大黃이 Alzheimer's Disease 病態 모델에 미치는 影響
The Effects of Rheum palmatum(RHP) Extract on the the Alzheimer's Disease Model
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참고문헌
초록
Abstract
This experiment was designed to investigate the effect of Rheum palmatum(RHP) on the Alzheimer's disease. The effects of RHP extract on amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by Aβ and IL-1β, IL-6, TNF-α mRNA of THP-1 celll treated by LPS and AChE activity of PC-12 cell lysate treated by Aβ and behavior of memory deficit rats induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. The results were summarized as follows ; 1. RHP extract suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by Aβ . 2. RHP extract suppressed IL-1β, IL-6 TNF-α mRNA in THP-1 celll treated by LPS. 3. RHP extract suppressed AChE activity in cell lysate of PC-12 cell treated by Aβ. 4. HP extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. 5. RHP extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that RHP extract might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit symptom.
참고문헌 (23)
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