2 파장 라만 산란을 이용한 비침습적 HbA1c 측정
Non-Invasive HbA1c Measurement Using Two-Wavelength Raman Scattering
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초록
The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishingthe concentrations of HbA1c control solutions at 5%, 7%, and 9%.
Abstract
The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishingthe concentrations of HbA1c control solutions at 5%, 7%, and 9%.
참고문헌 (21)
- World Health Organization(WHO), "Global Report on Diabetes" (2016), WHO press
- 이혜진, "당뇨병 진단기준으로 헤모글로빈A1C의 역할", 대한내과학회지, 79(5), pp.495~499 (2010), 대한내과학회
- Commercializations Promotion Agency for R&D Outcomes, "In Vitro Diagnostic Device Market Trend", S&T Mark. Rep, 40, pp.1~30 (2016)
- K. Lee, "Status of Non-Invasive Biometric Information Processing Technology", PD Issue Rep., 18-3(4), pp.84~106 (2018)
- W. V. Gonzales, "The Progress of Glucose Monitoring-A Review of Invasive to Minimally and Non-Invasive Techniques", Sensors, 19(4), pp.1~45 (2019)
- Cas Weykamp, "HbA1c: A Review of Analytical and Clinical Aspects", Annals of Laboratory Medicine, 33(6), pp.393~400 (2013), 대한진단검사의학회
- J. Sundararajan, "A Novel and Proven System for Non-Invasive Blood Glucose Monitoring using HbA1c", Asian J. Appl. Sci., 2(3), pp.253~274 (2009)
- R. Pandey, "Noninvasive Monitoring of Blood Glucose with Raman Spectroscopy", Acc. Chem. Res., 50(2), pp.264~272 (2017)
- T. Pan, "Quantification of gly-cated hemoglobin indicator HbA1c through near-infrared spectroscopy", J. Innov. Opt. Health Sci., 7(4), pp.1350060(1)~1350060(9) (2014)
- J. Y. Sim, "In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products", Sci. Rep., 8(1), pp.1059(1)~1059(11) (2018)
- D. M. Nathan, "Translating the A1C Assay Into Estimated Average Glucose Values", Diabetes Care, 31(8), pp.1473~1478 (2008)
- E. N. Lazareva, "Refraction, fluorescence, and Raman spectroscopy of normal and glycated hemoglobin", SPIE, 10685(1068540), pp.1~8 (2018)
- 이수석, "금 나노입자를 이용한 새로운 당화혈색소의 검출 기술", 센서학회지, 25(6), pp.435~439 (2016), 한국센서학회[DOI]
- 김형진, "반사광 측정 모드에서 금과 은의 쌍금속 표면 플라즈몬 공명 칩의 특성과 임계각을 이용한 굴절률 계산", 센서학회지, 24(6), pp.423~428 (2015), 한국센서학회[DOI]
- R. GhoshMoulick, "Compensatory secondary structure alterations in protein glycation", Biochim. Biophys. Acta, 1774(2), pp.233~242 (2007)
- A. I. Erokhin, "Temperature dependence of the refractive index in condensed media", J. Exp. Theor. Phys., 47(4), pp.669~701 (1978)
- N. Min, "Introduction to Sensor Engineering", pp.82~83 (2013), Dongilbook
- S. Lee, "Application of Analytical Chemistry of Lasers", pp.111~121 (1998), Kyungnam University Press