본문 바로가기
KERD
논문KCI 등재

苦蔘, 枳實, 荊芥, 連翹, 馬齒莧 추출물이 포함된 외용제의 아토피 피부염에 대한 유효성 평가를 위한 임상연구

Clinical Study for the Efficacy of External Preparation Containing Sophorae Radix, Aurantii Immaturus Fructus, Schizonepetae Spica, Forsythia fructus and Portulacea Herba Extract on Atopic Dermatitis

정현아|김경한
대한한방안이비인후피부과학회 (The Korean Medicine Opthalmology&Otolaryngology&Dermatology Society)|2014.02|한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology)|제27권 제1호|pp. 17-36

2

조회

0

다운로드

8

인용

0

참고문헌

키워드

Atopic dermatitisExternal applicationSCORAD indexSophorae RadixAurantii Immaturus FructusSchizonepetae SpicaForsythia fructusPortulacea Herba
주제분류한의학

초록

Objectives : The purpose of this study is to investigate the efficacy of external preparation containing herbalextract(Sophorae Radix, Aurantii Immaturus Fructus, Schizonepetae Spica, Forsythia fructus and Portulacea Herba) onatopic dermatitis patients. Methods : A total of 33 patients who visited the Dept. of Ophthalmology, Otolaryngology & Dermatology of KoreanMedicine of Korean Medical hospital of Daejeon university from February 2012 to February 2013 were engaged in thisstudy. Patients who corresponded the requirements were enrolled in the study. This study shows symptom comparisonsbefore and after the use of this product. Effectiveness was evaluated through SCORAD(SCORing Atopic Dermatitis) Index,and the quality of life scale was conducted through Skindex-29. Results : 1. Comparison of the general changes through SCORAD Index indicated that the experimental group showedmore statistically significant declines than the placebo group after the two-week use. 2. Comparison of changes in intensity criteria(Erythema, Edema, Oozing, Excoriation) through SCORAD Indexindicated that the experimental group showed more statistically significant declines than the placebo groupafter the two-week use. 3. Comparison of changes in subjective symptoms through SCORAD Index indicated that the experimentalgroup showed no statistically remarkable changes. 4. Comparison of changes in the body parts(Upperlimb) through SCORAD Index indicated theexperimental group showed statistically significant changes after the two-week use. 5. Comparison of the general changes in quality of life through Skindex-29 indicated that the total scorefrom experimental group showed statistically significant changes after the four-week use. Conclusions: This study, evaluated through SCORAD Index, indicated that the treatment with the external preparationcontaining herbal extract has a statistically marginal significance of efficacy on atopic dermatitis patients in the short term.

Abstract

Objectives : The purpose of this study is to investigate the efficacy of external preparation containing herbalextract(Sophorae Radix, Aurantii Immaturus Fructus, Schizonepetae Spica, Forsythia fructus and Portulacea Herba) onatopic dermatitis patients. Methods : A total of 33 patients who visited the Dept. of Ophthalmology, Otolaryngology & Dermatology of KoreanMedicine of Korean Medical hospital of Daejeon university from February 2012 to February 2013 were engaged in thisstudy. Patients who corresponded the requirements were enrolled in the study. This study shows symptom comparisonsbefore and after the use of this product. Effectiveness was evaluated through SCORAD(SCORing Atopic Dermatitis) Index,and the quality of life scale was conducted through Skindex-29. Results : 1. Comparison of the general changes through SCORAD Index indicated that the experimental group showedmore statistically significant declines than the placebo group after the two-week use. 2. Comparison of changes in intensity criteria(Erythema, Edema, Oozing, Excoriation) through SCORAD Indexindicated that the experimental group showed more statistically significant declines than the placebo groupafter the two-week use. 3. Comparison of changes in subjective symptoms through SCORAD Index indicated that the experimentalgroup showed no statistically remarkable changes. 4. Comparison of changes in the body parts(Upperlimb) through SCORAD Index indicated theexperimental group showed statistically significant changes after the two-week use. 5. Comparison of the general changes in quality of life through Skindex-29 indicated that the total scorefrom experimental group showed statistically significant changes after the four-week use. Conclusions: This study, evaluated through SCORAD Index, indicated that the treatment with the external preparationcontaining herbal extract has a statistically marginal significance of efficacy on atopic dermatitis patients in the short term.

참고문헌 (34)

  1. Rho SS, "Full-color Dermatology", pp.499~ (2006), IBC Design
  2. Fitzpatrick Thomas B, "Color atlas and synopsis of Clinical Dermatology", pp.54~63 (1999), Jungdam
  3. Hanifin JM, "Diagnostic features of atopic dermatitis", Acta Derm Venereol, 92(suppl. 144), pp.44~47 (1980)
  4. 박영립, "아토피피부염 학회보고서: 한국인 아토피피부염의 진단기준에 대한 연구", 대한피부과학회지, 44(6), pp.659~663 (2006), 대한피부과학회
  5. College of Korean medicine Ponch'ohak Committee, "Ponch'ohak", pp.159~160 (2004), Youngrim
  6. Yoon HS, "Eight Cases of Atopic Dermatitis Treated with No-Hoe(Aloe vera L.) Extract Dressing", The Journal of Korean Oriental Medical Ophthalmology &Otolaryngology & Dermatology, 17(3), pp.153~166 (2004)
  7. 김창훈, "아토피 피부염 환자에서 한방 추출물이 포함된 외용제품에 대한 임상 효과", 한방안이비인후피부과학회지, 20(2), pp.187~198 (2007), 대한한방안이비인후피부과학회
  8. 황순이, "아토피 피부염 환자에서 七葉膽을 함유한 화장품의 임상적 연구", 한방안이비인후피부과학회지, 20(3), pp.212~221 (2007), 대한한방안이비인후피부과학회
  9. 홍원규, "소아 아토피 피부염에서 발아현미 상황버섯의 임상적 치료효과", 대한본초학회지, 23(1), pp.103~108 (2008), 대한본초학회
  10. European Task Force on Atopic Dermatitis, "Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis", Dermatology, 186(1), pp.23~31 (1993)
  11. Charman C, "Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring?", J Invest Dermatol, 120(6), pp.932~941 (2003)
  12. 안봉균, "피부과 환자의 삶의 질 평가를 위한 한국어판 Skindex-29", 대한피부과학회지, 42(1), pp.9~15 (2004), 대한피부과학회
  13. Park MC, "A literature study about the comparison of oriental occidental medicine on the atopic dermatitis", Journal of Korean Oriental Medical Ophthalmology & Otolaryngology &Dermatology, 15(1), pp.226~252 (2002)
  14. Ministry of Food and Drug Safety, "The clinical trial guidelines of herbal medicine drug : Atopic dermatitis" (2009), Biopharmaceuticals and Herbal Medicine Bureau
  15. Yun HJ, "Clinical Study of Atopic Dermatitis; the Classification of Oriental Medical Clinical type and Treatment", J Korean Oriental Med, 22(2), pp.10~21 (2001)
  16. Leung DYM, "Atopic dermatitis: new insights and opportunities for therapeutic intervention", J. Allergy Clin. Immunol, 105, pp.860~876 (2000)
  17. Schultz Larsen F, "Secular change in the occurrence of atopic dermatitis", Acta Derm Venereol Suppl, 176, pp.7~12 (1992)
  18. Ogawa H, "A speculative view of atopic dermatitis : barrier dysfunction in pathogenesis", J Dermatol Sci, 5, pp.197~204 (1993)
  19. Imokawa G, "Decreased level of ceramides in stratum corneum of atopic dermatitis : an etiologic factor in atopic dry skin?", J Invest Dermatol, 96(4), pp.523~526 (1991)
  20. Horikawa T, "An open clinical trial of glycoceramide-containing cream and lotion on dry skin of atopic dermatitis", Hifu, 40(4), pp.415~419 (1998)
  21. 정승일, "천연물 유래 Th2 케모카인 억제제 발굴에 의한 새로운 아토피 피부염 치료기술 개발 : 아토피 피부염 모델 NC", Nga 마우스에서 고삼 추출액의 억제 효과, 2009, pp.17(1), 141~151[DOI]
  22. 송다해, "집먼지 진드기 (Dermatophagoides farinae)로 유발된 NC", Nga mice의 아토피피부염에 대한 고삼 (Sophra flavescens radix) 에탄올추출물 크림의 효능연구, 2009, pp.15(4), 1243~1252[DOI]
  23. 강신정, "한방소재 화장품의 아토피 피부염 개선 효과", 한국산학기술학회논문지, 10(11), pp.3500~3505 (2009), 한국산학기술학회
  24. Ahn DK, "Illustrate Book Of Korean Medicinal Herbs", pp.34~ (1998), Kyohak Publishing
  25. Bor-Sen Wang, "Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq", Food and Chemical Toxicology, 50, pp.526~531 (2012)
  26. Jin-Su Yoo, "Anti-allergic Effects of Schizonepeta tenuifolia on Mast Cell-Mediated Allergy Model", Natural Product Sciences, 17(3), pp.239~244 (2011), 한국생약학회
  27. Cho SI, "Regulatory mechanism of Schizonepeta tenuifolia Briquet on HMC-1 mast cells :microarray analysis", pp.2009
  28. 임대환, "東醫寶鑑 中 荊芥가 主藥으로 配伍된 方劑의 活用에 대한 考察", 대한한의학 방제학회지, 17(2), pp.21~38 (2009), 대한한의학방제학회
  29. 김승훈, "玄蔘, 白茯？, 金銀花, 馬齒？, 白果葉을 함유하는 한방화장품이 인체 피부의 보습 및 청열 효능에 미치는 영향", 대한본초학회지, 22(2), pp.45~50 (2007), 대한본초학회
  30. Schmitt J, "What are the best outcome measurements for atopic eczema? A systematic review", J Allergy Clin Immunol, 120(6), pp.1389~1398 (2007)
  31. Finlay AY, "Quality of life in atopic dermatitis", J Am Acad Dermatol, 45, pp.S64~S66 (2001)
  32. Lewis-Jones S, "Quality of life and childhood atopic dermatitis : the misery of living with childhood eczema", Int J Clin Pract, 60, pp.984~992 (2006)
  33. 김민희, "한국어판 skindex-29를 통해 본 피부과 환자의 삶의 질", 대한한의학회지, 26(3), pp.43~54 (2005), 대한한의학회
  34. Chren MM, "Skindex, a quality-of-life instrument for patients with skin disease", Arch Dermatol, 133, pp.1433~1440 (1997)

관련 논문AI추천

아토피 피부염에 대한 樺皮, 蔓荊子, 仙鶴草 함유 외용제의 임상 효과정현아, 홍지희대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2014 · 제27권 제1호한국의 아토피피부염 환자에서 혼합생약추출물 함유 로션의 효능에 대한 예비연구김기호, 김명남, 김민영, 김범준, 김영희, 김형미, 석장미, 손인평, 임윤영대한천식알레르기학회 · 천식 및 알레르기2012 · 제32권 제1호경증의 아토피 환자에서 한약 추출물 함유외용제에 대한 임상 연구강민서, 김정범, 김희택대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2014 · 제27권 제3호삼황세제 가미방 화장품의 아토피 피부염 환자에 대한 임상적 연구박민철, 배현진, 백상철, 양현주, 정수영, 조정희, 조현우, 주현아, 홍석훈, 황충연대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2012 · 제25권 제3호아토피 피부염 증례 연구 분석 -한약 처방을 중심으로-강동원, 김규석, 김봉현, 김윤범, 박소영, 박중군, 한창이대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2019 · 제32권 제3호선태, 백지 외 10종 한약재 추출물 함유 외용한약의아토피 피부염 치료효과에 대한 후향적 연구박규정, 신상호, 윤영희, 이은지, 조현정, 최연길, 최예용대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2018 · 제31권 제2호

이 간행물의 다른 논문 (11건)

아토피 피부염에 대한 樺皮, 蔓荊子, 仙鶴草 함유 외용제의 임상 효과정현아, 홍지희pp. 1-16아토피 환자의 치료선택 경향에 대한 설문연구손창규pp. 37-44노화와 피부노화에 대한 동서의학적 고찰윤화정, 고우신, 한정민pp. 45-57구기자 추출물이 피부 미백 및 주름에 미치는 영향박수연, 김종한, 최정화, 정민영, 최주호pp. 58-67백선피(Dictamnus dasycarpus Turcz) 추출물의 급성 경구투여 독성 연구정자영, 석지현, 하헌용, 노항식pp. 68-78
원문 보기