Expanding roles of centrosome abnormalities in cancers
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Centrosome abnormalities are hallmarks of human cancers. Structuraland numerical centrosome abnormalities correlate withtumor aggressiveness and poor prognosis, implicating that centrosomeabnormalities could be a cause of tumorigenesis. SinceBoveri made his pioneering recognition of the potential causallink between centrosome abnormalities and cancer more thana century ago, there has been significant progress in the field. Here, we review recent advances in the understanding of thecauses and consequences of centrosome abnormalities and theirconnection to cancers. Centrosome abnormalities can drive theinitiation and progression of cancers in multiple ways. For example,they can generate chromosome instability through abnormalmitosis, accelerating cancer genome evolution. Remarkably, itis becoming clear that the mechanisms by which centrosomeabnormalities promote several steps of tumorigenesis are far beyondwhat Boveri had initially envisioned. We highlight variouscancer-promoting mechanisms exerted by cells with centrosomeabnormalities and how these cells possessing oncogenic potentialcan be monitored.
Abstract
Centrosome abnormalities are hallmarks of human cancers. Structuraland numerical centrosome abnormalities correlate withtumor aggressiveness and poor prognosis, implicating that centrosomeabnormalities could be a cause of tumorigenesis. SinceBoveri made his pioneering recognition of the potential causallink between centrosome abnormalities and cancer more thana century ago, there has been significant progress in the field. Here, we review recent advances in the understanding of thecauses and consequences of centrosome abnormalities and theirconnection to cancers. Centrosome abnormalities can drive theinitiation and progression of cancers in multiple ways. For example,they can generate chromosome instability through abnormalmitosis, accelerating cancer genome evolution. Remarkably, itis becoming clear that the mechanisms by which centrosomeabnormalities promote several steps of tumorigenesis are far beyondwhat Boveri had initially envisioned. We highlight variouscancer-promoting mechanisms exerted by cells with centrosomeabnormalities and how these cells possessing oncogenic potentialcan be monitored.
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