Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis

참고문헌 (142)

1. Hu, C., "ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN", PI3K, Int. J. Oncol, pp.2019, 55[DOI]
2. Peng, Y., "ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness", Acta Biomater, 88, pp.86~101 (2019)
3. Rizki, A., "Polo-like kinase 1 is involved in invasion through extracellular matrix", Cancer Res, 67, pp.11106~11110 (2007)
4. Wu, J., "Polo-like kinase 1 induces epithelial-tomesenchymal transition and promotes epithelial cell motility by activating CRAF", ERK signaling, 2016, pp.5, e10734~
5. D’assoro, A., "The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells", Oncogene, 33, pp.599~610 (2014)
6. Qi, G., "Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer", Virchows Arch, 450, pp.297~302 (2007)
7. Song, H., "Aurora-B promotes osteosarcoma cell growth and metastasis through activation of the NPM1", ERK, MMPs axis, pp.Cancer Manag. Res, 2020[DOI]
8. Zhang, J., "Aurora B induces epithelial-mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis", Oncogene, 39, pp.2550~2567 (2020)
9. Huang, G. X., "Up-regulation of Rho-associated kinase 1", 2 by glucocorticoids promotes migration, invasion and metastasis of melanoma, 2017, pp.410, 1~11
10. Fielding, A. B., "Beyond focal adhesions: integrin-linked kinase associates with tubulin and regulates mitotic spindle organization", Cell Cycle, 7, pp.1899~1906 (2008)
11. Gupton, S. L., "Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration", Cell, 125, pp.1361~1374 (2006)
12. Lock, J. G., "Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis", Nat. Cell Biol, 20, pp.1290~1302 (2018)
13. Matthews, H. K., "The metastatic cancer cell cortex: an adaptation to enhance robust cell division in novel environments?", Bioessays, 34, pp.1017~1020 (2012)
14. Shin, S. B., "Active PLK1-driven metastasis is amplified by TGF-beta signaling that forms a positive feedback loop in nonsmall cell lung cancer", Oncogene, 39, pp.767~785 (2020)
15. Jang, H. -R., "PLK1", vimentin signaling facilitates immune escape by recruiting Smad2, Cell Death Differ, pp.2021, 28[DOI]
16. Yamaguchi, T., "Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis", J. Cell Biol, 171, pp.431~436 (2005)
17. Bakhoum, S. F., "Chromosomal instability drives metastasis through a cytosolic DNA response", Nature, 553, pp.467~472 (2018)
18. Dillekås, H., "Are 90% of deaths from cancer caused by metastases?", Cancer Med, 8, pp.5574~5576 (2019)
19. Fife, C. M., "Movers and shakers: cell cytoskeleton in cancer metastasis", Br. J. Pharm, 171, pp.5507~5523 (2014)
20. Kirschner, M., "Beyond self-assembly: from microtubules to morphogenesis", Cell, 45, pp.329~342 (1986)
21. Gadde, S., "Mechanisms and molecules of the mitotic spindle", Curr. Biol, 14, pp.R797~R805 (2004)
22. Casenghi, M., "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation", Dev. Cell, 5, pp.113~125 (2003)
23. Hoffmann, I., "Centrosomes in mitotic spindle assembly and orientation", Curr. Opin. Struct. Biol, 66, pp.193~198 (2021)
24. Cheffings, T. H., "Actomyosin ring formation and tension generation in eukaryotic cytokinesis", Curr. Biol, 26, pp.R719~R737 (2016)
25. Wu, Q., "Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells", Oncogene, 29, pp.4183~4193 (2010)
26. Drechsel, D. N., "A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos", Curr. Biol, 7, pp.12~23 (1997)
27. Su Pin Koh, "Seeing is believing: tools to study the role of Rho GTPases during cytokinesis", Small GTPases, 13(1), pp.211~224 (2021), Informa UK Limited[DOI]
28. Niiya, F., "Phosphorylation of the cytokinesis regulator ECT2 at G2", M phase stimulates association of the mitotic kinase Plk1and accumulation of GTP-bound RhoA, 2006, pp.25, 827~837
29. Patel, S. A., "Genomic control of metastasis", Br. J. Cancer, 124, pp.3~12 (2021)
30. Xu, R., "Roles of the phosphorylation of transcriptional factors in epithelial-mesenchymal transition", J. Oncol, 2019, pp.5810465~ (2019)
31. Tam, W. L., "The epigenetics of epithelial-mesenchymal plasticity in cancer", Nat. Med, 19, pp.1438~1449 (2013)
32. Palmer, T. D., "Targeting tumor cell motility to prevent metastasis", Adv. Drug Deliv. Rev, 63, pp.568~581 (2011)
33. Ridley, A. J., "Cell migration: integrating signals from front to back", Science, 302, pp.1704~1709 (2003)
34. Yim, H., "Plk1-targeted therapies in TP53-or RAS-mutated cancer", Mutat. Res., Rev. Mutat. Res, 761, pp.31~39 (2014)
35. Liu, X. S., "The substrates of Plk1, beyond the functions in mitosis", Protein Cell, 1, pp.999~1010 (2010)
36. Elowe, S., "Tension-sensitive Plk1phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions", Genes Dev, 21, pp.2205~2219 (2007)
37. Gheghiani, L., "PLK1 activation in late G2 sets up commitment to mitosis", Cell Rep, 19, pp.2060~2073 (2017)
38. Burkard, M. E., "Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells", PLoS Biol, 7, pp.e1000111~ (2009)
39. Li, H., "Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments", EMBO J, 29, pp.2953~2965 (2010)
40. Budde, P. P., "Regulation of Op18 during spindle assembly in Xenopus egg extracts", J. Cell Biol, 153, pp.149~158 (2001)
41. Yarm, F. R., "Plk phosphorylation regulates the microtubule-stabilizing protein TCTP", Mol. Cell. Biol, 22, pp.6209~6221 (2002)
42. Fukata, M., "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170", Cell, 109, pp.873~885 (2002)
43. Zhang, L., "PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity", J. Biol. Chem, 286, pp.3033~3046 (2011)
44. Smith, M. R., "Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase", Biochem. Biophys. Res. Commun, 234, pp.397~405 (1997)
45. Gheghiani, L., "PLK1 induces chromosomal instability and overrides cellcycle checkpoints to drive tumorigenesis", Cancer Res, 81, pp.1293~1307 (2021)
46. Knecht, R., "Prognostic significance of polo-like kinase(PLK)expression in squamous cell carcinomas of the head and neck", Cancer Res, 59, pp.2794~2797 (1999)
47. Weichert, W., "Polo-like kinase 1 expression is a prognostic factor in human colon cancer", World J. Gastroentero, 11, pp.5644~5650 (2005)
48. Weichert, W., "Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades", Prostate, 60, pp.240~245 (2004)
49. Wolf, G., "Prognostic significance of polo-like kinase(PLK)expression in nonsmall cell lung cancer", Oncogene, 14, pp.543~549 (1997)
50. Zhang, Y., "Augmented expression of polo-like kinase 1 indicates poor clinical outcome for breast patients : a systematic review and meta-analysis", Oncotarget, 8, pp.57723~57732 (2017)
51. Tokumitsu, Y., "Prognostic significance of polo-like kinase expression in esophageal carcinoma", Int. J. Oncol, 15, pp.687~692 (1999)
52. Takai, N., "Polo-like kinase(PLK)expression in endometrial carcinoma", Cancer Lett, 169, pp.41~49 (2001)
53. Takai, N., "Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage", Cancer Lett, 164, pp.41~49 (2001)
54. Zhang, Z., "High expression of polo-like kinase 1 is associated with the metastasis and recurrence in urothelial carcinoma of bladder", Urologic Oncol, 31, pp.1222~1230 (2013)
55. Nowakowski, J., "Structures of the cancer-related Aurora-A, FAK, and EphA2protein kinases from nanovolume crystallography", Structure, 10, pp.1659~1667 (2002)
56. Glover, D. M., "Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles", Cell, 81, pp.95~105 (1995)
57. Cazales, M., "CDC25B phosphorylation by Aurora A occurs at the G2", M transition and is inhibited by DNA damage, 2005, pp.4, 1233~1238
58. Dutertre, S., "Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition", J. Cell Sci, 117, pp.2523~2531 (2004)
59. Kinoshita, K., "Aurora A phosphorylation of TACC3", maskin is required for centrosome-dependent microtubule assembly in mitosis, 2005, pp.170, 1047~1055
60. Kunitoku, N., "CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function", Developmental Cell, 5, pp.853~864 (2003)
61. Ritchey, L., "Aurora A kinase modulates actin cytoskeleton through phosphorylation of Cofilin : Implication in the mitotic process", Biochim. Biophys. Acta, 1843, pp.2719~2729 (2014)
62. Reboutier, D., "Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued", J. Cell Biol, 201, pp.65~79 (2013)
63. Ertych, N., "CHK2-BRCA1 tumorsuppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly", Proc. Natl Acad. Sci, 113, pp.1817~1822 (2016)
64. Wong, J., "Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain", Mol. Biol. Cell, 19, pp.2083~2091 (2008)
65. Yu, C. T., "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A", Mol. Cell. Biol, 25, pp.5789~5800 (2005)
66. Venoux, M., "ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis", Hum. Mol. Genet, 17, pp.215~224 (2008)
67. Gritsko, T. M., "Activation and overexpression of centrosome kinase BTAK", Aurora-A in human ovarian cancer, 2003, pp.9, 1420~1426
68. Lim, K. H., "Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA", Mol. Cell. Biol, 30, pp.508~523 (2010)
69. Liu, Q., "Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215", J. Biol. Chem, 279, pp.52175~52182 (2004)
70. Jeng, Y. M., "Overexpression and amplification of Aurora-A in hepatocellular carcinoma", Clin. Cancer Res, 10, pp.2065~2071 (2004)
71. Nadler, Y., "Expression of Aurora A(but not Aurora B)is predictive of survival in breast cancer", Clin. Cancer Res, 14, pp.4455~4462 (2008)
72. Lassmann, S., "Aurora-a is a predictive marker for stage III epithelial ovarian cancers", Verhandlungen der Dtsch. Ges. fur Pathologie, 91, pp.225~232 (2007)
73. Wang, J., "Aurora-A as an independent molecular prognostic marker in gastric cancer", Oncol. Rep, 26, pp.23~32 (2011)
74. 고현민, "Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma", Journal of Pathology and Translational Medicine, 51(1), pp.32~39 (2017), 대한병리학회[DOI]
75. Xu, J., "Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis", J. Transl. Med, 12, pp.200~ (2014)
76. Fadaka, A. O., "MicroRNA-based regulation of Aurora A kinase in breast cancer", Oncotarget, 11, pp.4306~4324 (2020)
77. Iacono, M. L., "Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation", J. Transl. Med, 9, pp.1~6 (2011)
78. Wang, L. H., "The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway", Cancer Res, 70, pp.9118~9128 (2010)
79. Wang, X., "Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells", Mol. Cancer Res, 10, pp.588~596 (2012)
80. He, J. G., "Aurora-A regulates progression and metastasis of colorectal cancer by promoting slug activity", Technol. Cancer Res. Treat, 16, pp.766~775 (2017)
81. Wang, J., "The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma", J. Cell Sci, 130, pp.1078~1093 (2017)
82. Wu, J. -C., "Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening", J. Biol. Chem, 280, pp.9013~9022 (2005)
83. Maimaiti, Y., "Aurora kinase A induces papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity", Biochem. Biophys. Res. Commun, 473, pp.212~218 (2016)
84. Minoshima, Y., "Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis", Developmental Cell, 4, pp.549~560 (2003)
85. Kawajiri, A., "Functional significance of the specific sites phosphorylated in desmin at cleavage furrow : Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase", Mol. Biol. Cell, 14, pp.1489~1500 (2003)
86. Delaval, B., "Aurora B-TACC1 protein complex in cytokinesis", Oncogene, 23, pp.4516~4522 (2004)
87. Ritter, A., "Functional analysis of phosphorylation of the mitotic centromereassociated kinesin by Aurora B kinase in human tumor cells", Cell Cycle, 14, pp.3755~3767 (2015)
88. Guse, A., "Phosphorylation of ZEN-4", MKLP1 by aurora B regulates completion of cytokinesis, 2005, pp.15, 778~786
89. Goto, H., "Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process", J. Biol. Chem, 278, pp.8526~8530 (2003)
90. Zhang, Y., "Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer", Int. J. Clin. Exp. Pathol, 8, pp.751~757 (2015)
91. Takeshita, M., "Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer", Lung Cancer, 80, pp.85~90 (2013)
92. Wang, Z., "AURKB promotes the metastasis of gastric cancer, possibly by inducing EMT", Cancer Manag. Res, 12, pp.6947~6958 (2020)
93. Lin, W. R., "The histogenesis of regenerative nodules in human liver cirrhosis", Hepatology, 51, pp.1017~1026 (2010)
94. Chen, Y. J., "Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients", Virchows Arch, 455, pp.431~440 (2009)
95. Chieffi, P., "Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation", Prostate, 66, pp.326~333 (2006)
96. Tatsuka, M., "Multinuclearity and increased ploidy caused by overexpression of the aurora-and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells", Cancer Res, 58, pp.4811~4816 (1998)
97. Sorrentino, R., "Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation", J. Clin. Endocrinol. Metab, 90, pp.928~935 (2005)
98. Zeng, W. F., "Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme", J. Clin. Pathol, 60, pp.218~221 (2007)
99. Yu, J., "High expression of Aurora-B is correlated with poor prognosis and drug resistance in non-small cell lung cancer", Int. J. Biol. Markers, 33, pp.215~221 (2018)
100. Hetland, T. E., "Aurora B expression in metastatic effusions from advancedstage ovarian serous carcinoma is predictive of intrinsic chemotherapy resistance", Hum. Pathol, 44, pp.777~785 (2013)
101. Zhu, L. B., "Knockdown of Aurora-B inhibits osteosarcoma cell invasion and migration via modulating PI3K", Akt, Int. J. Clin. Exp. Pathol, pp.2014, 7[DOI]
102. Kumper, S., "Rho-associated kinase(ROCK)function is essential for cell cycle progression, senescence and tumorigenesis", Elife, 5, pp.e12994~ (2016)
103. Shi, J., "Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment", Cell Death Dis, 4, pp.e483~ (2013)
104. Wei, L., "Novel Insights into the roles of rho kinase in cancer", Arch. Immunol. Ther. Exp. (Warsz. ), 64, pp.259~278 (2016)
105. Nakagawa, O., "ROCK-I and ROCK-II, two isoforms of Rho-associated coiledcoil forming protein serine", threonine kinase in mice, 1996, pp.392, 189~193
106. Wen, W., "Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinases", J. Biol. Chem, 283, pp.26263~26273 (2008)
107. Hartmann, S., "The function of rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease", Front. Pharmacol, 6, pp.276~ (2015)
108. Ohashi, K., "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop", J. Biol. Chem, 275, pp.3577~3582 (2000)
109. Wu, H., "Targeting ROCK1", 2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma, 2021, pp.184, 114353~
110. Goto, H., "Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis", J. Biol. Chem, 273, pp.11728~11736 (1998)
111. Khasnis, M., "Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1", Biochemistry, 53, pp.2701~2709 (2014)
112. Croft, D. R., "Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis", Cancer Res, 64, pp.8994~9001 (2004)
113. Xu, S., "Macrophage migration inhibitory factor enhances autophagy by regulating ROCK1 activity and contributes to the escape of dendritic cell surveillance in glioblastoma", Int. J. Oncol, 49, pp.2105~2115 (2016)
114. Zhan, Y., "MiR-199a", b-5p inhibits hepatocellular carcinoma progression by post-transcriptionally suppressing ROCK1, 2017, pp.8, 67169~67180
115. Luo, D., "Activation of the ROCK1", MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma, 2017, pp.51, 1209~1218
116. Wang, Z., "Long non-coding RNA SNHG5 sponges miR-26a to promote the tumorigenesis of osteosarcoma by targeting ROCK1", Biomed. Pharmacother, 107, pp.598~605 (2018)
117. Kamai, T., "Significant association of Rho", ROCK pathway with invasion and metastasis of bladder cancer, 2003, pp.9, 2632~2641
118. Mei, Y., "Overexpression of ROCK1 promotes cancer cell proliferation and is associated with poor prognosis in human urothelial bladder cancer", Mamm. Genome, 32, pp.466~475 (2021)
119. Xin, T., "ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway", Aging(Albany NY), 12, pp.12160~12174 (2020)
120. Liu, S., "Inhibition of rhoassociated kinase signaling prevents breast cancer metastasis to human bone", Cancer Res, 69, pp.8742~8751 (2009)
121. Zhang, C., "ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc", Oncogene, 33, pp.5582~5591 (2014)
122. Hannigan, G., "Integrin-linked kinase: a cancer therapeutic target unique among its ILK", Nat. Rev. Cancer, 5, pp.51~63 (2005)
123. Dobreva, I., "Mapping the integrin-linked kinase interactome using SILAC", J. Proteome Res, 7, pp.1740~1749 (2008)
124. Bettencourt-Dias, M., "Genome-wide survey of protein kinases required for cell cycle progression", Nature, 432, pp.980~987 (2004)
125. Fielding, A. B., "The mitotic functions of integrin-linked kinase", Cancer Metastasis Rev, 28, pp.99~111 (2009)
126. Delcommenne, M., "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B", AKT by the integrin-linked kinase, 1998, pp.95, 11211~11216
127. Wakefield, J. G., "A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment", J. Cell Sci, 116, pp.637~646 (2003)
128. Troussard, A. A., "Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B", Akt activation, 2003, pp.278, 22374~22378
129. Takanami, I., "Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer", BMC Cancer, 5, pp.1~ (2005)
130. Koul, D., "Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma", Mol. Cancer Ther, 4, pp.1681~1688 (2005)
131. Tsirtsaki, K., "The focal adhesion protein Integrin-Linked Kinase(ILK)as an important player in breast cancer pathogenesis", Cell. Adh. Migr, 14, pp.204~213 (2020)
132. Tsoumas, D., "ILK expression in colorectal cancer is associated with EMT, cancer stem cell markers and chemoresistance", Cancer Genomics Proteom, 15, pp.127~141 (2018)
133. Okamura, M., "Prognostic value of integrin β1-ILK-pAkt signaling pathway in non–small cell lung cancer", Hum. Pathol, 38, pp.1081~1091 (2007)
134. Zheng, C. C., "Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer", Am. J. Cancer Res, 9, pp.186~197 (2019)
135. Filipenko, N. R., "Integrin-linked kinase activity regulates Rac-and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX", Oncogene, 24, pp.5837~5849 (2005)
136. Tan, C., "Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef", Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−, Oncogene, pp.2001, 20[DOI]
137. Deng, J. T., "Ca. sup. 2+. independent smooth muscle contraction. a novel function for integrin-linked kinase", J. Biol. Chem, 276, pp.16365~16373 (2001)
138. Deng, J. T., "Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase", Biochemical J, 367, pp.517~524 (2002)
139. Shirley, L. A., "Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target", Surgery, 159, pp.163~171 (2016)
140. Feng, J., "Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase", J. Biol. Chem, 274, pp.37385~37390 (1999)
141. McDonald, P. C., "Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival", Cancer Res, 68, pp.1618~1624 (2008)
142. Tan, C., "Regulation of tumor angiogenesis by integrin-linked kinase (ILK)", Cancer Cell, 5, pp.79~90 (2004)

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