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저항성 운동이 성장기 흰쥐의 골밀도 및 골강도에 미치는 영향

Effects of resistance exercise training on bone mineral density and mechanical strength in growing male rats

이기철|김형렬|권태동|이상직
한국운동생리학회|2004.02|운동과학 (Exercise Science)|제13권 제1호|pp. 1-14

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참고문헌

키워드

DEXA동물모델웨이트리프팅 트레이닝하지골최대골절력weight-lifting traininghindlimb bonemaximum breaking forceanimal model.

초록

본 실험에서는 흰쥐의 대퇴골 및 경골 골밀도 및 골강도에 미치는 저항성운동(resistance exercise)의 효과를 연구하기 위하여 8주령된 SD계 수컷흰쥐 21마리를 resistance(RT), sham(Sham), 그리고 sedentary(Sed)의 3집단으로 나누었다. 이 실험의 운동방법은 인간의 스쿼트운동과 유사한 동물용 resistance 운동기구를 개발하여 흰쥐에 부하하였다. 운동프로그램은 1일 45～50분 동안 1RM의 65～75% 스쿼터운동을 주 3～4일 동안 부하하였고 과부하의 원리에 의해 무게를 점진적으로 증가시키는 방법으로 구성되었다. 그 결과, 경골의 건조중량은 RT집단이 Sed집단에 비해서 각각 10%, 24% 정도 높았다. 또한 경골의 골밀도는 7% 증가하였다. RT집단의 대퇴골경부 및 골간의 골밀도는 다른2집단과 비교하여 유의하게 높았다. 그리고 대퇴골경부 (r = 0.59, p < 0.01) 및 골간(r = 0.54, p < 0.02)에서 골강도(maximum breaking force)와 골밀도 사이에 유의한 상관관계를 나타내었다. 이러한 결과는 저항성운동이 성장기 흰쥐의 하지골밀도를 증가시키며 그에 따른 골강도도 강화시킨다는 것을 시사하고 있다. 따라서 본 연구에 이용된 운동프로그램은 앞으로 운동과 골대사에 관한 연구에 많이 이용되리라 사료된다.

Abstract

Lee, S.J., Kim, H.R., Lee, K.C., Kwon, T.D. Effects of resistance exercise training on bone mineral density and mechanical strength in growing male rats. Exercise Science, 13(1): 1-14, 2004. Effects of resistance exercise training on bone mineral density and mechanical strength in growing male rats. Twenty-one male Sprague-Dawley rats, eight week of age, were assigned randomly to resistance training, sham training, and to a sedentary groups to study the effects of resistance exercise on bone mineral density (BMD) and mechanical strength of the hindlimb bone. A new resistance training apparatus that induces rats to perform motions analogous to human resistance training was designed for this study. Resistance training consisted of squatting at 65～75% of one repetition maximum (1RM) for 45～50 min/day and 3～4 days/week with a progressively increased load. After 12 week of training, the total muscle and the tibia dry weight/body weight were 10% and 24% heavier, respectively, than those of the sedentary rats. Similarly, the tibia bone diameter was 7% greater. A significantly increased femoral neck and midshaft BMD was observed in the resistance tained rats compared with the other groups. The correlation coefficient between maximum breaking force and BMD revealed positive relationships in the femoral neck (r=0.59, p < 0.01) and midshaft (r=0.54, p < 0.02). These results indicate that resistance exercise training enhances the mechanical strength by increasing bone mass of a growing rat.

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