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The role of diuretic hormones (DHs) and their receptors in Drosophila

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초록

Maintaining internal homeostasis and regulating innate behaviorsare essential for animal survival. In various animal species, ahighly conserved neuroendocrine system integrates sensory inputsand regulates physiological responses to environmental andinternal changes. Diuretic hormones 44 and 31, which are homologsof mammalian corticotropin-releasing factor (CRF) and calcitoningene-related peptide (CGRP), respectively, control bodyfluid secretion in Drosophila. These neuropeptides and their receptorshave multiple physiological roles, including the regulationof body-fluid secretion, sleep:wake cycle, internal nutrientsensing,and CO2-dependent response. This review discussesthe physiological and behavioral roles of DH44 and DH31signaling pathways, consisting of neuroendocrine cells thatsecrete DH44 or DH31 peptides and their receptor-expressingorgans. Further research is needed to understand the regulatorymechanisms of the behavioral processes mediated by these neuroendocrinesystems.

Abstract

Maintaining internal homeostasis and regulating innate behaviorsare essential for animal survival. In various animal species, ahighly conserved neuroendocrine system integrates sensory inputsand regulates physiological responses to environmental andinternal changes. Diuretic hormones 44 and 31, which are homologsof mammalian corticotropin-releasing factor (CRF) and calcitoningene-related peptide (CGRP), respectively, control bodyfluid secretion in Drosophila. These neuropeptides and their receptorshave multiple physiological roles, including the regulationof body-fluid secretion, sleep:wake cycle, internal nutrientsensing,and CO2-dependent response. This review discussesthe physiological and behavioral roles of DH44 and DH31signaling pathways, consisting of neuroendocrine cells thatsecrete DH44 or DH31 peptides and their receptor-expressingorgans. Further research is needed to understand the regulatorymechanisms of the behavioral processes mediated by these neuroendocrinesystems.

참고문헌 (57)

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