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운동과 장내 미생물: 연구방법의 발전과 연구동향

Exercise and Gut Microbiome: Trends and Advances in Research Methods

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초록

PURPOSE: To suggest future research directions and current research trends based on representative studies of existing exercises and the gut microbiome. In addition, we reviewed methodologies to study the relationship between exercise and the gut microbiome. METHODS: The research methodologies and results were integrated through a literature review of the latest “exercise and gut microbiome” studies and a narrative review. RESULTS: Although exercise is indirectly related to the gut microbiome or immunity, evidence for a direct effect is still lacking. However, with the recent discovery of gut microbiomes that can help improve exercise performance, it is clear that exercise can positively alter the gut microbiome. CONCLUSIONS: Strong evidence suggests that regular moderate exercise improves overall immune function and lowers the incidence of inflammation-related disease. In addition, certain microorganisms affect exercise performance

Abstract

PURPOSE: To suggest future research directions and current research trends based on representative studies of existing exercises and the gut microbiome. In addition, we reviewed methodologies to study the relationship between exercise and the gut microbiome. METHODS: The research methodologies and results were integrated through a literature review of the latest “exercise and gut microbiome” studies and a narrative review. RESULTS: Although exercise is indirectly related to the gut microbiome or immunity, evidence for a direct effect is still lacking. However, with the recent discovery of gut microbiomes that can help improve exercise performance, it is clear that exercise can positively alter the gut microbiome. CONCLUSIONS: Strong evidence suggests that regular moderate exercise improves overall immune function and lowers the incidence of inflammation-related disease. In addition, certain microorganisms affect exercise performance

참고문헌 (53)

  1. Campbell SC, "Exercise is a novel promoter of intestinal health and microbial diversity", Exerc Sport Sci Rev, 45(1), pp.41~47 (2017)
  2. Hooper LV, "Commensal host-bacterial relationships in the gut", Science, 292(5519), pp.1115~1118 (2001)
  3. Iebba V, "Eubiosis and dysbiosis : the two sides of the microbiota", New Microbiol, 39(1), pp.1~12 (2016)
  4. Henao-Mejia J, "Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity", Nature, 482(7384), pp.179~185 (2012)
  5. Navab-Moghadam F, "The association of type II diabetes with gut microbiota composition", Microb Pathog, 110, pp.630~636 (2017)
  6. Kostic AD, "The microbiome in inflammatory bowel disease : current status and the future ahead", Gastroenterology, 146(6), pp.1489~1499 (2014)
  7. Bhutia YD, "Gut microbiome and colon cancer : role of bacterial metabolites and their molecular targets in the host", Curr Colorectal Cancer Rep, 13(2), pp.111~118 (2017)
  8. Yap CX, "Autism-related dietary preferences mediate autism-gut microbiome associations", Cell, 184(24), pp.5916~5931 (2021)
  9. Walsh NP, "Position statement. Part one: immune function and exercise", Exerc Immunol Rev, 17, pp.6~63 (2011)
  10. Walsh NP, "Position statement. Part two: maintaining immune health", Exerc Immunol Rev, 17, pp.64~103 (2011)
  11. Campbell JP, "Debunking the myth of exercise-induced immune suppression : redefining the impact of exercise on immunological health across the lifespan", Front Immunol, 9, pp.648~ (2018)
  12. Baek KW, "Exercise training reduces the risk of opportunistic infections after acute exercise and improves cytokine antigen recognition", Pflugers Arch, 472(2), pp.235~244 (2020)
  13. Zhu W, "Should, and how can, exercise be done during a coronavirus outbreak? an interview with Dr. Jeffrey A. Woods", J Sport Health Sci, 9(2), pp.105~107 (2020)
  14. Rappe MS, "The uncultured microbial majority", Annu Rev Microbiol, 57, pp.369~394 (2003)
  15. Wheeler DA, "The complete genome of an individual by massively parallel DNA sequencing", Nature, 452(7189), pp.872~876 (2008)
  16. Wooley JC, "A primer on metagenomics", PLoS Comput Biol, 6(2), pp.e1000667~ (2010)
  17. Hamady M, "Microbial community profiling for human microbiome projects : Tools, techniques, and challenges", Genome Res, 19(7), pp.1141~1152 (2009)
  18. Boers SA, "Understanding and overcoming the pitfalls and biases of next-generation sequencing(NGS)methods for use in the routine clinical microbiological diagnostic laboratory", Eur J Clin Microbiol Infect Dis, 38(6), pp.1059~1070 (2019)
  19. DeSantis TZ, "Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB", Appl Environ Microbiol, 72(7), pp.5069~5072 (2006)
  20. Quast C, "The SILVA ribosomal RNA gene database project: improved data processing and web-based tools", Nucleic Acids Res, 41, pp.D590~D596 (2013)
  21. Cole JR, "Ribosomal database project: data and tools for high throughput rRNA analysis", Nucleic Acids Res, 42, pp.D633~D642 (2014)
  22. Jeong J, "The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology", Sci Rep, 11(1), pp.1727~ (2021)
  23. Manichanh C, "Reduced diversity of faecal microbiota in crohn's disease revealed by a metagenomic approach", Gut, 55(2), pp.205~211 (2006)
  24. Shakya M, "Advances and challenges in metatranscriptomic analysis", Front Genet, 10, pp.904~ (2019)
  25. Schirmer M, "Dynamics of metatranscription in the inflammatory bowel disease gut microbiome", Nat Microbiol, 3(3), pp.337~346 (2018)
  26. Franzosa EA, "Relating the metatranscriptome and metagenome of the human gut", Proc Natl Acad Sci U S A, 111(22), pp.E2329~38 (2014)
  27. Matsumoto M, "Voluntary running exercise alters microbiota composition and increases nbutyrate concentration in the rat cecum", Biosci Biotechnol Biochem, 72(2), pp.572~576 (2008)
  28. Batacan RB, "A gut reaction : the combined influence of exercise and diet on gastrointestinal microbiota in rats", J Appl Microbiol, 122(6), pp.1627~1638 (2017)
  29. Welly RJ, "Comparison of diet versus exercise on metabolic function and gut microbiota in obese rats", Med Sci Sports Exerc, 48(9), pp.1688~1698 (2016)
  30. Lamoureux EV, "Moderate exercise has limited but distinguishable effects on the mouse microbiome", mSystems, 2(4) (2017)
  31. Liu TW, "Physical activity differentially affects the cecal microbiota of ovariectomized female rats selectively bred for high and low aerobic capacity", PLoS One, 10(8), pp.e0136150~ (2015)
  32. Allen JM, "Voluntary and forced exercise differentially alters the gut microbiome in C57BL", 6J mice, 2015, pp.118(8), 1059~1066
  33. Campbell SC, "The effect of diet and exercise on intestinal integrity and microbial diversity in mice", PLoS One, 11(3), pp.e0150502~ (2016)
  34. Mika A, "Exercise is more effective at altering gut microbial composition and producing stable changes in lean mass in juvenile versus adult male F344rats", PLoS One, 10(5), pp.e0125889~ (2015)
  35. Denou E, "Highintensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity", Am J Physiol Endocrinol Metab, 310(11), pp.E982~93 (2016)
  36. Queipo-Ortuno MI, "Gut microbiota composition in male rat models under different nutritional status and physical activity and its association with serum leptin and ghrelin levels", PLoS One, 8(5), pp.e65465~ (2013)
  37. Evans CC, "Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity", PLoS One, 9(3), pp.e92193~ (2014)
  38. Lambert JE, "Exercise training modifies gut microbiota in normal and diabetic mice", Appl Physiol Nutr Metab, 40(7), pp.749~752 (2015)
  39. Petriz BA, "Exercise induction of gut microbiota modifications in obese, nonobese and hypertensive rats", BMC Genomics, 15, pp.511~ (2014)
  40. Kang SS, "Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition", Mol Neurodegener, 9, pp.36~ (2014)
  41. Peng L, "Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers", J Nutr, 139(9), pp.1619~1625 (2009)
  42. Saemann MD, "Anti-inflammatory effects of sodium butyrate on human monocytes : potent inhibition of IL-12 and up-regulation of IL-10 production", FASEB J, 14(15), pp.2380~2382 (2000)
  43. Allen JM, "Exercise alters gut microbiota composition and function in lean and obese humans", Med Sci Sports Exerc, 50(4), pp.747~757 (2018)
  44. Cronin O, "A prospective metagenomic and metabolomic analysis of the impact of exercise and", or whey protein supplementation on the gut microbiome of sedentary adults, 2018, pp.3(3), ~
  45. Munukka E, "Sixweek endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women", Front Microbiol, 9, pp.2323~ (2018)
  46. Clarke SF, "Exercise and associated dietary extremes impact on gut microbial diversity", Gut, 63(12), pp.1913~1920 (2014)
  47. Louis P, "Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine", FEMS Microbiol Lett, 294(1), pp.1~8 (2009)
  48. Dao MC, "Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity : relationship with gut microbiome richness and ecology", Gut, 65(3), pp.426~436 (2016)
  49. Durk RP, "Gut microbiota composition is related to cardiorespiratory fitness in healthy young adults", Int J Sport Nutr Exerc Metab, 29(3), pp.249~253 (2019)
  50. Estaki M, "Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions", Microbiome, 4(1), pp.42~ (2016)
  51. Barton W, "The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level", Gut, 67(4), pp.625~633 (2018)
  52. Furber MJW, "Gut micro bial stability is associated with greater endurance performance in athletes undertaking dietary periodization", mSystems, 7(3), pp.e0012922~ (2022)
  53. Scheiman J, "Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism", Nat Med, 25(7), pp.1104~1109 (2019)

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