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Polo-like kinase-1 in DNA damage response

장영주|현선이|황효인
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.05|BMB Reports|제47권 제5호|pp. 249-255

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키워드

p53Cell cycleDNA damage checkpointPolo-like kinase-1
주제분류화학

초록

Polo-like kinase-1 (Plk1) belongs to a family of serine-threoninekinases and plays a critical role in mitotic progression. Plk1involves in the initiation of mitosis, centrosome maturation,bipolar spindle formation, and cytokinesis, well-reported astraditional functions of Plk1. In this review, we discuss the roleof Plk1 during DNA damage response beyond the functions inmitotsis. When DNA is damaged in cells under various stressconditions, the checkpoint mechanism is activated to allowcells to have enough time for repair. When damage is repaired,cells progress continuously their division, which is calledcheckpoint recovery. If damage is too severe to repair, cellsundergo apoptotic pathway. If damage is not completelyrepaired, cells undergo a process called checkpoint adaptation,and resume cell division cycle with damaged DNA. Plk1targets and regulates many key factors in the process of damageresponse, and we deal with these subjects in this review.

Abstract

Polo-like kinase-1 (Plk1) belongs to a family of serine-threoninekinases and plays a critical role in mitotic progression. Plk1involves in the initiation of mitosis, centrosome maturation,bipolar spindle formation, and cytokinesis, well-reported astraditional functions of Plk1. In this review, we discuss the roleof Plk1 during DNA damage response beyond the functions inmitotsis. When DNA is damaged in cells under various stressconditions, the checkpoint mechanism is activated to allowcells to have enough time for repair. When damage is repaired,cells progress continuously their division, which is calledcheckpoint recovery. If damage is too severe to repair, cellsundergo apoptotic pathway. If damage is not completelyrepaired, cells undergo a process called checkpoint adaptation,and resume cell division cycle with damaged DNA. Plk1targets and regulates many key factors in the process of damageresponse, and we deal with these subjects in this review.

참고문헌 (84)

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