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大造丸 추출물이 β-amyloid로 유도된 Alzheimer's disease 病態모델에 미치는 영향

The Effects of Daejo-hwan(DJH) on the Alzheimer's Disease Model Induced by β-amyloid.

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Abstract

Objective : This study was performed to examine the anticonvulsant effects of the extracts of JeongGan-Tang and explanation of its action mechanism. Method :1) The inhibitory effect on convulsions induced by pentylenetetrazole, picrotoxin and strychnine was investigated in vivo2) The inhibitory effect on GABA transaminase activity was evaluated in vivo and in vitro.3) The brain GABA level and glutamate level in pentylenetetrazole-induced convulsion model were analyzed by HPLC,

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