본문 바로가기
KERD
논문KCI 등재

아토피 피부염 환자에서 黃連解毒湯이 함유된 한방화장품에 대한 임상 연구

Clinical Research of Atopic Dermatitis Treated by Hwangryeonhaedok-Tang in Cosmetics

김희택|김이화|호동수|윤대철
한의병리학회 (The Society of Pathology in Korean Medicine)|2008.12|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제22권 제6호|pp. 1611-1620

2

조회

0

다운로드

12

인용

0

참고문헌

키워드

atopic dermatitisTEWLskin temperaturecosmeticsexternal applicationskin hydrationskin pHHwangryeonhaedok-Tangtotal IgEeosinophil count
주제분류한의학

초록

This clinical research was conducted to test patients with Atopic Dermatitis by external application with Hwangryeonhaedok-Tang in cosmetics. We gave scores to 31 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung University Jecheon Oriental Medical Hospital from May 15th, 2008 to June 26th. Fifteen patients were treated with the ointment that contain Hwangryeonhaedok-Tang (experimental group) and sixteen patients were treated with normal ointment that doesn't have Hwangryeonhaedok-Tang (control group) for 4 weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinical Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Hwangryeonhaedok-Tang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). After 4 weeks of external application treatment, SCORAD Index in experimental group was significant statistically decreased compared with control group. After 4 weeks of external application treatment, total IgE of both groups were decreased and eosinophil count in control group was decreased but experimental group was unstatistically decreased. Unstatistically, both groups didn't showed significant effect on Skin Temperature. Transepidermal Water Loss(TEWL) in both groups were increased but experimental group was significant decreased compared with control group. Skin Hydration in experimental group was significant statistically increased compared with control group. Statistically, both groups didn't showed significant effect on Skin pH. Only experimental group showed little increase. After 4 weeks of external application treatment, experimental group showed significant effect on global assesment of efficacy. Considering the above results, we can speculate that cosmetics with Hwangryeonhaedok-Tang has some therapeutical effects in mitigating the symptoms of Atopic Dermatitis.

Abstract

This clinical research was conducted to test patients with Atopic Dermatitis by external application with Hwangryeonhaedok-Tang in cosmetics. We gave scores to 31 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung University Jecheon Oriental Medical Hospital from May 15th, 2008 to June 26th. Fifteen patients were treated with the ointment that contain Hwangryeonhaedok-Tang (experimental group) and sixteen patients were treated with normal ointment that doesn't have Hwangryeonhaedok-Tang (control group) for 4 weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinical Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Hwangryeonhaedok-Tang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). After 4 weeks of external application treatment, SCORAD Index in experimental group was significant statistically decreased compared with control group. After 4 weeks of external application treatment, total IgE of both groups were decreased and eosinophil count in control group was decreased but experimental group was unstatistically decreased. Unstatistically, both groups didn't showed significant effect on Skin Temperature. Transepidermal Water Loss(TEWL) in both groups were increased but experimental group was significant decreased compared with control group. Skin Hydration in experimental group was significant statistically increased compared with control group. Statistically, both groups didn't showed significant effect on Skin pH. Only experimental group showed little increase. After 4 weeks of external application treatment, experimental group showed significant effect on global assesment of efficacy. Considering the above results, we can speculate that cosmetics with Hwangryeonhaedok-Tang has some therapeutical effects in mitigating the symptoms of Atopic Dermatitis.

참고문헌 (40)

  1. Shultz, L.F., "Epidemiology of atopic dermatitis", Immunol Allergy Clin North AM, 22, pp.1~24 (2002)
  2. Oh, J.W., "Nationwide study for epidemiological changes of atopic dermatitis in school aged children between 1995 and 2000 and kindergarten aged children in 2003 in Korea", Pediatr Allergy Resir Dis, 13(4), pp.227~237 (2003)
  3. Bos, J.D., "Immuune dysregulation in atopic eczema", Arch Dermatol, 128, pp.1509~1512 (1992)
  4. Taieb, A., "Hypothesis: from epidermal barrier dysfunction to atopic disorders", Contact Dermatitis, 41, pp.177~180 (1999)
  5. 안석용, "아토피피부염과 피부장벽", 한국피부장벽학회지, 8(1), pp.47~51 (2006)
  6. Ogawa, H., "A speculative view of atopic dermatitis: barrier dysfunction in pathogenesis", J Dermatol Sci, 5, pp.197~204 (1993)
  7. 윤상웅, "녹차추출물을 함유한 보습제의 항염증 효과 평가", 대한피부과학회지, 41(1), pp.15~20 (2003), 대한피부과학회
  8. Bohme, M., "Clinical features of atopic dermatitis at two years of age. A prospective, population-based case-control study", Acta Derm Venerol, 81, pp.193~197 (2001)
  9. 박영립, "아토피피부염 학회보고서: 한국인 아토피피부염의 진단기준에 대한 연구", 대한피부과학회지, 44(6), pp.659~663 (2006), 대한피부과학회
  10. Kim, K.H., "Periauricular eczematization in chilldhood atopic dermatitis", Ped Dermatol, 14, pp.278~280 (1996)
  11. Kanwar, A.J., "Evaluation of minor clinical features of atopic dermatitis", Ped Dermatol, 8, pp.114~116 (1991)
  12. Sevensson, A., "A diagnostic tool for atopic dermatitis based on clinical criteria", Acta Derm Venereol (Stockh), 114, pp.33~40 (1985)
  13. Moller, H., "Clinical aspects of atopic dermatitis in children", Acta Derm Venereol (Stockh), 95, pp.25~28 (1981)
  14. 대한피부과학회 교과서 편찬위원회, "피부과학 제5판", pp.170~178 (2008), 여문각, 서울
  15. Eigenmann, P.A., "Clinical features and diagnostic criteria of atopic dermatitis in relation to age", Pediatr Allergy Immunol, 12, pp.69~74 (2001)
  16. Park, Y.M., "The study on the hospital-based relative frequency, and clinical and laboratory findings of atopic dermatitis", Korean J Dermatol, 35, pp.96~106 (1997)
  17. 이지현, "아토피피부염학회 보고서: 한국 아토피피부염의 치료지침", 대한피부과학회지, 44(8), pp.907~913 (2006), 대한피부과학회
  18. 박영립, "아토피피부염에서 보습제 사용", 한국피부장벽학회지, 19(1), pp.37~40 (2007)
  19. 최인화, "아토피 피부염에 관한 임상적 연구", 대한한의사협회지, 12(1), pp.73~83 (1991)
  20. Hill, C.J., "Adverse effects from topical steroids", Cutis, 21, pp.624~628 (1978)
  21. Ruiz-Maldonado, R., "Cushing's syndrome after topical application of corticosteroids", Am J Dis Child, 136, pp.274~275 (1982)
  22. McLean, C.J., "Cataracts glaucoma, and femoral avascular necrosis caused by topical corticosteroids ointment", Lancet, 345, pp.330~330 (1995)
  23. Bode, H.H., "Dwarfism following long-term topical corticosteroid therapy", JAMA, 244, pp.813~814 (1980)
  24. Queille, C., "Efficacy versus systemic effect of six topical steroids in the treatment of atopic dermatitis of childhood", Pediatr Dermatol, 1, pp.246~253 (1984)
  25. 이희정, "성인 아토피피부염 환자에서 삶의 질 평가의 임상적 유용성", 대한피부과학회지, 45(2), pp.159~164 (2007), 대한피부과학회
  26. 신나라, "소아기 아토피 피부염이 가족에 미치는 영향에 관한 연구", 대한피부과학회지, 38(4), pp.494~499 (2000)
  27. 양수진, "소아에서 아토피 피부염의 중증도와 정신, 행동 및 가족문제의 관련성", 대한피부과학회지, 43(9), pp.1170~1176 (2005), 대한피부과학회
  28. 공남미, "아토피 피부염의 양 한방적 고찰", 대한외관과학회지, 12, pp.241~253 (1999)
  29. 朴志修, "아토피 환자의 식이요법 및 외용요법의 조사와 체질별 적용", 대한한방소아과학회지, 17(2), pp.85~101 (2003)
  30. 장은영, "소아 아토피피부염에서의 대체보완요법 이용에 관한 연구", 천식 및 알레르기, 25(2), pp.110~116 (2005), 대한알레르기학회
  31. 김창훈, "아토피 피부염 환자에서 한방 추출물이 포함된 외용제품에 대한 임상 효과", 한방안이비인후피부과학회지, 20(2), pp.187~198 (2007), 대한한방안이비인후피부과학회
  32. 황순이, "아토피 피부염 환자에서 七葉膽을 함유한 화장품의 임상적 연구", 한방안이비인후피부과학회지, 20(3), pp.212~221 (2007), 대한한방안이비인후피부과학회
  33. 葛仙翁, "肘後備急方", pp.3~9 (1978), 集文書局, 臺北
  34. 王燾, "外臺秘要", pp.72~72 (1968), 國立中國醫藥硏究所, 臺北
  35. 이인수, "黃連解毒湯의 사람 비점막 섬유아세포 IL-8 분비에 대한 효과", 대한안이비인후피부과학회지, 16(3), pp.68~81 (2003)
  36. 최유성, "아토피피부염의 중증도에 따른 임상 및 검사실 소견에 관한 연구", 대한피부과학회지, 44(7), pp.824~829 (2006), 대한피부과학회
  37. 김명남, "아토피 피부염에서 말초 혈액내 호산구 수, 혈청 총 IgE, eosinophil cationic protein, IL-4 및 soluble E-selectin의 변화", 대한피부과학회지, 40(11), pp.1367~1373 (2002), 대한피부과학회
  38. Kim, D.W., "Correlation of clinical features and skin barrier function in adolescent and adult patients with atopic dermatitis", Int J Dermatol, 45(6), pp.698~701 (2006)
  39. 장윤환, "Tape Stripping에 의한 각질층 제거 정도에 따른 피부장벽기능의 변화", 대한피부과학회지, 43(7), pp.919~925 (2005), 대한피부과학회
  40. 소병화, "피부효과의 기기평가", 한국 피부장벽학회지, 8(1), pp.68~75 (2006)

관련 논문AI추천

連翹升麻湯이 함유된 한방화장품이 아토피 피부염에 미치는 임상 연구김성호, 김희택, 윤경섭, 윤대철, 호동수대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2008 · 제21권 제2호托裏消毒飮 함유 외용제의 아토피 피부염에 대한 임상적 연구김희택, 오민지, 유영법, 임신혁대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2011 · 제24권 제3호삼황세제 가미방 화장품의 아토피 피부염 환자에 대한 임상적 연구박민철, 배현진, 백상철, 양현주, 정수영, 조정희, 조현우, 주현아, 홍석훈, 황충연대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2012 · 제25권 제3호黃連解毒湯이 아토피 피부염에 미치는 영향에 대한 임상적 연구고민정, 백정한대한한방소아과학회 · 대한한방소아과학회지2012 · 제26권 제4호경증의 아토피 환자에서 한약 추출물 함유외용제에 대한 임상 연구강민서, 김정범, 김희택대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2014 · 제27권 제3호아토피 피부염 환자에서 상황버섯 추출물을 함유한 한방화장품의 임상적 연구김미려, 김영훈, 도국배, 도은주, 석장미, 이창언, 정호준, 지선영, 황보민대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2010 · 제23권 제3호

이 간행물의 다른 논문 (28건)

金元四大家의 黃疸에 대한 문헌적 고찰송정호, 윤혁, 정헌영, 김강산, 나민수, 김병민, 김수성, 유금해pp. 1331-1346歷代醫家의 脈象 分類에 대한 연구강정수, 박재원, 김병수pp. 1347-1353사상체질과 한열의 관점에서 본 성격과 소증의 연관성 연구김종열, 이혜정, 진희정, 김명근, 유종향pp. 1354-1358한방진단시스템과 진단의 간의 진단일치도 연구김종원, 이용태, 지규용, 김규곤, 이인선pp. 1359-1367河圖 원리로 본 四肢關節의 五行배속 연구김병수pp. 1374-1377
원문 보기