본문 바로가기
KERD
논문KCI 등재

Antioxidant and Anticancer Activities of Leaves Extracts from Acer tegmentosum

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

초록

In this study, we were performed to elucidate the antioxidant and anticancer activity by leaves extracts from Acertegmentosum (AT-L). In DPPH, ABTS radical scavenging activity, the AT-L revealed the high scavenging activity. Especially, the AT-L measured the highest ABTS radical scavenging activity, which is higher than ascorbic acid. The typesof human cancer cells for evaluating the anticancer activity were colorectal cancer (SW480), prostate cancer (PC-3), breastcancer (MCF-7), pancreatic cancer (AsPC-1), lung cancer (A549) and liver cancer (HepG2). Human cancer cell viabilitywas measured using MTT assay. Treatment of the AT-L decreased the cell viability and induced apoptosis in SW480 cells. These results suggest that extracts of the AT-L can be used as supplementary material for developing the natural antioxidantand anticancer drug for human cancer cells.

Abstract

In this study, we were performed to elucidate the antioxidant and anticancer activity by leaves extracts from Acertegmentosum (AT-L). In DPPH, ABTS radical scavenging activity, the AT-L revealed the high scavenging activity. Especially, the AT-L measured the highest ABTS radical scavenging activity, which is higher than ascorbic acid. The typesof human cancer cells for evaluating the anticancer activity were colorectal cancer (SW480), prostate cancer (PC-3), breastcancer (MCF-7), pancreatic cancer (AsPC-1), lung cancer (A549) and liver cancer (HepG2). Human cancer cell viabilitywas measured using MTT assay. Treatment of the AT-L decreased the cell viability and induced apoptosis in SW480 cells. These results suggest that extracts of the AT-L can be used as supplementary material for developing the natural antioxidantand anticancer drug for human cancer cells.

참고문헌 (30)

  1. Alao, J. P, "The regulation of cyclin D1 degradation : Roles in cancer development and the potential for therapeutic invention", Mol. Cancer, 6(1), pp.24~ (2007)
  2. Blois, M. S, "Antioxidant determinations by the use of a stable free radical", Nature, 181(4617), pp.1199~1200 (1958)
  3. Choi, G. E., "Inhibitory effect of Acer tegmentosum maxim extracts on P. gingivalis LPS-induced periodontitis", Arch. Oral. Biol., 109, pp.104529~104534 (2020)
  4. Gupta, V., "Evaluation of anticancer agents using flowcytometry analysis of cancer stem cells", Methods Mol. Biol, 716, pp.179~191 (2011)
  5. Halliwell, B., "Free radicals, antioxidants, and human disease: Where are we now?", J. Lab. Clin. Med, 119(6), pp.598~620 (1992)
  6. Haq, S. H., "Antioxidant, anticancer activity and phytochemical analysis of green algae, Chaetomorpha collected from the Arabian gulf", Sci. Rep., 9(1), pp.18906~18912 (2019)
  7. 홍보경, "산겨릅나무 줄기추출물의 생리활성 및 유효성분 분리", 한국약용작물학회지, 15(4), pp.296~303 (2007), 한국약용작물학회
  8. Huang, D., "The chemistry behind antioxidant capacity assays", J. Agri. Food Chem, 53, pp.1841~1856 (2005)
  9. 허종문, "산겨릅나무 줄기에서 이소프렌계 화합물의 분리", 생약학회지, 38(1), pp.67~70 (2007), 한국생약학회
  10. 진동혁, "와송(Orostachys japonicus A. Berger) 추출물의 총 페놀, 플라보노이드 함량 및 항산화 활성 비교", 한국환경과학회지, 25(5), pp.695~703 (2016), 한국환경과학회[DOI]
  11. 강연경, "인간 대장암 세포에 대한 먹넌출 추출물의 GSK3β의존성 threonine-286 인산화를 통한 Cyclin D1 분해", 한국자원식물학회지, 33(4), pp.271~278 (2020), 한국자원식물학회
  12. 김억천, "Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo", Journal of Korean Medical Science, 30(7), pp.979~987 (2015), 대한의학회
  13. 김성훈, "산겨릅나무에서 분리한 salidroside의 간보호 효과", 동의생리병리학회지, 22(6), pp.1525~1531 (2008), 한의병리학회
  14. Kim, S., "Antioxidant and anti-inflammatory compounds isolated from Acer tegmentosum", J. Med. Plants Res, 6, pp.3971~3976 (2012)
  15. Knudsen, K. E., "Cyclin D1: Polymorphism, aberrant splicing and cancer risk", Oncogene, 25, pp.1620~1628 (2006)
  16. 권동주, "산겨릅나무 목질부에서 분리한 페놀성 화합물의 DPPH 라디칼 소거활성", 목재공학, 39(1), pp.104~112 (2011), 한국목재공학회
  17. 이진욱, "Anti-oxidant and anti-inflammatory activities of the various kinds of herbal tea", 대한본초학회지, 29(2), pp.1~6 (2014), 대한본초학회
  18. Luthria, D. L., "Bioactive phytochemicals in wheat: Extraction, analysis, processing, and functional properties", J. Func. Food, 18, pp.910~925 (2015)
  19. 노종현, "천초근 에탄올 추출물의 항산화 효능 및 대장암 세포 억제 효과", 한국자원식물학회지, 31(2), pp.102~108 (2018), 한국자원식물학회[DOI]
  20. Ki Myun Park, "Cytotoxic Phenolic Constituents of Acer tegmentosum Maxim", Archives of Pharmacal Research, 29(12), pp.1086~1090 (2006), 대한약학회
  21. 박수빈, "독활 에탄올 추출물의 대장암 세포에서 Cyclin D1 단백질 분해 유도를 통한 세포 생육 억제활성", 한국약용작물학회지, 25(5), pp.328~334 (2017), 한국약용작물학회[DOI]
  22. 박성진, "벌나무 잎의 영양성분 및 이화학 특성", Culinary Science & Hospitality Research, 22(8), pp.27~38 (2016), (사)한국조리학회[DOI]
  23. Pozarowski, P., "Analysis of cell cycle by flow cytometry", Methods Mol. Biol, 208(2), pp.301~311 (2004)
  24. Re, R., "Antioxidant activity applying an improved ABTS radical cation decolorization assay", Free Radic. Biol. Med., 26(9-10), pp.1231~1237 (1999)
  25. Shang, S., "The regulation of β-catenin activity and function in cancer : Therapeutic opportunities", Oncotarget, 8(20), pp.33972~33989 (2017)
  26. Singleton, V. L., "Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent", Methods Enzymol, 299, pp.152~178 (1999)
  27. 송나영, "산겨릅나무로부터 페놀화합물의 분리 및 항염증 활성의 측정", 생약학회지, 45(2), pp.93~100 (2014), 한국생약학회
  28. Wlodkowic, D., "Flow cytometry-based apoptosis detection", Methods Mol. Biol, 559, pp.19~32 (2009)
  29. Woisky, R. G., "Analysis of propolis : Some parameters and procedures for chemical quality control", J. Apic. Res, 37(2), pp.99~105 (1998)
  30. Yu, T., "In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum", J. Ethnopharmacol, 128(1), pp.139~147 (2010)

관련 논문AI추천

이 간행물의 다른 논문 (16건)