Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types

키워드

참고문헌 (74)

1. Bielski CM, "Genome doubling shapes the evolution and prognosis of advanced cancers", Nat Genet, 50, pp.1189~1195 (2018)
2. Quinton RJ, "Whole-genome doubling confers unique genetic vulnerabilities on tumour cells", Nature, 590, pp.492~497 (2021)
3. Gillette MA, "Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma", Cell, 182, pp.200~225 (2020)
4. Dewhurst SM, "Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution", Cancer Discov, 4, pp.175~185 (2014)
5. Lopez S, "Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution", Nat Genet, 52, pp.283~293 (2020)
6. Ganem NJ, "Limiting the proliferation of polyploid cells", Cell, 131, pp.437~440 (2007)
7. Fujiwara T, "Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells", Nature, 437, pp.1043~1047 (2005)
8. Ganem NJ, "Cytokinesis failure triggers hippo tumor suppressor pathway activation", Cell, 158, pp.833~848 (2014)
9. Senovilla L, "An immunosurveillance mechanism controls cancer cell ploidy", Science, 337, pp.1678~1684 (2012)
10. Andreassen PR, "Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1", Mol Biol Cell, 12, pp.1315~1328 (2001)
11. Sanz-Gomez N, "Whole-genome doubling as a source of cancer : how, when, where, and why?", Front Cell Dev Biol, 11, pp.1209136~ (2023)
12. Davoli T, "Persistent telomere damage induces bypass of mitosis and tetraploidy", Cell, 141, pp.81~93 (2010)
13. Jeong HC, "Timely degradation of Wip1 phosphatase by APC", C activator protein Cdh1 is necessary for normal mitotic progression, 2015, pp.116, 1602~1612
14. Zeng J, "Cyclin E-induced replicative stress drives p53-dependent wholegenome duplication", Cell, 186, pp.528~542 (2023)
15. Brito DA, "Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint", Curr Biol, 16, pp.1194~1200 (2006)
16. Shi Q, "Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines", Nature, 437, pp.1038~1042 (2005)
17. Duelli DM, "A virus causes cancer by inducing massive chromosomal instability through cell fusion", Curr Biol, 17, pp.431~437 (2007)
18. Overholtzer M, "A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion", Cell, 131, pp.966~979 (2007)
19. Krajcovic M, "A nongenetic route to aneuploidy in human cancers", Nat Cell Biol, 13, pp.324~330 (2011)
20. Gjelsvik KJ, "Solving the polyploid mystery in health and disease", Trends Genet, 35, pp.6~14 (2019)
21. Edgar BA, "Endocycles : a recurrent evolutionary innovation for post-mitotic cell growth", Nat Rev Mol Cell Biol, 15, pp.197~210 (2014)
22. Duncan AW, "The ploidy conveyor of mature hepatocytes as a source of genetic variation", Nature, 467, pp.707~710 (2010)
23. Al-Rawi DH, "Chromosomal instability as a source of genomic plasticity", Curr Opin Genet Dev, 74, pp.101913~ (2022)
24. Olaharski AJ, "Tetraploidy and chromosomal instability are early events during cervical carcinogenesis", Carcinogenesis, 27, pp.337~343 (2006)
25. Song S, "Expanding roles of centrosome abnormalities in cancers", BMB Rep, 56, pp.216~224 (2023)
26. King RW, "When 2+2=5 : the origins and fates of aneuploid and tetraploid cells", Biochim Biophys Acta, 1786, pp.4~14 (2008)
27. Coward J, "Size does matter : why polyploid tumor cells are critical drug targets in the war on cancer", Front Oncol, 4, pp.123~ (2014)
28. Zhang J, "Human cell polyploidization : the good and the evil", Semin Cancer Biol, 81, pp.54~63 (2022)
29. Lambuta RA, "Whole-genome doubling drives oncogenic loss of chromatin segregation", Nature, 615, pp.925~933 (2023)
30. Gemble S, "Genetic instability from a single S phase after whole-genome duplication", Nature, 604, pp.146~151 (2022)
31. Andreassen PR, "Neither p21WAF1 nor 14-3-3σ prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1arrest in resulting tetraploid cells", Cancer Res, 61, pp.7660~7668 (2001)
32. Jo Y, "Repression of the F-box protein Skp2 is essential for actin damage-induced tetraploid G1arrest", BMB Rep, 50, pp.379~383 (2017)
33. Aylon Y, "The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1", Genes Dev, 24, pp.2420~2429 (2010)
34. Carter SL, "Absolute quantification of somatic DNA alterations in human cancer", Nat Biotechnol, 30, pp.413~421 (2012)
35. Taylor AM, "Genomic and functional approaches to understanding cancer aneuploidy", Cancer Cell, 33, pp.676~689 (2018)
36. Steele CD, "Signatures of copy number alterations in human cancer", Nature, 606, pp.984~991 (2022)
37. Shen R, "FACETS : allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing", Nucleic Acids Res, 44, pp.e131~ (2016)
38. Priestley P, "Pan-cancer whole-genome analyses of metastatic solid tumours", Nature, 575, pp.210~216 (2019)
40. Frankell AM, "The evolution of lung cancer and impact of subclonal selection in TRACERx", Nature, 616, pp.525~533 (2023)
41. Offin M, "Concurrent RB1and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes", J Thorac Oncol, 14, pp.1784~1793 (2019)
42. Zhang T, "Genomic and evolutionary classification of lung cancer in never smokers", Nat Genet, 53, pp.1348~1359 (2021)
43. Nahar R, "Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing", Nat Commun, 9, pp.216~ (2018)
44. De Bruin EC, "Spatial and temporal diversity in genomic instability processes defines lung cancer evolution", Science, 346, pp.251~256 (2014)
45. Choudhary A, "Identification of selective lead compounds for treatment of high-ploidy breast cancer", Mol Cancer Ther, 15, pp.48~59 (2016)
46. Newcomb R, "Context-dependent effects of whole-genome duplication during mammary tumor recurrence", Sci Rep, 11, pp.14932~ (2021)
47. Minussi DC, "Breast tumours maintain a reservoir of subclonal diversity during expansion", Nature, 592, pp.302~308 (2021)
48. Berenjeno IM, "Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling", Nat Commun, 8, pp.1773~ (2017)
49. Yates LR, "Genomic evolution of breast cancer metastasis and relapse", Cancer Cell, 32, pp.169~184 (2017)
50. Guinney J, "The consensus molecular subtypes of colorectal cancer", Nat Med, 21, pp.1350~1356 (2015)
51. Kim JE, "High prevalence of TP53 loss and whole-genome doubling in early-onset colorectal cancer", Exp Mol Med, 53, pp.446~456 (2021)
52. Cohen-Sharir Y, "Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition", Nature, 590, pp.486~491 (2021)
53. Kabel J, "Impact of whole genome doubling on detection of circulating tumor DNA in colorectal cancer", Cancers, 15, pp.1136~ (2023)
54. Vigano C, "Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability", Mol Biol Cell, 29, pp.1031~1047 (2018)
55. Chan-Seng-Yue M, "Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution", Nat Genet, 52, pp.231~240 (2020)
56. Sakamoto H, "The evolutionary origins of recurrent pancreatic cancer", Cancer Discov, 10, pp.792~805 (2020)
57. Notta F, "A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns", Nature, 538, pp.378~382 (2016)
58. Baslan T, "Ordered and deterministic cancer genome evolution after p53 loss", Nature, 608, pp.795~802 (2022)
59. Lopez-Gines C, "New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profile", Mod Pathol, 23, pp.856~865 (2010)
60. Hadi K, "Distinct classes of complex structural variation uncovered across thousands of cancer genome graphs", Cell, 183, pp.197~210 (2020)
61. Furgason JM, "Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma", Oncoscience, 2, pp.618~ (2015)
62. Castro MP, "Targeting chromosome 12q amplification in relapsed glioblastoma : the use of computational biological modeling to identify effective therapy-a case report", Ann Transl Med, 10, pp.1289~ (2022)
63. Walentynowicz KA, "Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma", Cell Rep, 42, pp.112235~ (2023)
64. Favero F, "Glioblastoma adaptation traced through decline of an IDH1clonal driver and macro-evolution of a double-minute chromosome", Ann Oncol, 26, pp.880~887 (2015)
65. Heo YJ, "Integrative multi-omics approaches in cancer research : from biological networks to clinical subtypes", Mol Cells, 44, pp.433~443 (2021)
66. Satpathy S, "A proteogenomic portrait of lung squamous cell carcinoma", Cell, 184, pp.4348~4371 (2021)
67. Krug K, "Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy", Cell, 183, pp.1436~1456 (2020)
68. Huang C, "Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma", Cancer Cell, 39, pp.361~379 (2021)
69. Dou Y, "Proteogenomic characterization of endometrial carcinoma", Cell, 180, pp.729~748 (2020)
70. Cao L, "Proteogenomic characterization of pancreatic ductal adenocarcinoma", Cell, 184, pp.5031~5052 (2021)
71. Wang LB, "Proteogenomic and metabolomic characterization of human glioblastoma", Cancer Cell, 39, pp.509~528 (2021)
72. Vasaikar S, "Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities", Cell, 177, pp.1035~1049 (2019)
74. Alexandrov LB, "The repertoire of mutational signatures in human cancer", Nature, 578, pp.94~101 (2020)

관련 논문AI추천