C57BL/6 마우스 모델에서 웅지(곰기름)의 모발 성장 촉진 효과 연구
Effect of Selenarctos thibetanus (bear oil) on Hair Growth Promotion in C57BL/6 Mice
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초록
The hair cycle is into 3 phases including anagen, catagen and telogen. Hair loss is the result of premature catagen caused by apoptotic signal. The process of apoptosis is controlled through the activation of many factors, such as heredity, stress, aging and hormone. Selenarctos thibetanus (bear oil) has been used frequently as an indigenous medicine for moisture, freckle, cold, gray hair and dandruff. In this study, we investigate the effect of bear oil on hair growth in a depilated animal model of C57BL/6 mice. The animals were divided into 4 groups including negative control group (70%EtOH), positive control group (5% MXD), and experimental group (2%, 5% bear oil) and they were topically applied with an amount of 100 μL once a day for 2 weeks. Topical treatment of 5% bear oil for 2 weeks, hair follicles compared to the group to dorsal skin accelerated hair regrowth faster than 2% bear oil group, minoxidil group and 70% EtOH group. Also, hair density was increased The group treated with bear oil markedly increased the depth and size of the hair follicles in compare to the group treated by minoxidil and 70% EtOH. Also, more hair follicles assumed as in anagen were observed. This result explains that bear oil has effect on prolong of anagen phase, so bear oil might be a potential new therapeutic source for the hair growth promotion.
Abstract
The hair cycle is into 3 phases including anagen, catagen and telogen. Hair loss is the result of premature catagen caused by apoptotic signal. The process of apoptosis is controlled through the activation of many factors, such as heredity, stress, aging and hormone. Selenarctos thibetanus (bear oil) has been used frequently as an indigenous medicine for moisture, freckle, cold, gray hair and dandruff. In this study, we investigate the effect of bear oil on hair growth in a depilated animal model of C57BL/6 mice. The animals were divided into 4 groups including negative control group (70%EtOH), positive control group (5% MXD), and experimental group (2%, 5% bear oil) and they were topically applied with an amount of 100 μL once a day for 2 weeks. Topical treatment of 5% bear oil for 2 weeks, hair follicles compared to the group to dorsal skin accelerated hair regrowth faster than 2% bear oil group, minoxidil group and 70% EtOH group. Also, hair density was increased The group treated with bear oil markedly increased the depth and size of the hair follicles in compare to the group treated by minoxidil and 70% EtOH. Also, more hair follicles assumed as in anagen were observed. This result explains that bear oil has effect on prolong of anagen phase, so bear oil might be a potential new therapeutic source for the hair growth promotion.
참고문헌 (17)
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