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杜鵑花가 Alzheimer's Disease 病態 모델에 미치는 影響

The Effects of Rhododendron simsii Planch(RSP) on the Alzheimer's Disease Model

정인철|이상룡|장진실
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2006.07|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제17권 제2호|pp. 75-89

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참고문헌

주제분류한의학

초록

Abstract

Objective : This experiment was designed to investigate the effect of Rhododendron simsii Planch(RSP) on the Alzheimer's disease. Method : The effects of RSP on amyloid precursor proteins(APP), acetylcholinesterase (AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by amyloid β protein(Aβ) and IL-1β, IL-6, TNF-α mRNA of THP-1 cell treated by lipopolysaccharide(LPS), AChE activity of PC-12 cell lysate treated by Aβ and behavior of the memory deficit mice induced by scopolamine, and glucose, AChE in serum of the memory deficit mice induced by scopolamine were investigated, respectively. Result : 1. RSP suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by Aβ.2. RSP suppressed IL-1β, IL-6, TNF-α mRNA in THP-1 cell treated by LPS.3. RSP suppressed AChE activity in cell lysate of PC-12 cell treated by Aβ.4. RSP increased glucose and decreased AChE significantly in the serum of the memory deficit mice induced by scopolamine. 5. RSP group showed significantly inhibitory effect on the scopolamine-induced impairment of learning and memory in the experiment of Morris water maze. Conclusion : According to the above results, it is suggested that RSP might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit symptom.

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常山이 Alzheimer's Disease 病態 모델에 미치는 影響이상룡, 이승희, 정인철대한한방신경정신과학회 · 동의신경정신과학회지2005 · 제16권 제1호山査肉이 Alzheimer's Disease 病態 모델에 미치는 영향이상룡, 정인철한의병리학회 · 동의생리병리학회지2002 · 제16권 제2호大黃이 Alzheimer's Disease 病態 모델에 미치는 影響박철환, 이상룡, 정인철대한한방신경정신과학회 · 동의신경정신과학회지2005 · 제16권 제1호馬尾連이 Alzheimer's Disease 病態 모델에 미치는 影響배재용, 이상룡, 정인철대한한방신경정신과학회 · 동의신경정신과학회지2007 · 제18권 제1호목근피가 CT105와 Ba로 유도된 Alzheimer's Disease 병태모델에 미치는 영향이상룡, 정인철, 최병만대한한방신경정신과학회 · 동의신경정신과학회지2004 · 제15권 제2호黃柏이 Alzheimer's Disease 病態 모델에 미치는 영향김영표, 이상룡, 정인철한의병리학회 · 동의생리병리학회지2005 · 제19권 제1호

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