점프 트레이닝이 난소적출 쥐의 골 재형성에 미치는 영향
To examine the effects of jump training on bone remodeling in OVX rats
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권기욱, 김영주, 김호성, 신영오, 정희정, 이정필, 오재근. 점프 트레이닝이 난소적출 쥐의 골 재형성에 미치는 영향. 운동과학, 제14권 제2호, 143-152, 2005. 점프 트레이닝이 난소적출 쥐의 골 재형성에 미치는 영향을 조사하였다. 6주령된 SD계 암컷 흰쥐 56마리를 이용하여 난소적출과 가장수술을 실시하였다. 수술된 쥐들은 다음과 같이 네 그룹으로 나누었다. 가장수술 대조군(Sham-Cont; n=14), 가장수술 운동군(Sham-Exc; n=14), 난소적출 대조군(OVX-Cont; n=14), 그리고 난소적출 운동군(OVX-Exc; n= 14). 점프 트레이닝은 쥐의 체중에는 영향을 미치지 않았으나, 난소적출군은 가장수술 군보다 체중이 유의하게 증가하였다(p<0.001). 난소적출 운동군은 조직학적 검사에서 난소적출 대조군보다 소주골 너비와 수가 증가하였다. 그러나 가장수술군보다는 소주골 너비와 수가 적었다. 4주, 8주 모두에서 가장수술 대조군보다 난소적출 대조군이 OPG 발현수준이 더 감소하였다. 점프 트레이닝은 난소적출군에서 OPG 발현수준을 증가시켰으나 가장수술군에서는 변화가 없었다. 또한, 난소적출 운동군의 OPG 발현수준은 가장수술군의 변화만큼 증가하였다. 점프 트레이닝은 가장수술군과 난소적출군 모두에서 RANKL 발현수준에는 영향을 미치지 않았다. 가장수술군에서 점프 트레이닝은 OPG/ RANKL ratio에 영향을 주지 못했으나, 난소적출군에서는 OPG/RANKL ratio에 증가를 나타내었다. 그러므로 본 연구에서는 난소적출 한 쥐에서 점프트레이닝이 조직학 검사와 OPG 단백질 발현수준에 긍정적인 영향을 나타내었다.
Abstract
Kwon, K.W., Kim, Y.J., Kim, H.S., Jung, H.J., Lee, J.P., Oh, J.K. To examine the effects of jump training on bone remodeling in OVX rats. Exercise Science, 14(2): 143-152, 2005. To examine the effects of jump training on bone remodeling in OVX rats, fifty six female Sprague-Dawley rats were sham-operated (Sham) and ovariectomized (OVX) at the age of six weeks. The rats were divided randomly into the following four groups: sham-control (Sham-Cont; n=14), sham-exercise (Sham-Exc; n=14), OVX-control (OVX-Cont; n=14), and OVX-exercise (OVX-Exc; n=14). Jump training was no significant change in body weight. However, the final body weights of the OVX groups significantly increased compared to the Sham groups(p<.001). Histology in OVX-Exc showed increase in width and number of trabecular bone compared to OVX-Cont but they were somewhat smaller than the Sham groups. The OPG protein expression level was decreased after four weeks and eight weeks in OVX-Cont, compared to Sham-Cont. Jump training was increased the OPG protein expression level in OVX groups. The OPG protein expression level after jump training did not changes in the Sham groups. Also the OPG protein expression level in OVX-Exc was increased as much as in the Sham groups. Jump training did not affect the RANKL protein expression level in both the Sham groups and OVX groups. In the Sham groups, jump training did not affect OPG/RANKL ratio, but in the OVX groups, jump training did affect the increase of OPG/RANKL ratio. Therefore, in jump training, histology indicated that there were beneficial effects on bone and that OPG protein expression levels were affected by jump training.
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