두 가지 스펙트럼영역 빛간섭단층촬영기, 펜타캠, 초음파각막측정계로 측정한 중심각막두께 비교
Corneal Thickness Measurements Using 2 Kinds of Spectral Domain Optical Coherence Tomography, Pentacam, Ultrasound Pachymetry
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목적: 정상안에서 두 가지 스펙트럼영역 빛간섭단층촬영기(optical coherence tomography, OCT), Pentacam®, 초음파각막측정계로 측정한 중심각막두께(central corneal thickness, CCT)를 비교하고자 하였다. 대상과 방법: 전안부 질환이 없는 건강인 32명을 대상으로 Cirrus OCT®, Spectralis OCT®, Pentacam®, 초음파각막측정계를 통하여 중심각막두께를 측정하고 각 장비 간 측정값을 비교하였다. 결과: Cirrus OCT®, Spectralis OCT®, Pentacam®, 초음파각막측정계(ultrasound pachymetry, USP)로 측정한 평균 중심각막두께는 각각 549.2 ± 28.7 μm, 545.2 ± 25.4 μm, 554.0 ± 27.8 μm, 548.4 ± 27.9 μm였다. 모든 측정치는 서로 통계적으로 유의하게 높은 상관관계를 보였으나(Pearson correlation coefficient r>0.9, all p-value<0.001) 각 측정치 사이에는 통계적으로 유의한 차이가 있었다(p<0.001). 네 가지 검사 방법 간 일치도 분석 결과 Cirrus OCT®와 Spectralis OCT® 간의 95% 일치도 범위는 27.70 μm, Cirrus OCT®와 Pentacam®은 26.1 μm, Cirrus OCT®와 초음파각막측정계는 26.97 μm, Spectralis OCT®와 Pentacam®은 22.91 μm, Spectralis OCT®와 초음파각막측정계는 35.59 μm, Pentacam®과 초음파각막측정계는 32.15 μm였다. 결론: 네 가지 기기를 이용한 중심각막두께의 측정값들은 서로 강한 상관관계를 보였으나 초음파각막측정계에 비하여 Pentacam®의 경우 유의하게 두껍게 측정되었고, 두 가지 빛간섭단층촬영기(OCT)로 측정한 측정값은 초음파각막측정계로 측정한 값에 좀 더 유사한 값을 나타내어 중심각막두께 측정 결과 적용 시 이에 대한 고려가 필요하며 각 기기들의 측정값 사이에는 차이가 있어 호환하여 사용하기 어려울 것으로 보인다.
Abstract
Purpose: To compare the measurements of central corneal thickness (CCT) obtained using two kinds of spectral domain optical coherence tomography (OCT), Pentacam®, and ultrasound pachymetry (USP). Methods: CCT was measured by Cirrus OCT®, Spectralis OCT®, Pentacam®, and USP in 32 eyes from 32 subjects without ocular disease of the anterior segment. Results: The average CCT measurements using Cirrus OCT®, Spectralis OCT®, Pentacam®, and USP were 549.2 ± 28.7 μm, 545.2 ± 25.4 μm, 554.0 ± 27.8 μm, and 548.4 ± 27.9 μm respectively. The measurements were significantly highly correlated with each other (Pearson’s correlation coefficient r > 0.9, all p-values < 0.001), but were significantly different (p < 0.001). The CCT 95% limits of agreement between Cirrus OCT® and Spectralis OCT®, Cirrus OCT® and Pentacam®, Cirrus OCT® and USP, Spectralis OCT® and Pentacam®, and Spectralis OCT® and USP were 27.70 μm, 26.1 μm, 26.97 μm, 22.91 μm, 35.59 μm, and 32.15 μm, respectively. Conclusions: The CCT values measured using the four devices were highly correlated with each other, but the measurement using Pentacam® was significantly thicker than that using USP. The measurements of the two kinds of spectral domain OCT were similar to those using USP. Therefore, these differences should be considered in clinical use, and measurements cannot be considered interchangeable.
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