영여자 추출물의 주름개선 효능 연구
Study on bulbil extract of Chinese yam as anti-aging material
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The aging process is caused by various factors. Inflammation is one of the most significant factors inducing skin aging. interferon-gamma(IFN-γ) signal pathway has begun to receive attention as an important aging factor. A previous study showed that an increase in the level of IFN-γ was correlated with age. Another study determined that IFN-γ inhibited the transcription of collagen. This study was carried out to evaluate the anti-aging effect of bulbuil of Chinese yam (Dioscorea batatas Dence), a species in the yam family, on human fibroblast cell. Since the use of the bulbil as food source has been limited due to its toxic potentials when consumed, tons of the bulbils has been discarded as waste. Diosgenin was confirmed as a marker compound of bulbil extract by GC-MS after chemical derivatization. Inhibitory effect of bulbil extract on activity of matrix metallo proteinase-1 (MMP-1) and activating protein-1 (AP-1) induced by interferon-gamma treatment on human fibroblast cell was evaluated. Summing up the results, bulbil extract of Chinese yam could possess great potential as a novel anti-wrinkle material for cosmetic industry
Abstract
The aging process is caused by various factors. Inflammation is one of the most significant factors inducing skin aging. interferon-gamma(IFN-γ) signal pathway has begun to receive attention as an important aging factor. A previous study showed that an increase in the level of IFN-γ was correlated with age. Another study determined that IFN-γ inhibited the transcription of collagen. This study was carried out to evaluate the anti-aging effect of bulbuil of Chinese yam (Dioscorea batatas Dence), a species in the yam family, on human fibroblast cell. Since the use of the bulbil as food source has been limited due to its toxic potentials when consumed, tons of the bulbils has been discarded as waste. Diosgenin was confirmed as a marker compound of bulbil extract by GC-MS after chemical derivatization. Inhibitory effect of bulbil extract on activity of matrix metallo proteinase-1 (MMP-1) and activating protein-1 (AP-1) induced by interferon-gamma treatment on human fibroblast cell was evaluated. Summing up the results, bulbil extract of Chinese yam could possess great potential as a novel anti-wrinkle material for cosmetic industry
참고문헌 (7)
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