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常山이 Alzheimer's Disease 病態 모델에 미치는 影響

The Effects of Dichroa febrifuga(DIF) Extract on the Alzheimer's Disease Model

정인철|이상룡|이승희
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2005.06|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제16권 제1호|pp. 81-96

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참고문헌

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초록

Abstract

This experiment was designed to investigate the effect of Dichroa febrifuga(DIF) on the Alzheimer's disease. The effects of DIF extract on IL-1β, IL-6, TNF-α mRNA of THP-1 cell treated by Aβ plus LPS and amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by Aβ plus rIL-1β and AChE activity of PC-12 cell lysate treated by Aβ plus rIL-1β and behavior of memory deficit mice induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. The results were summarized as follows ; 1. DIF extract suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by Aβ. 2. DIF extract suppressed IL-1β, IL-6, TNF-α mRNA in THP-1 cell treated by LPS. 3. DIF extract suppressed AChE activity in cell lysate of PC-12 cell treated by Aβ. 4. DIF extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. 5. DIF extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that DIF extract might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit.

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