였다(r=0.878, p<0.01). 세 군에서의 NCSM과 USP로 측정한 CCT의 차(△CCT)는 각각 12.93 ± 21.88 μm, 16.85 ± 15.89 μm, 15.70 ± 20.46 μm로 세 군 간의 차이는 통계적으로 유의하지 않았다(p=0.655). 결론: 본 연구 결과 NCSM과 USP를 이용한 CCT 측정치는 각막두께에 상관없이 일정한 차이는 보이지만 높은 양의 상관관계를 보였다.

Abstract

Purpose: We compared and analyzed central corneal thickness (CCT) measurements according to the corneal thickness obtained with noncontact specular microscopy (NCSM) and ultrasound pachymetry (USP). Methods: CCT was measured in the order of NCSM and USP by a single optometrist in 120 eyes of 120 healthy subjects. The measurements were compared between the devices and the measurement agreements and correlations between the devices were analyzed. To determine if the measurements differed depending on the thickness of the cornea, the patients were divided into three tertile groups from the thinnest patient by CCT measurement using USP, and then the differences in CCT measured by the two devices were analyzed. Results: The CCT measurements using NCSM and USP were 548.25 ± 4.64 μm and 533.09 ± 35.96 μm, respectively. NCSM measurements were found to be thicker, showing statistically significant differences between the measurements (p < 0.001). The two examinations showed a high degree of correlation (r = 0.878; p < 0.01). In the three groups, the differences in CCT measurements between NCSM and USP were 12.93 ± 21.88 μm, 16.85 ± 15.89 μm, and 15.70 ± 20.46 μm, respectively, but the differences between the three groups were not statistically significant (p = 0.655). Conclusions: Our results show that although the differences in CCT measurements using NCSM and USP were consistent regardless of the corneal thickness, the CCT measurements by NCSM and USP were highly correlated.

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