적외선 분광학에 의한 간질액 글루코즈 농도 측정의 정확도 향상
Accuracy improvement in the interstitial glucose measurement based on infrared spectroscopy
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Glucose concentrations in the interstitial fluid were measured based on optical spectroscopy. Prediction of glucosepreprocesing as well as by selecting an optimal wavelength region. For this purpose, artificial interstitial fluid sampleswere prepared where their glucose levels varied between 0 and 10 g/dl. Infrared spectral regions where glucose absorptionlies were investigated. A region of 1000-1500 cm1 produced the best accuracy among the regions of 1000-1500 cm1,4000-4545 cm1 and 5500-6500 cm1. Further accuracy improvement in 1000-1500 cm1 was achieved by selectingspecific wavelength bands based on a loading vector analysis method. For the samples whose glucose concentrations1. However, theloading vector optimized band of 1002-1095 cm1 reduced the prediction error up to 47 % (SEP=0.0125 g/dl andR=0.9970).
Abstract
Glucose concentrations in the interstitial fluid were measured based on optical spectroscopy. Prediction of glucosepreprocesing as well as by selecting an optimal wavelength region. For this purpose, artificial interstitial fluid sampleswere prepared where their glucose levels varied between 0 and 10 g/dl. Infrared spectral regions where glucose absorptionlies were investigated. A region of 1000-1500 cm1 produced the best accuracy among the regions of 1000-1500 cm1,4000-4545 cm1 and 5500-6500 cm1. Further accuracy improvement in 1000-1500 cm1 was achieved by selectingspecific wavelength bands based on a loading vector analysis method. For the samples whose glucose concentrations1. However, theloading vector optimized band of 1002-1095 cm1 reduced the prediction error up to 47 % (SEP=0.0125 g/dl andR=0.9970).
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