중심각막두께측정에 대한 비접촉경면현미경의 유용성
Utility of the Noncontact Specular Microscopy for Measurements of Central Corneal Thickness
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목적: 비접촉경면현미경으로 측정한 중심각막두께를 전안부 빛간섭단층촬영계와 초음파 각막두께측정계를 이용한 측정값과 비교하여유용성을 알아보고자 한다. 대상과 방법: 정상인 50명 50안을 대상으로 동일한 검사자에 의해 비접촉경면현미경, 전안부 빛간섭단층촬영계 그리고 초음파 각막두께측정계를 이용하여 측정된 중심각막두께를 비교하고 각각의 상관관계를 알아보았다. 결과: 비접촉경면현미경을 이용하여 측정한 중심각막두께의 평균값은 546.92 ± 32.06 μm였고, 전안부 빛간섭단층촬영계는 535.24± 30.54 μm, 초음파 각막두께측정계는 546.38 ± 30.70 μm였다. 비접촉경면현미경과 초음파 각막두께측정계를 이용한 측정치가전안부 빛간섭단층촬영계를 이용한 측정치보다 유의하게 두껍게 측정되었으나(p＜0.001, p＜0.001) 비접촉경면현미경과 초음파 각막두께측정계를 이용한 측정치 간에는 통계적으로 유의한 차이가 없었다(p=0.505). 세 검사기기에서 높은 상관관계를 보였다(r＞0.900in all groups, p＜0.001 in all groups). 결론: 정상안에서 비접촉경면현미경로 측정한 중심각막두께가 전안부 빛간섭단층촬영계를 이용한 경우보다 초음파 각막두께측정계로측정한 값에 좀더 유사한 값을 나타냈다. 정상안의 중심각막두께 측정에 비접촉경면현미경이 전안부 빛간섭단층촬촬영계보다 초음파각막두께측정계를 대체할 수 있는 좀더 유용한 방법이라 생각된다.
Abstract
Purpose: To evaluate the efficacy of noncontact specular microscopy (NCSM) by comparing the measurement of centralcorneal thickness (CCT) to the measurement with anterior segment optical coherence tomography (AS-OCT) and ultrasoundpachymetry (USP). Methods: One examiner measured the CCT of 50 eyes of 50 healthy young subjects using NCSM, AS-OCT, and USP. Themean values and correlations were analyzed. Results: The mean CCT value was 546.92 ± 32.06 μm with NCSM, 535.24 ± 30.54 μm with AS-OCT, and 546.38 ± 30.70 μmwith USP. The CCT measurements with NCSM and USP were significantly thicker than with AS-OCT (p < 0.001, p < 0.001,respectively). There were no significant differences between the measurements obtained with NCSM and USP (p = 0.505). The 3 instruments were significantly correlated (r > 0.900 in all groups, p < 0.001 in all groups). Conclusions: CCT measurements of healthy eyes using NCSM are more correlated with USP than AS-OCT. The CCTmeasurement using NCSM is a better alternative for USP than AS-OCT.
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