건강한 성인의 유산소 운동강도에 따른 장내미생물 구성요인 변화(변화추이 분석)
Changes in the Composition of Gut Microbiome according to the Intensity of Aerobic Exercises in Healthy Adults
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초록
이 연구는 4주간의 운동강도별 유산소 운동을 수행한 후, 장내미생물의 Phylum 구성요인 변화를 분석하였 다. 총 24명의 남성들이 참여하였으며, 비운동군(Non Exercise Group, NEG, 28.6 ± 5.3 yrs, 176.0 ± 7.8 cm, 81.3 ± 14.6 kg), 중강도 운동군(Moderate Intensity Exercise Group, MIEG, 26.5 ± 3.3 yrs, 176.9 ± 5.0 cm, 75.4 ± 9.5 kg), 고강도 운동군(Vigorous Intensity Exercise Group, VIEG, 30.6 ± 5.9 yrs, 174.2 ± 3.5 cm, 77.8 ± 12.2 kg)으로 구분하였다. 대상자 선정을 위한 절차로 신체활동과 장건강 상태, 질환 보유 여부, 최근 질병 진단 여부 및 식이장애 여부를 확인하였다. 장내 마이크로바이옴 분석을 위해 10시간 공복 후에 채변하였다. MIEG는 개인의 %VO2R 40%-59%, 주 3회, 하루에 50분 이상, 주 150분 이상 중강도 유산소 운동을 진행하였고, VIEG는 %VO2R 60% 이상의 강도로 주 3회, 5분 간의 준비운동을 포함하여 하루에 30분 이상, 주 90분 이상으로 고강도 유산소 운동을 수행하였다. 4주 훈련 뒤에 모든 연구 대상자들은 장내마이크로바이옴 채변을 수집하였다. 데이터 분석은 Kruskal-Wallis, Wilcoxon 검증을 실시하였다. 연구 결과, 그룹간 변화에서 Actinobacteria에서 유의한 차이가 나타났다( <0.05). 중강도 운동군은 Firmicutes가 감소하였고( <0.05), 고강도 운동군에서는 Bacteroidetes가 증가하고, Firmicutes와 F/B ratio는 감소하였다 ( <0.05). 운동 수행만으로 장내미생물의 구성요인이 변화될 수 있음을 확인하였다.
Abstract
This study analyzed changes in the phylum component of intestinal microbes after performing aerobic exercise by exercise intensity for 4 weeks. A total of 24 men volunteered for the study and they were evenly divided into three groups; Non-Exercise Group (NEG, 28.6±5.3 yrs, 176.0±7.8 cm, 81.3±14.6 kg), Moderate Intensity Exercise Group (MIEG, 26.5±3.3 yrs, 176.9±5.0 cm, 75.4±9.5 kg) and Vigorous Intensity Exercise Group (VIEG, 30.6±5.9 yrs, 174.2±3.5 cm, 77.8±12.2 kg). For the inclusion in the study, their physical activity level, intestinal health status, disease prevalence, medical history, and eating disorder were assessed. The basal level of gut microbiome in all participants was examined by stools collected one morning after a 10-hour fasting. Those in MIEG exercised aerobically at 40-50% of VO2max for 50 min a day, 3 times a week matching 150 min per week. Those in VIEG exercised aerobically at over 60% of VO2max for over 30 min a day including warm-up, 3 times a week matching more than 90 min per week. After 4 weeks of training in MIEG and VIEG, samples of gut microbiome were collected. Data analysis was performed using Kruskal-Wallis and Wilcoxon. As a result, significant difference in Actinobacteria in the change between groups (p<0.05). Firmicutes decreased in the MIEG (p<0.05). Bacteroidetes increased, Firmicutes and F/B ratio decreased in the HIEG (p<0.05). It was confirmed that the constituent factors of the gut microbiome can be changed only by performing exercise.
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