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In vitro biological evaluation of 100 selected methanol extracts from the traditional medicinal plants of Asia

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BACKGROUND/OBJECTIVES: In Asia, various medicinal plants have been used as the primary sources in the health care regimenfor thousands of years. In recent decades, various studies have investigated the biological activity and potential medicinalvalue of the medicinal plants. In this study, 100 methanol extracts from 98 plant species were evaluated for their biologicalactivities. MATERIALS/METHODS: The research properties, including 1,1-diphenyl-2-pic-rylhydrazyl (DPPH) radical scavenging activity, α-glucosidase and α-tyrosinase inhibitory effects, anti-inflammatory activity, and anticancer activity were evaluated for the selectedextracts. RESULTS: Fifteen of the extracts scavenged more than 90% of the DPPH radical. Among the extracts, approximately 20 extractsshowed a strong inhibitory effect on α-glucosidase, while most had no effect on α-tyrosinase. In addition, 52% of the extractsshowed low toxicity to normal cells, and parts of the extracts exhibited high anti-inflammatory and anticancer activities onthe murine macrophage cell (RAW 264.7) and human colon cancer cell (HT-29) lines, respectively. CONCLUSIONS: Our findings may contribute to further nutrition and pharmacological studies. Detailed investigations of theoutstanding samples are currently underway.

Abstract

BACKGROUND/OBJECTIVES: In Asia, various medicinal plants have been used as the primary sources in the health care regimenfor thousands of years. In recent decades, various studies have investigated the biological activity and potential medicinalvalue of the medicinal plants. In this study, 100 methanol extracts from 98 plant species were evaluated for their biologicalactivities. MATERIALS/METHODS: The research properties, including 1,1-diphenyl-2-pic-rylhydrazyl (DPPH) radical scavenging activity, α-glucosidase and α-tyrosinase inhibitory effects, anti-inflammatory activity, and anticancer activity were evaluated for the selectedextracts. RESULTS: Fifteen of the extracts scavenged more than 90% of the DPPH radical. Among the extracts, approximately 20 extractsshowed a strong inhibitory effect on α-glucosidase, while most had no effect on α-tyrosinase. In addition, 52% of the extractsshowed low toxicity to normal cells, and parts of the extracts exhibited high anti-inflammatory and anticancer activities onthe murine macrophage cell (RAW 264.7) and human colon cancer cell (HT-29) lines, respectively. CONCLUSIONS: Our findings may contribute to further nutrition and pharmacological studies. Detailed investigations of theoutstanding samples are currently underway.

참고문헌 (35)

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