중심각막두께 측정에 대한 파장가변 빛간섭단층촬영계의 유용성
Utility of the Swept Source Optical Coherence Tomography for Measurements of Central Corneal Thickness
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목적: 파장가변 빛간섭단층촬영계(swept source optical coherence tomography, SS-OCT)로 측정한 중심각막두께를 초음파 각막두께측정계(ultrasound pachymetry), Orbscan II, 전안부 빛간섭단층촬영계(anterior segment optical coherence tomography, AS-OCT) 로 측정한 중심각막두께와 비교하여 SS-OCT의 임상적 일치율의 유용성을 알아보고자 하였다. 대상과 방법: 한 명의 검사자가 65명 65안의 정상안을 대상으로 Orbscan II, AS-OCT, SS-OCT, 초음파 각막두께측정계의 순서로 중심각막두께를 측정하여 상관관계를 비교, 분석하였다. 결과: Orbscan II, AS-OCT, SS-OCT와 초음파 각막두께측정계를 이용하여 측정한 각각의 평균 중심각막두께는 각각 534.83 ± 38.46, 517.80 ± 32.48, 528.22 ± 33.71, 528.02 ± 34.90 μm였다. 4가지 검사기기에서 높은 상관관계를 보였으며(r>0.894, p<0.001 in all groups), SS-OCT와 초음파 각막두께측정계를 이용한 측정치에서 통계적으로 유의한 일치율을 보였다(p=0.782). 결론: 정상인에서 SS-OCT로 측정한 중심각막두께가 초음파 각막두께측정계로 측정한 값에 높은 일치율을 보여, 정상인의 중심각막두께 측정에 SS-OCT가 초음파 각막두께측정계를 대체할 수 있는 유용한 방법이라 생각된다.
Abstract
Purpose: To evaluate the efficacy of swept source optical coherence tomography (SS-OCT) by comparing the measurement of central corneal thickness (CCT) to the measurement obtained using Orbscan II, anterior segment optical coherence tomography (AS-OCT) and ultrasound pachymetry. Methods: One examiner measured the CCT in 65 eyes of 65 healthy subjects using Orbscan II, AS-OCT, SS-OCT and ultrasound pachymetry. The mean values and correlations were analyzed. Results: The average CCT measurements obtained using Orbscan II, AS-OCT, SS-OCT and ultrasound pachymetry were 534.83 ± 38.46, 517.80 ± 32.48, 528.22 ± 33.71 and 528.02 ± 34.90 μm, respectively. A significant linear correlation was observed among Orbscan II, AS-OCT, SS-OCT and ultrasound pachymetry (r > 0.894, p < 0.001). There was no significant difference between the SS-OCT and ultrasound pachymetry (p = 0.782). Conclusions: The results of the 4 methods were significantly correlated and the SS-OCT reached a high level of agreement when CCT was determined using ultrasound pachymetry. The CCT measurements using SS-OCT is a better alternative for ultrasound pachymetry than Orbscan II and AS-OCT.
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