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連翹升麻湯이 함유된 한방화장품이 아토피 피부염에 미치는 임상 연구

A Clinical Research of Atopic Dermatitis treated by Yeongyuseungmatang in cosmetics

김희택|윤경섭|김성호|윤대철|호동수
대한한방안이비인후피부과학회 (The Korean Medicine Opthalmology&Otolaryngology&Dermatology Society)|2008.08|한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology)|제21권 제2호|pp. 126-141

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참고문헌

키워드

Atopic DermatitisTEWLcosmeticsTotal IgEexternal applicationEosinophil countYeongyuseungmatangSkin TemperatureSkin HydrationSkin pH
주제분류한의학

초록

Objective:This clinical research was conducted to test patients with Atopic Dermatitis by external application with Yeongyuseungmatang in cosmetics. Methods:We gave scores to 33 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung Jecheon Oriental Medical Hospital from April 17th, 2008 to June 12th. Seventeen patients were treated with Yeongyuseungmatang(Experimental group) and sixteen patients were treated with Atopico skin care cream(Control group) for 4weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinic Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Yeongyuseungmatang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). Results:1.After 4 weeks of external application treatment, SCORAD Index in Yeongyuseungmatang was significant statistically decreased compared with control group. 2.After 4 weeks of external application treatment, eosinophil count in Yeongyuseungmatang was significant statistically decreased compared with control group but total IgE was very increased both Yeongyuseungmatang and control group. 3.Statistically, Yeongyuseungmatang and control group didn't showed significant effect on Skin Temperature was measured by Thermometer SM815. 4.Transepidermal Water Loss(TEWL) in Yeongyuseungmatang was significant statistically decreased compared with control group measured by Tewameter TM300. 5.Skin Hydration in Yeongyuseungmatang was significant statistically increased compared with control group measured by Corneometer CM825. 6.Statistically, Yeongyuseungmatang and control group didn't showed significant effect on Skin pH was measured by Skin-pH-Meter PH905. 7.After 4 weeks of external application treatment, Yeongyuseungmatang showed significant effect on global assesment of efficacy. Conclusion : Considering the above results, we can speculate that cosmetics with Yeongyuseungmatang has some therapeutical effects in mitigating the symptoms of atopic dermatitis.

Abstract

Objective:This clinical research was conducted to test patients with Atopic Dermatitis by external application with Yeongyuseungmatang in cosmetics. Methods:We gave scores to 33 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung Jecheon Oriental Medical Hospital from April 17th, 2008 to June 12th. Seventeen patients were treated with Yeongyuseungmatang(Experimental group) and sixteen patients were treated with Atopico skin care cream(Control group) for 4weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinic Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Yeongyuseungmatang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). Results:1.After 4 weeks of external application treatment, SCORAD Index in Yeongyuseungmatang was significant statistically decreased compared with control group. 2.After 4 weeks of external application treatment, eosinophil count in Yeongyuseungmatang was significant statistically decreased compared with control group but total IgE was very increased both Yeongyuseungmatang and control group. 3.Statistically, Yeongyuseungmatang and control group didn't showed significant effect on Skin Temperature was measured by Thermometer SM815. 4.Transepidermal Water Loss(TEWL) in Yeongyuseungmatang was significant statistically decreased compared with control group measured by Tewameter TM300. 5.Skin Hydration in Yeongyuseungmatang was significant statistically increased compared with control group measured by Corneometer CM825. 6.Statistically, Yeongyuseungmatang and control group didn't showed significant effect on Skin pH was measured by Skin-pH-Meter PH905. 7.After 4 weeks of external application treatment, Yeongyuseungmatang showed significant effect on global assesment of efficacy. Conclusion : Considering the above results, we can speculate that cosmetics with Yeongyuseungmatang has some therapeutical effects in mitigating the symptoms of atopic dermatitis.

참고문헌 (37)

  1. Hanifin JM, "Atopic dermatitis in infants and children", Pediatr Clin North Am, 38, pp.763~89 (1991)
  2. Leung DYM, "Atopic dermatitis, Dermatology in general medicine. 6th", pp.1180~94 (2003), New York: McGraw-Hill
  3. 권지애, "한국인 청장년기 아토피피부염 환자의 임상적 특징에 관한 연구", 대한피부과학회지, 42(8), pp.949~954 (2004), 대한피부과학회
  4. Finlay AY, "Quality of life in atopic dermatitis", J Am Acad Dermatol, 45(1), pp.S64~6 (2001)
  5. 이희정, "성인 아토피피부염 환자에서 삶의 질 평가의 임상적 유용성", 대한피부과학회지, 45(2), pp.159~164 (2007), 대한피부과학회
  6. Baumann L, "Topical glucocorticoids, Dermatology in general medicine. 5th", pp.2713~7 (1999), New York : McGraw-Hill
  7. 張介賓, "李南九 懸吐註釋", pp.1225~ (2007), 懸吐註釋 景岳全書. 서울:법인문화사
  8. Hanifin JM, "Diagnostic features of atopic dermatitis", Acta Derm Venereol, 92(144), pp.44~7 (1980)
  9. Consensus Report of the European Task Force on Atopic Dermatitis, "Severity Scoring of Atopic Dermatitis", The SCORAD Index. Dermatology, 186, pp.23~31 (1993)
  10. 이유신, "임상피부과학", pp.22~7 (1998), 서울:여문각
  11. 대한 피부과학회 교과서 편찬 위원회, "피부과학", pp.161~6 (2001), 서울:여문각
  12. 안성구, "common Skin Disease", pp.70~4 (2005), 서울:퍼시픽 출판사
  13. 최인화, "아토피 피부염에 관한 임상적 연구", 대한한의사협회지, 12(1), pp.73~83 (1991)
  14. 공남미, "아토피 피부염의 양 한방적 고찰", 대한외관과학회지, 12, pp.241~53 (1999)
  15. 趙純修, "中醫皮膚病學", pp.110~2 (1999), 北京:科學出版社
  16. 顧伯華, "實用中醫外科學", pp.460~4 (1996), 上海:上海科學技術出版社
  17. 박민철, "아토피 피부염의 동서의학적 문헌 고찰", 15(1), pp.226~52 (2002)
  18. 朴志修, "아토피 환자의 식이요법 및 외용요법의 조사와 체질별 적용", 대한한방소아과학회지, 17(2), pp.85~101 (2003)
  19. 장은영, "소아 아토피피부염에서의 대체보완요법 이용에 관한 연구", 천식 및 알레르기, 25(2), pp.110~116 (2005), 대한알레르기학회
  20. 김창훈, "아토피 피부염 환자에서 한방 추출물이 포함된 외용제품에 대한 임상 효과", 한방안이비인후피부과학회지, 20(2), pp.187~198 (2007), 대한한방안이비인후피부과학회
  21. 김창훈, "한방 샴푸", 에센스의 비듬에 대한무작위배정, 이중맹검, 위약 대조군 연구, 2007, pp.20(3), 222~235[DOI]
  22. 황순이, "아토피 피부염 환자에서 七葉膽을 함유한 화장품의 임상적 연구", 한방안이비인후피부과학회지, 20(3), pp.212~221 (2007), 대한한방안이비인후피부과학회
  23. Flynn TC, "Dry skin and moisturizers", Clin Dermatol, 19(4), pp.387~92 (2001)
  24. Loden M, "Dry skin and moisturizers: Chemistry and Function" (2000), Boca Raton, FL: CRC Press
  25. 김미진, "연교추출물의 피부 항노화 효과", 한국생물공학회지, 21(6), pp.444~450 (2006), 한국생물공학회
  26. 유복종, "Effect of Forsythiae Fructus Extract on the Release of Inflammatory Mediatorinduced by Lipopolysaccharide in RAW 264.7 Macrophage", 동의생리병리학회지, 21(3), pp.765~70 (2007)
  27. 신태용, "승마 추출물의 항알레르기 효과", 藥學會誌, 42(4), pp.403~7 (1998)
  28. 김시나, "갈근 추출물에 의한 염증성 cytokine 생성 억제 및 prostaglandin E₂ 활성 저해에 관한 연구", 한국식품영양과학회지, 35(1), pp.28~34 (2006)
  29. 김성수, "桔梗에 의한 알레르기 천식효과에 대한 연구", 대한본초학회지, 19(2), pp.61~70 (2004), 대한본초학회
  30. 이정숙, "4종의 한약 추출물이 염증치료 및 예방에 미치는 영향에 대한 연구", 한방안이비인후피부과학회지, 17(2), pp.31~8 (2004)
  31. 정희재, "金銀花와 白芍藥이 BEAS-2B 인간 기관지상피세포의 Cytokines mRNA level에 미치는 影響", 대한한의학회지, 24(3), pp.575~584 (2003), 대한한의학회
  32. 최유성, "아토피피부염의 중증도에 따른 임상 및 검사실 소견에 관한 연구", 대한피부과학회지, 44(7), pp.824~829 (2006), 대한피부과학회
  33. 김명남, "아토피 피부염에서 말초 혈액내 호산구 수, 혈청 총 IgE, eosinophil cationic proteinm, IL-4 및 soluble E-selection의 변화", 대한피부과학회지, 40(11), pp.1367~73 (2002)
  34. Kim DW, "Correlation of clinical features and skin barrier function in adolescent and adult patients with atopic dermatitis", Int J Dermatol, 45(6), pp.698~701 (2006)
  35. 장윤환, "Tape Stripping에 의한 각질층 제거 정도에 따른 피부장벽기능의 변화", 대한피부과학회지, 43(7), pp.919~925 (2005), 대한피부과학회
  36. 신경열, "Tapte Stripping과 Sodium Lauryl Sulfate에 의한 피부 장벽기능의 손상 및 회복에 관한 연구", 대한피부과학회지, 38(2), pp.183~90 (2000)
  37. 소병화, "피부효과의 기기평가", 한국 피부장벽학회지, 8(1), pp.68~75 (2006)

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