진동운동이 난소절제술을 시행한 흰쥐의 골다공증 예방에 미치는 효과
The Effect of Whole-Body Vibration Exercise on Prevent of Osteoporosis in Ovariectomized Rats
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정희정, 권기욱, 오재근. 진동운동이 난소절제술을 시행한 흰쥐의 골다공증 예방에 미치는 효과. 운동과학, 제16권 제3호. 263-270, 2007. 이 연구의 목적은 전신진동운동이 골 소실 억제와 골다공증 예방효과에 미치는 영향을 살펴보는데 그 목적이 있다. 이를 위해 SD rats를 대상으로 12주 동안 진동운동(45Hz, 0.3g, 주 5일, 12주)을 수행시켰다. 그리고 골밀도 측정(DXA) 및 혈중 IGF-I과 PTH(ELISA), 그리고 칼슘(비색법)을 분석하여 집단(sham-c, ovx-c, ovx-e)간 운동 전·후(o주, 12주)간에 변인들의 변화를 살펴보았다. 실험을 통해 나온 모든 자료는 평균과 표준편차로 산출하였다. 집단과 운동 전·후에 따른 변인의 비교는 two-way ANOVA를 이용하였으며, 집단별 기간에 따른 변인의 비교는 repeated one-way ANOVA를 사용하였다. 사후검정을 위해 Bonferroni 테스트를 실시하였으며, 통계적 유의수준은 p<.05로 설정하였다. 본 실험 결과 진동운동 수행은 골밀도와 PTH 그리고 ionized calcium 수준에 통계적으로 유의한 효과를 나타내었다(p<.05). 그러나 혈중 IGF-I은 진동운동 수행에 따른 유의한 차이를 보이지 않았다. 이상의 연구결과를 종합해 볼 때, 진동 운동은 폐경여성의 골 소실 억제와 골 건강 증진을 위한 운동으로써 긍정적 가치가 있다고 사료된다.
Abstract
Jung H.J., Kwon K.W., Oh J.K. The Effect of Whole-Body Vibration Exercise on Prevent of Osteoporosis in Ovariectomized Rats. Exercise Science, 16(3): 263-270, 2007. The purpose of this study was to investigate potential possibility for activation of bone formation and decrease of bone loss while whole-body vibration exercise(WBV) was performed at a intensity (frequency 45Hz, vertical acceleration 0.3g) and a duration (5days/wk for 12wks) on the vibrating plate. The SD rats were divided into 3 groups(sham-operated control; ovx-operated control; ovx-operated WBV exercise). We assayed the serum IGF-I, PTH, and ionized calcium and measured the BMD of femur bone. All values were expressed as means±SD. Data were assessed by two-way ANOVA and one-way ANOVA with repeated measurements. The difference between the experimental groups was assessed by Bonferroni. Statistical significance was set at p<.05. As a result, ovx-e groups's BMD, PTH and ionized calcium concentration values were higher than control group significantly, but serum IGF-I value was not different between ovx-e and ovx-c group. Analysis of data suggested a conclusion that WBV exercise is effective method for preventing bone loss and improving bone health for post-menopausal women.
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