C57BL/6 마우스에서 하수오 열수추출물의 육모촉진 효과
The Hair Growth Effect of Polygoni mulitiflori Radix Water Extracts in C57BL/6 Mice
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초록
This study was carried out to investigate the effect of Polygoni mulitiflori Radix water extracts (PMWE) on hair growth and hair follicle development in C57BL/6 mice. Six weeks old female mice were divided into 4 groups including normal group (saline, N), vehicle control group (jojoba oil+100% ethanol+saline, VC), positive control group (3% minoxidil, PC), and experimental group (PMWE, E), and they were topically applied with an amount of 0.2 mL experimental compounds once a day, 6 days a week for 4 weeks. Hair regrowth was evaluated by the gross examination. Topical treatment of PMWE and 3% minoxidil to dorsal skin accelerated hair regrowth faster than N and VC groups. E and PC groups promoted development and elongation of hair follicles compared with N and VC groups. In week 4, absolute weight of heart and spleen were significantly heavy in PC group compared with N, VC and E groups. Relative weight of spleen was significantly heavy in PC group compared with N and VC groups. Relative weight of right kidney was significantly light in PC group compared with N, VC and E groups. Whereas absolute and relative weight of thymus were significantly light in E group compared with N group (p<0.05). In week 4, there was significantly high value of RBC count in PC group compared with N and VC groups, and significantly low value of platelet count in PC group compared with N group (p<0.05). These results indicate that PMEW effectively stimulated hair growth with development of hair follicle in an animal model and that it showed more safer than minoxidil.
Abstract
This study was carried out to investigate the effect of Polygoni mulitiflori Radix water extracts (PMWE) on hair growth and hair follicle development in C57BL/6 mice. Six weeks old female mice were divided into 4 groups including normal group (saline, N), vehicle control group (jojoba oil+100% ethanol+saline, VC), positive control group (3% minoxidil, PC), and experimental group (PMWE, E), and they were topically applied with an amount of 0.2 mL experimental compounds once a day, 6 days a week for 4 weeks. Hair regrowth was evaluated by the gross examination. Topical treatment of PMWE and 3% minoxidil to dorsal skin accelerated hair regrowth faster than N and VC groups. E and PC groups promoted development and elongation of hair follicles compared with N and VC groups. In week 4, absolute weight of heart and spleen were significantly heavy in PC group compared with N, VC and E groups. Relative weight of spleen was significantly heavy in PC group compared with N and VC groups. Relative weight of right kidney was significantly light in PC group compared with N, VC and E groups. Whereas absolute and relative weight of thymus were significantly light in E group compared with N group (p<0.05). In week 4, there was significantly high value of RBC count in PC group compared with N and VC groups, and significantly low value of platelet count in PC group compared with N group (p<0.05). These results indicate that PMEW effectively stimulated hair growth with development of hair follicle in an animal model and that it showed more safer than minoxidil.
참고문헌 (13)
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